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The map label for this gene is atpB

Identifier: 120609069

GI number: 120609069

Start: 392736

End: 393614

Strand: Direct

Name: atpB

Synonym: Aave_0366

Alternate gene names: 120609069

Gene position: 392736-393614 (Clockwise)

Preceding gene: 120609068

Following gene: 120609070

Centisome position: 7.34

GC content: 62.68

Gene sequence:

>879_bases
ATGGCCGCAGAAGCGCATGCCCCGACTGCCAGTGAATACATCGTTCACCACTTGCAGCATCTTCAGAACATCAAGCAGAA
GTCCATCGTCGATTTCTCCGTGGTGAACATCGACTCCGTCGTGGTCGGCCTGGTGCTCGGCGCGATCGCGCTGTTCGCCT
TCTGGCTGTGCGCGCGCAAGGCCACGTCCGGCGTGCCCGGCCGCTTCCAGGCCGCGGTCGAGATCCTCGTCGAGATGGTG
GACAACCAGGCCAAGGCCAACATCCACAATGCCGAGAGCCGCAAGTTCATCGCCCCGCTGGCGCTCACCGTGTTCGTGTG
GATCTTCCTCATGAACGCGATGGACATGCTGCCCGTGGACCTGCTGCCCGCCATCTGGGCGCAGATCTACGGTGCCGCCG
GCCACGATCCGCACCACGCCTACCTGCGCGTCGTGCCCACGGCCGACCTCTCCACCACGCTGGGCCTGTCCACGGCCGTG
CTGGTCCTCTGCCTGTACTACAGCGTGAAGATCAAGGGCCTGGGCGGCTGGGCGCACGAACTCGTGACCGCTCCGTTCGG
CACGAGCAAGAATCCCGTCTTCGCCCTGATCCTGGGCGTGGTCAACCTGCTGATGCAGATCATCGAATACGTTGCCAAGA
CCGTGTCGCATGGCATGCGGCTGTTCGGCAACATGTACGCTGGTGAGTTGGTGTTCATGCTGATCGCCCTGATGGGCGGC
GCGGCAGCCATGTCGCTTTCCGGTGTGTTGCTCCCCGTGGGGCACATCATTGCGGGCTCTATCTGGGCGATCTTCCACAT
CCTGGTGATCACCCTGCAGGCCTTCATTTTCATGATGCTGGCGCTGATCTACCTCGGCCAGGCGCATGAAGCTCACTGA

Upstream 100 bases:

>100_bases
TCTGCTCGCCGGCATGGTGGTGACGATGAAAACGTACTGGATCGCGCTCATGGCGCGGCCCGGTGTCCGCAAACCGATTG
ATTGAGAGAAGAGTTGTCCG

Downstream 100 bases:

>100_bases
GCCTTCCCTTTCCTTCCTTCTCAACCTTTCTTTCTTTTCATCCTAGGAGTCATCATGGAAAACATTCTCGGTCTCGTCGC
TCTGGCTTGTGGTCTGATCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAAEAHAPTASEYIVHHLQHLQNIKQKSIVDFSVVNIDSVVVGLVLGAIALFAFWLCARKATSGVPGRFQAAVEILVEMV
DNQAKANIHNAESRKFIAPLALTVFVWIFLMNAMDMLPVDLLPAIWAQIYGAAGHDPHHAYLRVVPTADLSTTLGLSTAV
LVLCLYYSVKIKGLGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGG
AAAMSLSGVLLPVGHIIAGSIWAIFHILVITLQAFIFMMLALIYLGQAHEAH

Sequences:

>Translated_292_residues
MAAEAHAPTASEYIVHHLQHLQNIKQKSIVDFSVVNIDSVVVGLVLGAIALFAFWLCARKATSGVPGRFQAAVEILVEMV
DNQAKANIHNAESRKFIAPLALTVFVWIFLMNAMDMLPVDLLPAIWAQIYGAAGHDPHHAYLRVVPTADLSTTLGLSTAV
LVLCLYYSVKIKGLGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGG
AAAMSLSGVLLPVGHIIAGSIWAIFHILVITLQAFIFMMLALIYLGQAHEAH
>Mature_291_residues
AAEAHAPTASEYIVHHLQHLQNIKQKSIVDFSVVNIDSVVVGLVLGAIALFAFWLCARKATSGVPGRFQAAVEILVEMVD
NQAKANIHNAESRKFIAPLALTVFVWIFLMNAMDMLPVDLLPAIWAQIYGAAGHDPHHAYLRVVPTADLSTTLGLSTAVL
VLCLYYSVKIKGLGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGA
AAMSLSGVLLPVGHIIAGSIWAIFHILVITLQAFIFMMLALIYLGQAHEAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=300, Percent_Identity=45.6666666666667, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ACIAC (A1TJ35)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968747.1
- ProteinModelPortal:   A1TJ35
- SMR:   A1TJ35
- STRING:   A1TJ35
- GeneID:   4665350
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0366
- NMPDR:   fig|397945.5.peg.329
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   AGELVFM
- PhylomeDB:   A1TJ35
- ProtClustDB:   PRK05815
- BioCyc:   AAVE397945:AAVE_0366-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 31563; Mature: 31432

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10f0dd44)-; HASH(0x10e2d92c)-; HASH(0x110ff818)-; HASH(0xff303a4)-; HASH(0x1115084c)-; HASH(0x10f45dc4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
AAEAHAPTASEYIVHHLQHLQNIKQKSIVDFSVVNIDSVVVGLVLGAIALFAFWLCARK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSGVPGRFQAAVEILVEMVDNQAKANIHNAESRKFIAPLALTVFVWIFLMNAMDMLPVD
HCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHH
LLPAIWAQIYGAAGHDPHHAYLRVVPTADLSTTLGLSTAVLVLCLYYSVKIKGLGGWAHE
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHH
LVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAAMSLSGVLLPVGHIIAGSIWAIFHILVITLQAFIFMMLALIYLGQAHEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA