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The map label for this gene is maeA [H]

Identifier: 119945447

GI number: 119945447

Start: 2122690

End: 2124405

Strand: Reverse

Name: maeA [H]

Synonym: Ping_1744

Alternate gene names: 119945447

Gene position: 2124405-2122690 (Counterclockwise)

Preceding gene: 119945457

Following gene: 119945445

Centisome position: 46.59

GC content: 40.85

Gene sequence:

>1716_bases
ATGGGTAAAGGTAAATATTTAAAATGGGAAGATTCTGAGGGTAACGTTTTTAGACCTGTTTCCCTTACTGGAAACGAATT
ACTCAACAATAGGACGCTCAATAAGAGTACGGCATTTACTTATCAAGAGCGTGAAGATTTTGATCTTAATGGTCTTTTAC
CACCACGCGTACAAACCTTTGAAGATCAACTGAAACGGGTTTACCAGGGATTTAGCGCTTCCTCTACGGATATTGAAAAA
TACCAATATTTACGTGCCTTGCAGGATAGGAATGAAACATTATTTTATGCCCTTATCTCACGTAATATTGAAGAGATGAC
GCCTATTATCTATACCCCGACGGTAGGTAAAGCCTGTCAAGAATTTAGCCATAGGTTTCAAATAGCCAGAGGACTTTATT
TAACAACGGATAATATTCATGATGTCGGCAGCATGGCACGAGAATTTACAGGTAAAGATATCCAAATTATCGTTGTAACA
GATAGCCAGGGCATTCTTGGCATTGGCGATCAAGGTGTTGGAGGAATGGGCATACCAATTGGTAAATTATCACTTTATAC
CTTAGGTGCCGGTATTCACCCGGATCATTGCATGCCAATCGCATTAGACATAGGGACAGATAATCAGGATTTACTTGCTG
ATCCTATGTATTTAGGGATTCCCAAAAAACGTTTAACAGGTGAACCTTATAAAGCGTTTATTAAAACCTTTGTTGAACAG
GTGAAATTACATTTTCCAAAAGCCGTTTTGCAATGGGAAGATTTCAGTAAATCTAACGCCTTTGATAATTTATCTGATTA
CGAAGATGAGTTGCCATCATTTAATGATGACGTACAAGGCACGGGTGCTGTTGTATTAGCCGGGATAATTGGCTCCACAA
AAATGAAAGGTGAAACATTAATAGATCAGACTTATGCTGTTTACGGCGCAGGAGCAGGTGGTGTTGGTGTTGCCGATCAA
ATTTTTGCGGGTTTACTTAAAGAAGGTCTGTCCCACCAAGAGGCGCGCGATAGAATATTTATCCTTGATTCCCGCGGTGT
GGTGTTTGCAGATAGAGAAGGTTTAGATGAATACAAAAAACGTTTTGCTAAACCTGTTGAGTTAGCAAAAGATTGGCAAC
TGGCAGATAGCAATAAGGTCAATCTTACTGAGTTACTCGATAATGTTCCCGTTACCGTTTTATTAGGCTGCAGTGGTGTA
GGTGGTGCATTTAAAGAGCATCATATTAAGAAAATGTTAGATCATACAGCACGACCTATGATCTTCCCGCTTTCTAACCC
AACCAGTTGTTGTGAAGCGGTGCCGGAAGATATTTATAAGTGGTCCGATGGCCAAGCTATTGTTGCAACGGGCAGTCCTT
TTGCTGATCTGCATTTTAAGGACAATATCTATCGCATCGGACAGGGAAATAACATCTTTATTTTCCCCGGTGTCGGGCTC
GCAGCGATCACTGCTGAAGTGAAAAAAATCACCAAGGATATGTTTACTACTGCCTCTTTTGCATTAGCCGATTATGTGTC
ACAAGAAGATCTTGATGCAGGTTGCGTATTTCCAAAAATTAGTGAGCTGAGAGATGTTTCTCTCCATGTTGCTAAGGCAA
TACTTGAGCAAATTCAGCAAACGGATCCTGAGTGTCATCTGCGTGATAAAGATATCACTAAAGAGCTTGCATTACGGATG
TGGGAACCGGCGTACTTGCCCTACCGCAGAGCTTAA

Upstream 100 bases:

>100_bases
AATACTTTTATTAATGATATTACGGGGTATAGTTCAGTTCATTCGAATGCTTTATCTTAGCTGCCAGTATTCGAATACTA
TAATAATAATGGAGAGCGTA

Downstream 100 bases:

>100_bases
AACCACCAGCCCTGTTAAATAACAGGGCTTTTTTTTAACCGGTAAACGATTATCTCTTCAAAACTCAACTTCCTGAACCA
TCAAAAGAGGATTCACAACC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 2 [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MGKGKYLKWEDSEGNVFRPVSLTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTFEDQLKRVYQGFSASSTDIEK
YQYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQEFSHRFQIARGLYLTTDNIHDVGSMAREFTGKDIQIIVVT
DSQGILGIGDQGVGGMGIPIGKLSLYTLGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQ
VKLHFPKAVLQWEDFSKSNAFDNLSDYEDELPSFNDDVQGTGAVVLAGIIGSTKMKGETLIDQTYAVYGAGAGGVGVADQ
IFAGLLKEGLSHQEARDRIFILDSRGVVFADREGLDEYKKRFAKPVELAKDWQLADSNKVNLTELLDNVPVTVLLGCSGV
GGAFKEHHIKKMLDHTARPMIFPLSNPTSCCEAVPEDIYKWSDGQAIVATGSPFADLHFKDNIYRIGQGNNIFIFPGVGL
AAITAEVKKITKDMFTTASFALADYVSQEDLDAGCVFPKISELRDVSLHVAKAILEQIQQTDPECHLRDKDITKELALRM
WEPAYLPYRRA

Sequences:

>Translated_571_residues
MGKGKYLKWEDSEGNVFRPVSLTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTFEDQLKRVYQGFSASSTDIEK
YQYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQEFSHRFQIARGLYLTTDNIHDVGSMAREFTGKDIQIIVVT
DSQGILGIGDQGVGGMGIPIGKLSLYTLGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQ
VKLHFPKAVLQWEDFSKSNAFDNLSDYEDELPSFNDDVQGTGAVVLAGIIGSTKMKGETLIDQTYAVYGAGAGGVGVADQ
IFAGLLKEGLSHQEARDRIFILDSRGVVFADREGLDEYKKRFAKPVELAKDWQLADSNKVNLTELLDNVPVTVLLGCSGV
GGAFKEHHIKKMLDHTARPMIFPLSNPTSCCEAVPEDIYKWSDGQAIVATGSPFADLHFKDNIYRIGQGNNIFIFPGVGL
AAITAEVKKITKDMFTTASFALADYVSQEDLDAGCVFPKISELRDVSLHVAKAILEQIQQTDPECHLRDKDITKELALRM
WEPAYLPYRRA
>Mature_570_residues
GKGKYLKWEDSEGNVFRPVSLTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTFEDQLKRVYQGFSASSTDIEKY
QYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQEFSHRFQIARGLYLTTDNIHDVGSMAREFTGKDIQIIVVTD
SQGILGIGDQGVGGMGIPIGKLSLYTLGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQV
KLHFPKAVLQWEDFSKSNAFDNLSDYEDELPSFNDDVQGTGAVVLAGIIGSTKMKGETLIDQTYAVYGAGAGGVGVADQI
FAGLLKEGLSHQEARDRIFILDSRGVVFADREGLDEYKKRFAKPVELAKDWQLADSNKVNLTELLDNVPVTVLLGCSGVG
GAFKEHHIKKMLDHTARPMIFPLSNPTSCCEAVPEDIYKWSDGQAIVATGSPFADLHFKDNIYRIGQGNNIFIFPGVGLA
AITAEVKKITKDMFTTASFALADYVSQEDLDAGCVFPKISELRDVSLHVAKAILEQIQQTDPECHLRDKDITKELALRMW
EPAYLPYRRA

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=520, Percent_Identity=39.8076923076923, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI62420882, Length=524, Percent_Identity=37.5954198473282, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI62420880, Length=524, Percent_Identity=37.5954198473282, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI239049447, Length=524, Percent_Identity=37.5954198473282, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI4505145, Length=552, Percent_Identity=35.8695652173913, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI270265879, Length=457, Percent_Identity=38.074398249453, Blast_Score=323, Evalue=3e-88,
Organism=Escherichia coli, GI87081919, Length=551, Percent_Identity=40.8348457350272, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788806, Length=372, Percent_Identity=25.2688172043011, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537199, Length=536, Percent_Identity=38.2462686567164, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322823, Length=561, Percent_Identity=39.9286987522282, Blast_Score=413, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281362674, Length=529, Percent_Identity=37.6181474480151, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281362672, Length=529, Percent_Identity=37.6181474480151, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI21356279, Length=529, Percent_Identity=37.6181474480151, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24646388, Length=522, Percent_Identity=39.272030651341, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24646386, Length=522, Percent_Identity=39.272030651341, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363505, Length=514, Percent_Identity=35.2140077821012, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI78707236, Length=514, Percent_Identity=35.2140077821012, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI78707232, Length=510, Percent_Identity=35.2941176470588, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI281363503, Length=512, Percent_Identity=34.9609375, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI78707240, Length=528, Percent_Identity=33.7121212121212, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI78707242, Length=521, Percent_Identity=34.5489443378119, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI78707238, Length=521, Percent_Identity=34.5489443378119, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI19922384, Length=515, Percent_Identity=27.9611650485437, Blast_Score=235, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63452; Mature: 63321

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00331 MALIC_ENZYMES ; PS00422 GRANINS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGKYLKWEDSEGNVFRPVSLTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTF
CCCCCEEEEECCCCCEEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHH
EDQLKRVYQGFSASSTDIEKYQYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHCCHHHCCCEEECCCHHHHHH
EFSHRFQIARGLYLTTDNIHDVGSMAREFTGKDIQIIVVTDSQGILGIGDQGVGGMGIPI
HHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCCC
GKLSLYTLGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQ
CCEEEEEECCCCCCCCCEEEEEEECCCCHHHHCCCHHCCCCHHHCCCCHHHHHHHHHHHH
VKLHFPKAVLQWEDFSKSNAFDNLSDYEDELPSFNDDVQGTGAVVLAGIIGSTKMKGETL
HHHHCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEHHCCCCCCCCHH
IDQTYAVYGAGAGGVGVADQIFAGLLKEGLSHQEARDRIFILDSRGVVFADREGLDEYKK
HHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEECCCCHHHHHH
RFAKPVELAKDWQLADSNKVNLTELLDNVPVTVLLGCSGVGGAFKEHHIKKMLDHTARPM
HHCCHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCE
IFPLSNPTSCCEAVPEDIYKWSDGQAIVATGSPFADLHFKDNIYRIGQGNNIFIFPGVGL
EEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEEECCCCH
AAITAEVKKITKDMFTTASFALADYVSQEDLDAGCVFPKISELRDVSLHVAKAILEQIQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TDPECHLRDKDITKELALRMWEPAYLPYRRA
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GKGKYLKWEDSEGNVFRPVSLTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTF
CCCCEEEEECCCCCEEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHH
EDQLKRVYQGFSASSTDIEKYQYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHCCHHHCCCEEECCCHHHHHH
EFSHRFQIARGLYLTTDNIHDVGSMAREFTGKDIQIIVVTDSQGILGIGDQGVGGMGIPI
HHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCCC
GKLSLYTLGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQ
CCEEEEEECCCCCCCCCEEEEEEECCCCHHHHCCCHHCCCCHHHCCCCHHHHHHHHHHHH
VKLHFPKAVLQWEDFSKSNAFDNLSDYEDELPSFNDDVQGTGAVVLAGIIGSTKMKGETL
HHHHCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEHHCCCCCCCCHH
IDQTYAVYGAGAGGVGVADQIFAGLLKEGLSHQEARDRIFILDSRGVVFADREGLDEYKK
HHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEECCCCHHHHHH
RFAKPVELAKDWQLADSNKVNLTELLDNVPVTVLLGCSGVGGAFKEHHIKKMLDHTARPM
HHCCHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCE
IFPLSNPTSCCEAVPEDIYKWSDGQAIVATGSPFADLHFKDNIYRIGQGNNIFIFPGVGL
EEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEEECCCCH
AAITAEVKKITKDMFTTASFALADYVSQEDLDAGCVFPKISELRDVSLHVAKAILEQIQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TDPECHLRDKDITKELALRMWEPAYLPYRRA
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377; 12949160 [H]