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The map label for this gene is folM [H]

Identifier: 120597555

GI number: 120597555

Start: 803192

End: 803911

Strand: Direct

Name: folM [H]

Synonym: Sputw3181_0724

Alternate gene names: 120597555

Gene position: 803192-803911 (Clockwise)

Preceding gene: 120597553

Following gene: 120597558

Centisome position: 17.06

GC content: 46.81

Gene sequence:

>720_bases
ATGACATCTCCCATCATCATCACAGGCGTGGGTAAACGCATAGGTTACGCCTTAGCCAAACATCTTCTTGCCCAAGGTCA
TAGTGTGATTGGCACCTATCGTAGCCATTATCCGAGTATTGATAAGCTGCGGGTTTTGGGCGCGACTATAATCCAATGTG
ACTTTTACGACAATGTTCAGGTACAAGGCTTAATTGATCAATTGAGCCAGTATCCAAAGATCCGCGCCATTATCCATAAC
GCCTCGGATTGGTTGGCGGATAGCAGTCAAACCTATACTGCCAGCGAAGTGATACAGCGGATGATGCAGGTGCACGTAAG
CGTACCTTATCAATTGAATTTGGCGTTAGCATCGCAGTTGCAAGCAGGTGCAGAAGAGGAGATTGGTGCCAGCGATATCA
TCCATATCACCGACTATGTGGCCGAAAAGGGCAGTGCTAAACATATCGCTTATGCCGGCAGTAAAGCGGCGCTACATAAT
TTAACTTTGTCCTTTGCGGCTAAATTCGCCCCCGAAGTGAAAGTCAATTCGATTGCGCCAGCGATGATCCTATTTAATCA
AGGCGATGATGAAGCCTATCAGCAAAAAACCTTAGCTAAAGCACTACTGCCAAAAGAGGCGGGGAATGAAGAGATTATCG
ATTTAGTGGAATATCTGCTAAATAGCCGCTATGTCACGGGGCGCAGCCATCATGTCGATGGTGGTCGGCATTTAAGGTAA

Upstream 100 bases:

>100_bases
TGAGTGCAGTAACATCTTGGTTATTCATCAGTTTAACTTGATTGCTGATTTTTAAGTGAACAAGGTAAAGCCTGACAAAT
AACGACTCAAAAGGATAGGT

Downstream 100 bases:

>100_bases
AAAAGAATCTAGATTTTAGGTCCTAGGCCCTAGAATCTAATTACCTAGCACTTTCTTTTTTAAAACGTCAGCACACGACT
TGGGGTGATGATAATAGGTA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTSPIIITGVGKRIGYALAKHLLAQGHSVIGTYRSHYPSIDKLRVLGATIIQCDFYDNVQVQGLIDQLSQYPKIRAIIHN
ASDWLADSSQTYTASEVIQRMMQVHVSVPYQLNLALASQLQAGAEEEIGASDIIHITDYVAEKGSAKHIAYAGSKAALHN
LTLSFAAKFAPEVKVNSIAPAMILFNQGDDEAYQQKTLAKALLPKEAGNEEIIDLVEYLLNSRYVTGRSHHVDGGRHLR

Sequences:

>Translated_239_residues
MTSPIIITGVGKRIGYALAKHLLAQGHSVIGTYRSHYPSIDKLRVLGATIIQCDFYDNVQVQGLIDQLSQYPKIRAIIHN
ASDWLADSSQTYTASEVIQRMMQVHVSVPYQLNLALASQLQAGAEEEIGASDIIHITDYVAEKGSAKHIAYAGSKAALHN
LTLSFAAKFAPEVKVNSIAPAMILFNQGDDEAYQQKTLAKALLPKEAGNEEIIDLVEYLLNSRYVTGRSHHVDGGRHLR
>Mature_238_residues
TSPIIITGVGKRIGYALAKHLLAQGHSVIGTYRSHYPSIDKLRVLGATIIQCDFYDNVQVQGLIDQLSQYPKIRAIIHNA
SDWLADSSQTYTASEVIQRMMQVHVSVPYQLNLALASQLQAGAEEEIGASDIIHITDYVAEKGSAKHIAYAGSKAALHNL
TLSFAAKFAPEVKVNSIAPAMILFNQGDDEAYQQKTLAKALLPKEAGNEEIIDLVEYLLNSRYVTGRSHHVDGGRHLR

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=237, Percent_Identity=55.2742616033755, Blast_Score=245, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24643142, Length=238, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=25.4980079681275, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 26208; Mature: 26077

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIIITGVGKRIGYALAKHLLAQGHSVIGTYRSHYPSIDKLRVLGATIIQCDFYDNVQ
CCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEEEEEECCCCCH
VQGLIDQLSQYPKIRAIIHNASDWLADSSQTYTASEVIQRMMQVHVSVPYQLNLALASQL
HHHHHHHHHHCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHH
QAGAEEEIGASDIIHITDYVAEKGSAKHIAYAGSKAALHNLTLSFAAKFAPEVKVNSIAP
HCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCC
AMILFNQGDDEAYQQKTLAKALLPKEAGNEEIIDLVEYLLNSRYVTGRSHHVDGGRHLR
EEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TSPIIITGVGKRIGYALAKHLLAQGHSVIGTYRSHYPSIDKLRVLGATIIQCDFYDNVQ
CCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEEEEEECCCCCH
VQGLIDQLSQYPKIRAIIHNASDWLADSSQTYTASEVIQRMMQVHVSVPYQLNLALASQL
HHHHHHHHHHCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHH
QAGAEEEIGASDIIHITDYVAEKGSAKHIAYAGSKAALHNLTLSFAAKFAPEVKVNSIAP
HCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCC
AMILFNQGDDEAYQQKTLAKALLPKEAGNEEIIDLVEYLLNSRYVTGRSHHVDGGRHLR
EEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA