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The map label for this gene is ywrD [H]

Identifier: 120597548

GI number: 120597548

Start: 795999

End: 797711

Strand: Direct

Name: ywrD [H]

Synonym: Sputw3181_0717

Alternate gene names: 120597548

Gene position: 795999-797711 (Clockwise)

Preceding gene: 120597547

Following gene: 120597549

Centisome position: 16.91

GC content: 45.42

Gene sequence:

>1713_bases
ATGCTAAAAAAAATAAATTTAATTTGTACCCTCGTTATTGTAACAACTGCGATATTGTCTTCAGGAGTGATGGCCATGGA
TAGGATCACAGGTAAAGCTTTTGCAACTCGTTCTGAAGTGTATGCAACCCAAGGGATGGCGGCGACAAGCCAACCCTTAG
CGACACAGGTTGCGATCGATATTCTTAAACAAGGCGGTAGTGCTGTTGATGCGGCTATTGCCGCCAATGCGATGCTAGGG
TTAGTTGAACCGACAGGTTCCGGTGTAGGTGGTGATTTATTTGCAATTGTGTGGAGTGCGAAAGATAAACGTCTCTATGG
TCTTAATGCCTCTGGTCGCAGCCCCAAATCCTTAACGCTAGAGAAGCTAAAATCCCTCGGATTAGATTACTTGCCTCCTT
TGGGGCCGCTACCCGTATCCGTTCCCGGCGCGGTGGATGGATGGTTCGAACTGCACGATAAGTTCGGCAAGTTACCAATG
GCCGATAACTTAGCGCCAGCGATTCGTTATGCCCGCGAAGGTTTCCCTGTCTCCGAGTTGATTGCCTATTACCTTGAGGG
CAGCGGTAAAAAGCTTGCTCAATTCCCCGGTTTTAAAGAAACCTATATGCCAAATGGCAAAATGCCAGCCGTAGGGGAAA
TCTTTAAAAATCCTGCGCTTGCTAATACTTATGAAAAAATTGCCAAGGATGGGCGCGATGCTTTTTATAAAGGGGATATC
GCCAAAAGTATAGATAAGTATATGAAATCTCAAGGTGGCTATTTAAGTTATGATGATTTAGCGAGTCATACGAGTGAATG
GGTTGATCCAGTTTCGGTCAATTACCGAGGTTACGATGTGTGGGAATTGCCGCCCAATGGACAGGGTATTGCTGCGCTGC
AAATCCTTAAAACGATGGAGCCCTTTAATGTTGCTGCTATGGGCTTTAATAGTCCTGAATACGTACATTTATTTGTTGAG
GCTAAAAAACTCGCCTTTGCCGACAGGGCGAAGTTTTATGCAGATATGGCTTTTAACAAAGTCCCCGTTACAGAGCTTAT
CTCACAGAAATATAACTATGATCGCGCTAAGTTAATCAATCCTAATAAAGCCGCTAAAAGCGTTGATGCTGGAAATCCAG
CATTACAACATGGTGATACGGTTTATCTAACTACCGCCGACAAAGATGGCAATATGGTGTCACTCATTCAGAGTAATTAC
CGTGGTATGGGCTCTGGGATGACACCACCAGATCTTGGTTTTGTATTGCAGGATCGTGGGCAAATGTTTGATTTAACAGA
GGGGCGTTTTAATTCATACGCCCCTGGTAAGAGGCCATTCCAAACCATTATTCCCGCTTTTGTGACTAAAGATGGGAAGC
CTTGGCTGAGTTTTGGTGTGATGGGCGGCGCAACCCAGCCACAAATGCATGCTCAAATATTAGTCAATCTCATTGATTTT
AAAATGAACTTGCAAGAAGCGGGCGATGCTCCCAGAATTTTACATTCTGGCTCCACTGAGCCAACGGGTGAAGTCATGCA
TGATGGTGGTTATGTCAGTCTGGAATCAGGTTTCCCGGTAGAAACCCGCCGTGAGTTAATTAAGAAAGGCCATGTGTTGC
GTGATAGTCTTGGTGATTTTGGCGGCTATCAAGCCATTGGATTTAATGCCGAAACGGGTGTATATCGTGCGGCATCTGAG
AGTCGCAAGGATGGTCACGCCGCAGGCTATTAA

Upstream 100 bases:

>100_bases
TAAGACATTTTTGCTTACGTTTAACTTGGGTCTACGCAGTATTGGATGATGATATTTTCAACCATCCTTGTTACTTTAAA
CCTCCGGTTTCGGAGGATTT

Downstream 100 bases:

>100_bases
CACTAATATAAATGCTAAGGTAAACTCAACACTGAGTGAACCTGACTTCATTGATTCGATTAAACTGATTGGCGAGACTT
TAATGGTCTCGTCAATTTTT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLKKINLICTLVIVTTAILSSGVMAMDRITGKAFATRSEVYATQGMAATSQPLATQVAIDILKQGGSAVDAAIAANAMLG
LVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKSLTLEKLKSLGLDYLPPLGPLPVSVPGAVDGWFELHDKFGKLPM
ADNLAPAIRYAREGFPVSELIAYYLEGSGKKLAQFPGFKETYMPNGKMPAVGEIFKNPALANTYEKIAKDGRDAFYKGDI
AKSIDKYMKSQGGYLSYDDLASHTSEWVDPVSVNYRGYDVWELPPNGQGIAALQILKTMEPFNVAAMGFNSPEYVHLFVE
AKKLAFADRAKFYADMAFNKVPVTELISQKYNYDRAKLINPNKAAKSVDAGNPALQHGDTVYLTTADKDGNMVSLIQSNY
RGMGSGMTPPDLGFVLQDRGQMFDLTEGRFNSYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQILVNLIDF
KMNLQEAGDAPRILHSGSTEPTGEVMHDGGYVSLESGFPVETRRELIKKGHVLRDSLGDFGGYQAIGFNAETGVYRAASE
SRKDGHAAGY

Sequences:

>Translated_570_residues
MLKKINLICTLVIVTTAILSSGVMAMDRITGKAFATRSEVYATQGMAATSQPLATQVAIDILKQGGSAVDAAIAANAMLG
LVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKSLTLEKLKSLGLDYLPPLGPLPVSVPGAVDGWFELHDKFGKLPM
ADNLAPAIRYAREGFPVSELIAYYLEGSGKKLAQFPGFKETYMPNGKMPAVGEIFKNPALANTYEKIAKDGRDAFYKGDI
AKSIDKYMKSQGGYLSYDDLASHTSEWVDPVSVNYRGYDVWELPPNGQGIAALQILKTMEPFNVAAMGFNSPEYVHLFVE
AKKLAFADRAKFYADMAFNKVPVTELISQKYNYDRAKLINPNKAAKSVDAGNPALQHGDTVYLTTADKDGNMVSLIQSNY
RGMGSGMTPPDLGFVLQDRGQMFDLTEGRFNSYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQILVNLIDF
KMNLQEAGDAPRILHSGSTEPTGEVMHDGGYVSLESGFPVETRRELIKKGHVLRDSLGDFGGYQAIGFNAETGVYRAASE
SRKDGHAAGY
>Mature_570_residues
MLKKINLICTLVIVTTAILSSGVMAMDRITGKAFATRSEVYATQGMAATSQPLATQVAIDILKQGGSAVDAAIAANAMLG
LVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKSLTLEKLKSLGLDYLPPLGPLPVSVPGAVDGWFELHDKFGKLPM
ADNLAPAIRYAREGFPVSELIAYYLEGSGKKLAQFPGFKETYMPNGKMPAVGEIFKNPALANTYEKIAKDGRDAFYKGDI
AKSIDKYMKSQGGYLSYDDLASHTSEWVDPVSVNYRGYDVWELPPNGQGIAALQILKTMEPFNVAAMGFNSPEYVHLFVE
AKKLAFADRAKFYADMAFNKVPVTELISQKYNYDRAKLINPNKAAKSVDAGNPALQHGDTVYLTTADKDGNMVSLIQSNY
RGMGSGMTPPDLGFVLQDRGQMFDLTEGRFNSYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQILVNLIDF
KMNLQEAGDAPRILHSGSTEPTGEVMHDGGYVSLESGFPVETRRELIKKGHVLRDSLGDFGGYQAIGFNAETGVYRAASE
SRKDGHAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=562, Percent_Identity=28.1138790035587, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915090, Length=562, Percent_Identity=28.1138790035587, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915096, Length=562, Percent_Identity=28.1138790035587, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915094, Length=562, Percent_Identity=28.1138790035587, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI113429324, Length=554, Percent_Identity=25.9927797833935, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI113429326, Length=559, Percent_Identity=26.2969588550984, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI109148539, Length=506, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI153266885, Length=558, Percent_Identity=24.910394265233, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI153266901, Length=559, Percent_Identity=24.865831842576, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI153266907, Length=558, Percent_Identity=23.8351254480287, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI1789856, Length=565, Percent_Identity=31.858407079646, Blast_Score=241, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193208245, Length=516, Percent_Identity=26.7441860465116, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193208247, Length=516, Percent_Identity=26.7441860465116, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17542894, Length=500, Percent_Identity=26.4, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI72000294, Length=559, Percent_Identity=26.1180679785331, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI212646519, Length=559, Percent_Identity=26.1180679785331, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17506189, Length=573, Percent_Identity=25.3054101221641, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077878, Length=552, Percent_Identity=27.8985507246377, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077880, Length=552, Percent_Identity=27.8985507246377, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24642670, Length=552, Percent_Identity=27.8985507246377, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24642666, Length=552, Percent_Identity=27.8985507246377, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45551474, Length=552, Percent_Identity=27.8985507246377, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161077496, Length=554, Percent_Identity=25.9927797833935, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI18859893, Length=461, Percent_Identity=26.2472885032538, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18859741, Length=474, Percent_Identity=24.2616033755274, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61674; Mature: 61674

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKINLICTLVIVTTAILSSGVMAMDRITGKAFATRSEVYATQGMAATSQPLATQVAID
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ILKQGGSAVDAAIAANAMLGLVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKSLTL
HHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHH
EKLKSLGLDYLPPLGPLPVSVPGAVDGWFELHDKFGKLPMADNLAPAIRYAREGFPVSEL
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
IAYYLEGSGKKLAQFPGFKETYMPNGKMPAVGEIFKNPALANTYEKIAKDGRDAFYKGDI
HHHHHCCCCCHHHHCCCCCHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCHHHCCHH
AKSIDKYMKSQGGYLSYDDLASHTSEWVDPVSVNYRGYDVWELPPNGQGIAALQILKTME
HHHHHHHHHCCCCEECHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCC
PFNVAAMGFNSPEYVHLFVEAKKLAFADRAKFYADMAFNKVPVTELISQKYNYDRAKLIN
CCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHEECC
PNKAAKSVDAGNPALQHGDTVYLTTADKDGNMVSLIQSNYRGMGSGMTPPDLGFVLQDRG
CCHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEHEEHHCCCCCCCCCCCCCCCHHCCCCC
QMFDLTEGRFNSYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQILVNLIDF
CEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
KMNLQEAGDAPRILHSGSTEPTGEVMHDGGYVSLESGFPVETRRELIKKGHVLRDSLGDF
HHHHHHCCCCCCEEECCCCCCCCCEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHCCC
GGYQAIGFNAETGVYRAASESRKDGHAAGY
CCEEEEECCCCCCCEECCHHCCCCCCCCCC
>Mature Secondary Structure
MLKKINLICTLVIVTTAILSSGVMAMDRITGKAFATRSEVYATQGMAATSQPLATQVAID
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ILKQGGSAVDAAIAANAMLGLVEPTGSGVGGDLFAIVWSAKDKRLYGLNASGRSPKSLTL
HHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHH
EKLKSLGLDYLPPLGPLPVSVPGAVDGWFELHDKFGKLPMADNLAPAIRYAREGFPVSEL
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
IAYYLEGSGKKLAQFPGFKETYMPNGKMPAVGEIFKNPALANTYEKIAKDGRDAFYKGDI
HHHHHCCCCCHHHHCCCCCHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCHHHCCHH
AKSIDKYMKSQGGYLSYDDLASHTSEWVDPVSVNYRGYDVWELPPNGQGIAALQILKTME
HHHHHHHHHCCCCEECHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCC
PFNVAAMGFNSPEYVHLFVEAKKLAFADRAKFYADMAFNKVPVTELISQKYNYDRAKLIN
CCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHEECC
PNKAAKSVDAGNPALQHGDTVYLTTADKDGNMVSLIQSNYRGMGSGMTPPDLGFVLQDRG
CCHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEHEEHHCCCCCCCCCCCCCCCHHCCCCC
QMFDLTEGRFNSYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGATQPQMHAQILVNLIDF
CEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
KMNLQEAGDAPRILHSGSTEPTGEVMHDGGYVSLESGFPVETRRELIKKGHVLRDSLGDF
HHHHHHCCCCCCEEECCCCCCCCCEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHCCC
GGYQAIGFNAETGVYRAASESRKDGHAAGY
CCEEEEECCCCCCCEECCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]