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The map label for this gene is lspA

Identifier: 119946876

GI number: 119946876

Start: 4034733

End: 4035254

Strand: Reverse

Name: lspA

Synonym: Ping_3270

Alternate gene names: 119946876

Gene position: 4035254-4034733 (Counterclockwise)

Preceding gene: 119946877

Following gene: 119946875

Centisome position: 88.5

GC content: 36.21

Gene sequence:

>522_bases
ATGGCAGAAATAATAGAAAAATCAGGTTTGCGCTGGTTATGGCTCGCCGCAATCATGTTAGCGCTTGACCAAGTAACTAA
GTATTGGACAATACAATCATTAGATTTATATGAATCTTATGAGATTTTTTCATTCTTTAGCTTTACCTACGCAAGAAATT
ACGGTGCAGCGTTTAGCTTTTTAGGTGATGCAGGAGGGTGGCAAAGATATCTGTTTACGGCCATTGCAATCGTCGTTTCA
AGTTATTTAGTTTACTTATTAAAGAAAAATGCTTCGACAGATCGTTGGATTAACTGTGCTTATGCATTGATCTTATCGGG
TGCGCTTGGCAATGTAGTCGATCGTATGATGTTTGGTTATGTCATCGATTTTTTAGATTTTGATTTAGGTTTTTATCGCT
GGCCAACCTTTAATATTGCAGATAGTGCTATTTTTACGGGGGCTGTAATAATGATTTTTGAGTCTTTTTTTGCCAAACAG
GCAAAACCAATTAAACAACCAAAGGGAAATAAAAATGTCTGA

Upstream 100 bases:

>100_bases
CATTATCTAACATAGACCCAAACTATTTGAATCTGCATCTTCGAGCAGTTTGGGTCTAAACGCCTTACTACTTTAAGGCG
TTTTTTAATTGGGATTTAGA

Downstream 100 bases:

>100_bases
AGTTAAGAACCTGTCTATTATAGAAAAAAGTGAAGTACTGATGCATTTTTCGATTCGTTTATCCGATGGATCTGCCGTTG
ACAGTACTAAAATTTCCAAC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MAEIIEKSGLRWLWLAAIMLALDQVTKYWTIQSLDLYESYEIFSFFSFTYARNYGAAFSFLGDAGGWQRYLFTAIAIVVS
SYLVYLLKKNASTDRWINCAYALILSGALGNVVDRMMFGYVIDFLDFDLGFYRWPTFNIADSAIFTGAVIMIFESFFAKQ
AKPIKQPKGNKNV

Sequences:

>Translated_173_residues
MAEIIEKSGLRWLWLAAIMLALDQVTKYWTIQSLDLYESYEIFSFFSFTYARNYGAAFSFLGDAGGWQRYLFTAIAIVVS
SYLVYLLKKNASTDRWINCAYALILSGALGNVVDRMMFGYVIDFLDFDLGFYRWPTFNIADSAIFTGAVIMIFESFFAKQ
AKPIKQPKGNKNV
>Mature_172_residues
AEIIEKSGLRWLWLAAIMLALDQVTKYWTIQSLDLYESYEIFSFFSFTYARNYGAAFSFLGDAGGWQRYLFTAIAIVVSS
YLVYLLKKNASTDRWINCAYALILSGALGNVVDRMMFGYVIDFLDFDLGFYRWPTFNIADSAIFTGAVIMIFESFFAKQA
KPIKQPKGNKNV

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=162, Percent_Identity=45.0617283950617, Blast_Score=153, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_PSYIN (A1SZP2)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944556.1
- STRING:   A1SZP2
- MEROPS:   A08.001
- GeneID:   4626303
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3270
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- PhylomeDB:   A1SZP2
- BioCyc:   PING357804:PING_3270-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19791; Mature: 19660

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x1a155304)-; HASH(0x406778e8)-; HASH(0x1aad0cc0)-; HASH(0x19e9d34c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIIEKSGLRWLWLAAIMLALDQVTKYWTIQSLDLYESYEIFSFFSFTYARNYGAAFSF
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDAGGWQRYLFTAIAIVVSSYLVYLLKKNASTDRWINCAYALILSGALGNVVDRMMFGY
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIDFLDFDLGFYRWPTFNIADSAIFTGAVIMIFESFFAKQAKPIKQPKGNKNV
HHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
AEIIEKSGLRWLWLAAIMLALDQVTKYWTIQSLDLYESYEIFSFFSFTYARNYGAAFSF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDAGGWQRYLFTAIAIVVSSYLVYLLKKNASTDRWINCAYALILSGALGNVVDRMMFGY
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIDFLDFDLGFYRWPTFNIADSAIFTGAVIMIFESFFAKQAKPIKQPKGNKNV
HHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA