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The map label for this gene is lysC [H]

Identifier: 119946984

GI number: 119946984

Start: 4172531

End: 4173763

Strand: Reverse

Name: lysC [H]

Synonym: Ping_3379

Alternate gene names: 119946984

Gene position: 4173763-4172531 (Counterclockwise)

Preceding gene: 119946985

Following gene: 119946983

Centisome position: 91.54

GC content: 41.93

Gene sequence:

>1233_bases
ATGGCATTATTAGTTCAAAAATACGGTGGGACCTCTGTAGGTAACATTGAGCGCATAAAAAGCGTGGCTGAAAAAATTAA
AGCAACAAAAGCAGACGGTCACGATGTTGTGGTTGTATTATCCGCCATGTCGGGTGAGACAAATCGTATGATAGCGCTCG
CAAAAGAGATAACAGCAAACCCAAGTCCTCGTGAAATGGATGTGTTGTTAACAACTGGCGAGCAAACGACCATTGCACTT
TTATCAATGGCATTACATAGTTTAGGCCTTGATGCCGTCTCTATGACAGGTGACCAAATCCGTTTAAAGACAGACTCCTG
TCATAGTAAGGCGCGTATTTTAGATGTTGAAACAAAAAATATTAAGGAGCATTTAAAACTTGGACGGGTGGTGGTAGTGG
CAGGTTTTCAAGGCCGCTCGGAAACTAATGAGATTACTACGTTGGGTCGGGGAGGCTCGGATACATCTGCGGTAGCTATT
GCTGCGGCTTTAAAAGCGGACGAATGCCAAATTTATACTGATGTTGACGGTGTTTATACAACGGATCCGCGTGTTGAACC
CAATGCTCGCCGTTTAGATAGGATTACCTTTGAAGAGATGCTTGAAATGGCGAGCTTAGGCGCTAAGGTTTTACAAATTC
GCTCAGTCGAGTTTGCTGGAAAATATAATGTACCACTTCGTGTCCTATCAAGTTTTAAAGATGGTGGCGGCACGCTAATC
TGTTATGAGGAAAATAAAATGGAATCTCCTGTCATCTCCGGTATTGCGTTTAATCGTGATGAAGCTCGTTTAACCTTATC
GGGTGTACCAGATAAACCGACCGTTGCTGCACAAATTTTATCGCCTATTGGTGATGCTAATATCGATGTGGATATGATAG
TACAAAATACGCTGGGTAACGGGAAAACAGATTTTACTTTTACTGTGCATCGTGATGACTATGAGCAAACCAAGGAACTA
TTAGAGAAGGTATGTGTCTTATTACACGCTGATAATGTTCAGGGTAATAAGGAAATAGCAAAAGTTTCAGTTGTGGGCGT
TGGAATGTGGAACCATCCGGGTGTTGCTAAAACCATGTTTGAAACACTGGGGCAAGAAGGTATTAATATGCACCAAATTG
CAACGTCAGAAATAAAAATCTCAGTTTTGGTTGATAGTAAGTATCTGGAACTTGCTGTGCGGGCACTGCATAAAGCATTT
AAACTTGCAGATGACCCGACAGAAGAAAAATAA

Upstream 100 bases:

>100_bases
GCGTTAGCTGATGCACTTGCATTAGTAGCACCCTGGTTAAGTGAGCGTTTGTAATAGGTAGATTTGCTATGTAAATAGCT
TGAAGATATGGGAAATGACG

Downstream 100 bases:

>100_bases
ATTTTGGGATATGGTGCAGTAAAAACACAGGCAAGATAGCCTGTACTGGTCCATACTTGATTTCAATGGATAGATTAATC
CTAACAGGAGCTGGGGCATG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MALLVQKYGGTSVGNIERIKSVAEKIKATKADGHDVVVVLSAMSGETNRMIALAKEITANPSPREMDVLLTTGEQTTIAL
LSMALHSLGLDAVSMTGDQIRLKTDSCHSKARILDVETKNIKEHLKLGRVVVVAGFQGRSETNEITTLGRGGSDTSAVAI
AAALKADECQIYTDVDGVYTTDPRVEPNARRLDRITFEEMLEMASLGAKVLQIRSVEFAGKYNVPLRVLSSFKDGGGTLI
CYEENKMESPVISGIAFNRDEARLTLSGVPDKPTVAAQILSPIGDANIDVDMIVQNTLGNGKTDFTFTVHRDDYEQTKEL
LEKVCVLLHADNVQGNKEIAKVSVVGVGMWNHPGVAKTMFETLGQEGINMHQIATSEIKISVLVDSKYLELAVRALHKAF
KLADDPTEEK

Sequences:

>Translated_410_residues
MALLVQKYGGTSVGNIERIKSVAEKIKATKADGHDVVVVLSAMSGETNRMIALAKEITANPSPREMDVLLTTGEQTTIAL
LSMALHSLGLDAVSMTGDQIRLKTDSCHSKARILDVETKNIKEHLKLGRVVVVAGFQGRSETNEITTLGRGGSDTSAVAI
AAALKADECQIYTDVDGVYTTDPRVEPNARRLDRITFEEMLEMASLGAKVLQIRSVEFAGKYNVPLRVLSSFKDGGGTLI
CYEENKMESPVISGIAFNRDEARLTLSGVPDKPTVAAQILSPIGDANIDVDMIVQNTLGNGKTDFTFTVHRDDYEQTKEL
LEKVCVLLHADNVQGNKEIAKVSVVGVGMWNHPGVAKTMFETLGQEGINMHQIATSEIKISVLVDSKYLELAVRALHKAF
KLADDPTEEK
>Mature_409_residues
ALLVQKYGGTSVGNIERIKSVAEKIKATKADGHDVVVVLSAMSGETNRMIALAKEITANPSPREMDVLLTTGEQTTIALL
SMALHSLGLDAVSMTGDQIRLKTDSCHSKARILDVETKNIKEHLKLGRVVVVAGFQGRSETNEITTLGRGGSDTSAVAIA
AALKADECQIYTDVDGVYTTDPRVEPNARRLDRITFEEMLEMASLGAKVLQIRSVEFAGKYNVPLRVLSSFKDGGGTLIC
YEENKMESPVISGIAFNRDEARLTLSGVPDKPTVAAQILSPIGDANIDVDMIVQNTLGNGKTDFTFTVHRDDYEQTKELL
EKVCVLLHADNVQGNKEIAKVSVVGVGMWNHPGVAKTMFETLGQEGINMHQIATSEIKISVLVDSKYLELAVRALHKAFK
LADDPTEEK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=475, Percent_Identity=28.8421052631579, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790455, Length=274, Percent_Identity=35.4014598540146, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790376, Length=281, Percent_Identity=25.6227758007117, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=422, Percent_Identity=25.8293838862559, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44469; Mature: 44337

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLVQKYGGTSVGNIERIKSVAEKIKATKADGHDVVVVLSAMSGETNRMIALAKEITAN
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEEHHHCCC
PSPREMDVLLTTGEQTTIALLSMALHSLGLDAVSMTGDQIRLKTDSCHSKARILDVETKN
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEEEECHHH
IKEHLKLGRVVVVAGFQGRSETNEITTLGRGGSDTSAVAIAAALKADECQIYTDVDGVYT
HHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHEEEHHCCCCEEEEECCCCEEE
TDPRVEPNARRLDRITFEEMLEMASLGAKVLQIRSVEFAGKYNVPLRVLSSFKDGGGTLI
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEEEEEEECCCCCCHHHHHHHCCCCCCEEE
CYEENKMESPVISGIAFNRDEARLTLSGVPDKPTVAAQILSPIGDANIDVDMIVQNTLGN
EEECCCCCCCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCC
GKTDFTFTVHRDDYEQTKELLEKVCVLLHADNVQGNKEIAKVSVVGVGMWNHPGVAKTMF
CCCEEEEEEECCCHHHHHHHHHHHHHEEECCCCCCCCEEEEEEEEEEECCCCCCHHHHHH
ETLGQEGINMHQIATSEIKISVLVDSKYLELAVRALHKAFKLADDPTEEK
HHHCCCCCCEEEEEECEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ALLVQKYGGTSVGNIERIKSVAEKIKATKADGHDVVVVLSAMSGETNRMIALAKEITAN
EEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEEHHHCCC
PSPREMDVLLTTGEQTTIALLSMALHSLGLDAVSMTGDQIRLKTDSCHSKARILDVETKN
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEEEECHHH
IKEHLKLGRVVVVAGFQGRSETNEITTLGRGGSDTSAVAIAAALKADECQIYTDVDGVYT
HHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHEEEHHCCCCEEEEECCCCEEE
TDPRVEPNARRLDRITFEEMLEMASLGAKVLQIRSVEFAGKYNVPLRVLSSFKDGGGTLI
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEEEEEEECCCCCCHHHHHHHCCCCCCEEE
CYEENKMESPVISGIAFNRDEARLTLSGVPDKPTVAAQILSPIGDANIDVDMIVQNTLGN
EEECCCCCCCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCC
GKTDFTFTVHRDDYEQTKELLEKVCVLLHADNVQGNKEIAKVSVVGVGMWNHPGVAKTMF
CCCEEEEEEECCCHHHHHHHHHHHHHEEECCCCCCCCEEEEEEEEEEECCCCCCHHHHHH
ETLGQEGINMHQIATSEIKISVLVDSKYLELAVRALHKAFKLADDPTEEK
HHHCCCCCCEEEEEECEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]