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The map label for this gene is alr

Identifier: 120608956

GI number: 120608956

Start: 282246

End: 283355

Strand: Direct

Name: alr

Synonym: Aave_0253

Alternate gene names: 120608956

Gene position: 282246-283355 (Clockwise)

Preceding gene: 120608952

Following gene: 120608957

Centisome position: 5.27

GC content: 71.71

Gene sequence:

>1110_bases
ATGCCGCGCCCCATACAAGCCACCATCCACACTGCTGCACTGCAGCAAAACCTGGCGCGTGCCCGTGCCGCTGCGCCCGA
CGCCCGCGTATGGGCCGTGGTCAAGGCCAACGCCTACGGCCACGGCATCGAGCGCGCCTTCGAGGGGCTGCGCGGCGCGG
ACGGCTTCGCGCTGCTGGATTTGGGCGAGGCAGAGCGGGTGCGCCAGCTGGGATGGCGGGGGCCCATCCTGCTGCTGGAA
GGGGTGTTCGAGCCGCGAGACCTCGAGCTGTGCTCGCGCCTGTCGCTCTGGCACGCGGTGCACTGCGACGAGCAGATCGA
CTGGCTTTCCGCGCACAAGACGCATGCGCCGCACCGGGTTTTCCTCAAGATGAATTCGGGAATGAACCGCCTGGGCTTCC
CTCCCGCGCGCTACCGGGCGGCCTGGGCGCGCCTGAATGCACTGCCGCAGGTGGACGAGATCTCCTTCATGACCCACTTC
AGCGACGCCGACGGGCCGCGGGGCATCGCCCACCAGATCGATGCCTTCTGCACTGCCACGCAGGACTTGCCGGGCGAGCG
CACGGTCAGCAACAGCGCGGCCACCCTGCGGCATGCCGGCGGCGATGCGCGGGTGCGCGGCGACTGGGTGCGCGCGGGCA
TCGTGCTCTACGGCAGTGCCGCCGACCACCCCGAGCACACGGCTGCGCACTGGGGCCTCGCACCCACCATGACGCTGTCG
GCGCGCATCATCGGCACCCAGCAGCTGCAGGCCGGGGATACGGTGGGCTACGGCTCGTCCTTCACCGCGGACCGGCCGAT
GACCATCGGCGTGGTGGCCTGCGGCTATGCCGACGGCTACCCGCGCCATGCCCCCACGGGCACGCCGGTGCTGGTGAACG
GCGTGCGCACCCGCACCGTGGGCCGGGTGAGCATGGACATGATCACGGTGGACCTCACGCCGCTGCACGAGGCCGGCGTG
GAGGCGGGCGTGGGCAGCGAGGCCACCCTGTGGGGCCGCGCGTCGTGCGGGGCCGTGCTGTGCATCGACGAGGTGGCGCA
GGCGGCGGGCACGGTGGGCTACGAGCTGATGTGCGCCCTGGCCCCGCGCGTGCCGGTGGTGGTGGACTGA

Upstream 100 bases:

>100_bases
TTAAATCTCGGAACCGGCTGCAAGTGACTGGCGGTTATATCACGCGCCCCGTGCGCTCCAATGCCAGAATTCCCTCCTTT
TCGCCCGCCGTTCCGTCCCC

Downstream 100 bases:

>100_bases
CCGGTGCGCGGCAAGGCCCGGCCCGGACAGCGCTCCGGCGGCTCGAACTGGCGCCGCGTGCGCACGCCCGGGCGCACGCT
GGAGGCCTCGCTGCTGAACC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MPRPIQATIHTAALQQNLARARAAAPDARVWAVVKANAYGHGIERAFEGLRGADGFALLDLGEAERVRQLGWRGPILLLE
GVFEPRDLELCSRLSLWHAVHCDEQIDWLSAHKTHAPHRVFLKMNSGMNRLGFPPARYRAAWARLNALPQVDEISFMTHF
SDADGPRGIAHQIDAFCTATQDLPGERTVSNSAATLRHAGGDARVRGDWVRAGIVLYGSAADHPEHTAAHWGLAPTMTLS
ARIIGTQQLQAGDTVGYGSSFTADRPMTIGVVACGYADGYPRHAPTGTPVLVNGVRTRTVGRVSMDMITVDLTPLHEAGV
EAGVGSEATLWGRASCGAVLCIDEVAQAAGTVGYELMCALAPRVPVVVD

Sequences:

>Translated_369_residues
MPRPIQATIHTAALQQNLARARAAAPDARVWAVVKANAYGHGIERAFEGLRGADGFALLDLGEAERVRQLGWRGPILLLE
GVFEPRDLELCSRLSLWHAVHCDEQIDWLSAHKTHAPHRVFLKMNSGMNRLGFPPARYRAAWARLNALPQVDEISFMTHF
SDADGPRGIAHQIDAFCTATQDLPGERTVSNSAATLRHAGGDARVRGDWVRAGIVLYGSAADHPEHTAAHWGLAPTMTLS
ARIIGTQQLQAGDTVGYGSSFTADRPMTIGVVACGYADGYPRHAPTGTPVLVNGVRTRTVGRVSMDMITVDLTPLHEAGV
EAGVGSEATLWGRASCGAVLCIDEVAQAAGTVGYELMCALAPRVPVVVD
>Mature_368_residues
PRPIQATIHTAALQQNLARARAAAPDARVWAVVKANAYGHGIERAFEGLRGADGFALLDLGEAERVRQLGWRGPILLLEG
VFEPRDLELCSRLSLWHAVHCDEQIDWLSAHKTHAPHRVFLKMNSGMNRLGFPPARYRAAWARLNALPQVDEISFMTHFS
DADGPRGIAHQIDAFCTATQDLPGERTVSNSAATLRHAGGDARVRGDWVRAGIVLYGSAADHPEHTAAHWGLAPTMTLSA
RIIGTQQLQAGDTVGYGSSFTADRPMTIGVVACGYADGYPRHAPTGTPVLVNGVRTRTVGRVSMDMITVDLTPLHEAGVE
AGVGSEATLWGRASCGAVLCIDEVAQAAGTVGYELMCALAPRVPVVVD

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=367, Percent_Identity=53.133514986376, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1790487, Length=360, Percent_Identity=39.1666666666667, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_ACIAC (A1TIS2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968634.1
- ProteinModelPortal:   A1TIS2
- SMR:   A1TIS2
- STRING:   A1TIS2
- GeneID:   4667043
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0253
- NMPDR:   fig|397945.5.peg.221
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   SVELWGD
- PhylomeDB:   A1TIS2
- ProtClustDB:   CLSK951002
- BioCyc:   AAVE397945:AAVE_0253-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39526; Mature: 39395

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPIQATIHTAALQQNLARARAAAPDARVWAVVKANAYGHGIERAFEGLRGADGFALLD
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEE
LGEAERVRQLGWRGPILLLEGVFEPRDLELCSRLSLWHAVHCDEQIDWLSAHKTHAPHRV
CCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
FLKMNSGMNRLGFPPARYRAAWARLNALPQVDEISFMTHFSDADGPRGIAHQIDAFCTAT
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHC
QDLPGERTVSNSAATLRHAGGDARVRGDWVRAGIVLYGSAADHPEHTAAHWGLAPTMTLS
CCCCCCCCCCCCHHHHEECCCCCEEECCEEEEEEEEECCCCCCCCCHHHHCCCCCCEEEE
ARIIGTQQLQAGDTVGYGSSFTADRPMTIGVVACGYADGYPRHAPTGTPVLVNGVRTRTV
EEEEECCHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEE
GRVSMDMITVDLTPLHEAGVEAGVGSEATLWGRASCGAVLCIDEVAQAAGTVGYELMCAL
CEEEEEEEEEECCCCHHHCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHCCCCHHHHHHH
APRVPVVVD
CCCCCEEEC
>Mature Secondary Structure 
PRPIQATIHTAALQQNLARARAAAPDARVWAVVKANAYGHGIERAFEGLRGADGFALLD
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEE
LGEAERVRQLGWRGPILLLEGVFEPRDLELCSRLSLWHAVHCDEQIDWLSAHKTHAPHRV
CCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
FLKMNSGMNRLGFPPARYRAAWARLNALPQVDEISFMTHFSDADGPRGIAHQIDAFCTAT
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHC
QDLPGERTVSNSAATLRHAGGDARVRGDWVRAGIVLYGSAADHPEHTAAHWGLAPTMTLS
CCCCCCCCCCCCHHHHEECCCCCEEECCEEEEEEEEECCCCCCCCCHHHHCCCCCCEEEE
ARIIGTQQLQAGDTVGYGSSFTADRPMTIGVVACGYADGYPRHAPTGTPVLVNGVRTRTV
EEEEECCHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEE
GRVSMDMITVDLTPLHEAGVEAGVGSEATLWGRASCGAVLCIDEVAQAAGTVGYELMCAL
CEEEEEEEEEECCCCHHHCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHCCCCHHHHHHH
APRVPVVVD
CCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA