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The map label for this gene is atpA

Identifier: 120609073

GI number: 120609073

Start: 395023

End: 396582

Strand: Direct

Name: atpA

Synonym: Aave_0370

Alternate gene names: 120609073

Gene position: 395023-396582 (Clockwise)

Preceding gene: 120609072

Following gene: 120609074

Centisome position: 7.38

GC content: 65.38

Gene sequence:

>1560_bases
ATGCAACTCAATCCCGCAGAGATTTCTGAACTGATCAAGAGCCGCATCGAAGGTCTGGCAGCCAGCAGCGACATCCGCAA
CCAGGGCACCGTGGTGTCCGTGACCGACGGCATCGTGCGCATCCATGGCCTGTCGGAAGTGATGCAGGGCGAAATGCTCG
AATTCCCGGCCACCAAGGACGGCCAGCCTTCCTACGGCCTCGCACTGAACCTCGAGCGCGACTCCGTCGGCGCCGTGATT
CTGGGCGAGTACGAGCACATCTCCGAAGGCGACACCGTGAAGTGCACGGGCCGCATCCTGGAAGTGCCCGTGGGCCCCGA
ACTGGTCGGCCGCGTGGTGAACGCCCTGGGCCAGCCCATCGACGGCAAGGGCCCGATCAACGCCAAGCTGACGGACGTGA
TCGAGAAGGTCGCTCCCGGCGTGATCGCGCGCCAGTCCGTGGACCAGCCGCTGCAGACCGGCATCAAGTCCATCGATGCG
ATGGTGCCCGTGGGCCGTGGCCAGCGCGAGCTGATCATCGGCGACCGCCAGACCGGCAAGACGGCCGTGGCCATCGACGC
CATCATCGCCCAGAAGGGCCAGGGCGTGACGTGTATCTACGTCGCGATCGGCCAGAAGGCTTCGTCGATCAAGAACGTGG
TGCGCGCCCTGGAACAGGCCGGCGCCATGGAATACACGATCGTGGTGGCGGCATCCGCTTCCGAATCGGCTGCCATGCAG
TACGTGTCGGCCTACTCCGGCTGCACGATGGGCGAGTACTTCCGCGACCGCGGCGAAGACGCGCTGATCGTCTATGACGA
CCTGTCCAAGCAGGCCGTGGCCTACCGCCAGGTCTCGCTGCTGCTGCGCCGCCCGCCGGGCCGCGAAGCCTACCCCGGCG
ACGTGTTCTATCTCCACAGCCGCCTGCTGGAGCGCGCAGCCCGCGTGAACGCCGACTACGTCGAAGCCTTCACCAAGGGT
GAAGTCAAGGGCAAGACCGGTTCGCTGACGGCCCTGCCGATCATCGAGACGCAGGCCGGCGACGTGTCCGCCTTCGTCCC
GACGAACGTGATCTCGATCACGGACGGCCAGATCTTCCTGGAAACCAGCCTGTTCAACGCCGGTATCCGTCCCGCCATCA
ACGCCGGTATCTCGGTGTCCCGCGTGGGCGGTGCCGCGCAGACCAAGCTGGTGAAGGGCCTGTCCGGCGGTATCCGTACC
GACCTGGCGCAGTACCGTGAGCTGGCTGCGTTCGCGCAGTTCGCTTCCGACCTGGACGAAGCCACCCGCAAGCAGCTCGA
CCGCGGTGCCCGCGTGACCGAACTGCTCAAGCAGCCCCAGTACACCCCGCTGCCCATCTCGCTGATGGGTGCGACGCTGT
TCGCGGTGAACAAGGGCTTCATGGACGACGTGGACGTGAAGAAGGTGCTCGCCTTCGAATCCGGCCTGCACCAGTTCCTC
AAGACCAGCCACGGCGCCCTGCTGGAGCGCCTGGAGAAGAACCGTGCCTTCGACAAGGAAGGCAAGGACGAGGCCGAACT
GACGCAAGCCATCACGGCCTTCAAGAAGTCGTTCGCCTAA

Upstream 100 bases:

>100_bases
GCTCGACACCTCCGTCAAGGCCCGTCTGGAACAAATGAAAGCGGCCCTCGTCGCTTAAGCGCCCGAGGTTTCGGCTAACC
CAAGAAAGAAGGAAAGAGTC

Downstream 100 bases:

>100_bases
ACCGGACGAGGACCCATCATGGCAGCAGGCAAGGAAATACGCGGCAAGATCAAATCGGTGGAGAACACCAAGAAGATCAC
CAAGGCCATGGAAATGGTGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRIHGLSEVMQGEMLEFPATKDGQPSYGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELVGRVVNALGQPIDGKGPINAKLTDVIEKVAPGVIARQSVDQPLQTGIKSIDA
MVPVGRGQRELIIGDRQTGKTAVAIDAIIAQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYTPLPISLMGATLFAVNKGFMDDVDVKKVLAFESGLHQFL
KTSHGALLERLEKNRAFDKEGKDEAELTQAITAFKKSFA

Sequences:

>Translated_519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRIHGLSEVMQGEMLEFPATKDGQPSYGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELVGRVVNALGQPIDGKGPINAKLTDVIEKVAPGVIARQSVDQPLQTGIKSIDA
MVPVGRGQRELIIGDRQTGKTAVAIDAIIAQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYTPLPISLMGATLFAVNKGFMDDVDVKKVLAFESGLHQFL
KTSHGALLERLEKNRAFDKEGKDEAELTQAITAFKKSFA
>Mature_519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRIHGLSEVMQGEMLEFPATKDGQPSYGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELVGRVVNALGQPIDGKGPINAKLTDVIEKVAPGVIARQSVDQPLQTGIKSIDA
MVPVGRGQRELIIGDRQTGKTAVAIDAIIAQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYTPLPISLMGATLFAVNKGFMDDVDVKKVLAFESGLHQFL
KTSHGALLERLEKNRAFDKEGKDEAELTQAITAFKKSFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=521, Percent_Identity=56.0460652591171, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI4757810, Length=521, Percent_Identity=56.0460652591171, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI32189394, Length=386, Percent_Identity=24.8704663212435, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI19913428, Length=312, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19913426, Length=318, Percent_Identity=27.3584905660377, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19913424, Length=333, Percent_Identity=26.7267267267267, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790172, Length=517, Percent_Identity=68.2785299806576, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=375, Percent_Identity=25.8666666666667, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788251, Length=281, Percent_Identity=28.4697508896797, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71988063, Length=521, Percent_Identity=53.742802303263, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71988080, Length=521, Percent_Identity=53.742802303263, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71988074, Length=521, Percent_Identity=49.9040307101727, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17510931, Length=380, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=373, Percent_Identity=26.0053619302949, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=383, Percent_Identity=24.5430809399478, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17565854, Length=254, Percent_Identity=28.740157480315, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=56, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=522, Percent_Identity=52.4904214559387, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322581, Length=430, Percent_Identity=26.046511627907, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=309, Percent_Identity=27.831715210356, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24658560, Length=521, Percent_Identity=55.8541266794626, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.2131147540984, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.2131147540984, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.2131147540984, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24638766, Length=386, Percent_Identity=24.6113989637306, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574560, Length=324, Percent_Identity=26.5432098765432, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583992, Length=255, Percent_Identity=28.2352941176471, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129479, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_ACIAC (A1TJ39)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968751.1
- ProteinModelPortal:   A1TJ39
- SMR:   A1TJ39
- STRING:   A1TJ39
- GeneID:   4665839
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0370
- NMPDR:   fig|397945.5.peg.333
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   A1TJ39
- ProtClustDB:   PRK09281
- BioCyc:   AAVE397945:AAVE_0370-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55601; Mature: 55601

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRIHGLSEVMQGEMLEFPATKD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCHHHHHCCCCEECCCCCC
GQPSYGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELVGRVVNALGQPI
CCCCCCEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKLTDVIEKVAPGVIARQSVDQPLQTGIKSIDAMVPVGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIIAQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETSLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRTDLAQYRELAAFAQFASDLDE
EEEHHCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQPQYTPLPISLMGATLFAVNKGFMDDVDVKKVLAFESGLHQFL
HHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KTSHGALLERLEKNRAFDKEGKDEAELTQAITAFKKSFA
HCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRIHGLSEVMQGEMLEFPATKD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCHHHHHCCCCEECCCCCC
GQPSYGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELVGRVVNALGQPI
CCCCCCEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKLTDVIEKVAPGVIARQSVDQPLQTGIKSIDAMVPVGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIIAQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEAFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETSLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRTDLAQYRELAAFAQFASDLDE
EEEHHCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQPQYTPLPISLMGATLFAVNKGFMDDVDVKKVLAFESGLHQFL
HHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KTSHGALLERLEKNRAFDKEGKDEAELTQAITAFKKSFA
HCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA