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The map label for this gene is murC

Identifier: 119944904

GI number: 119944904

Start: 1437340

End: 1438803

Strand: Direct

Name: murC

Synonym: Ping_1148

Alternate gene names: 119944904

Gene position: 1437340-1438803 (Clockwise)

Preceding gene: 119944903

Following gene: 119944905

Centisome position: 31.52

GC content: 43.44

Gene sequence:

>1464_bases
ATGATAAAAATTGACCTAGCCCAAATACGCACTACAGTACCTGAAATGCGTCGTGTTAAACAAATTCATTTTGTGGGAAT
TGGTGGCGCAGGTATGGGCGGCATTGCAGAAGTATTAGCCTATGAAGGTTATAAAATTTCAGGATCTGATATTGCTGAAA
ATCCGGTCGTCAGGCGATTACGTTCACTCGGCGCTGAGATTTTCATTGGTCATCAACAGGATAATATATATGGTGCGTCA
GTGGTGGTTGTTTCAACTGCCATTAATGCTGATAATCCAGAACTATTAGCGGCGCAACAGGCCCGAATTCCGGTGGTGCG
CCGAGCAGAAATGTTGGCTGAATTGATGCGTTATCGTCATGGTGTTGCCGTTTCCGGTACACACGGGAAAACCACTACAA
CAAGCTTAATCGCGAGTATTTATGGGCAAGCTCAACTCGATCCTACTTTTGTGATCGGCGGTCTATTAAATAGCGCAGGC
ACCAATGCAAAATTAGGGCAAAGTCGCTATTTAATCGCAGAAGCTGATGAAAGTGATGCCTCATTTTTACATTTGCAACC
TATGGTTTCAGTAGTGACCAATATTGAAGCTGACCATATGGATACCTACGAAGGAAATTTTGAAGTATTGAAAGATACCT
TTGTTCGCTTTATACAAAACTTGCCTTTTTATGGCACTGCAGTGGTATGCCTTGATGATGCTGTTATTGAACAATTGATC
CCACGTTTTGCGCGACAAACTGTTACTTATGGTTTCCACGAACAAGCGGATGTTCGTATTTCAGATTTCTCACAATGCGT
AAACCGCAGTGAATTTTCAGTTCATAGAATTAATAAACCAGCAATGAAAATTCAGCTTAATCTTCCGGGAAAACATAATG
CATTAAATGCAGCTGCCGCGATCGCTGTCGCAATGGAAGACGATATCGATGATTTCTCCATTTCAAAGGCACTTAATGAA
TTTGCCGGTATTGGCCGTCGTTTTGAACAATACGGGGAATTTGAAACTGGACGTGGTAAAGCTATTTTGGTTGATGATTA
CGGTCACCATCCGACGGAAGTACAAGCAACCATTGATGCTGCGCGCGCGGCTTGGCCGGATAAACGTTTAGTAATGGCTT
ATCAGCCACACCGGTATACAAGAACACGTGATCTCTATGAAGATTTTGCGCATGTCTTAGCGCAAGTAGATCAATTATTA
CTGCTGGATGTCTATGCTGCCGGTGAAACGCCTATCGCCGGCGCTGATAGCCGCTCTTTATGCCGTACTATCCGGCAACG
TAGTGGTAAAGAGCCTATTTTTGTTGCCAGTCCTGAAGTGTTGCCTGCTATGCTGGCGCAGATAATTGACGATGGTGATC
TTGTTTTAACACAGGGGGCTGGCAATATTGGTGCGGTGGTTAAAACATTAGCTGAATTGCAACTCAATATAGAAAAAATG
AAAAAAGCGAGCCGCGTACAATGA

Upstream 100 bases:

>100_bases
TGCAACAGAGAGTGTTGCATCTATCTGTAATCAATTAGTTTAAGCAATACGCAATGACATATTGCTGGCTTACAACTTTA
TTTTAGACAAGTGATTTATT

Downstream 100 bases:

>100_bases
GTTTAGATTTTGGTAAAGTTGCCGTCTTATTTGGTGGTCACAGTGCGGAGCGTGAAGTGTCGTTACGTTCTGGAAAAGCG
GTGTTAAATGCATTGTTGCG

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MIKIDLAQIRTTVPEMRRVKQIHFVGIGGAGMGGIAEVLAYEGYKISGSDIAENPVVRRLRSLGAEIFIGHQQDNIYGAS
VVVVSTAINADNPELLAAQQARIPVVRRAEMLAELMRYRHGVAVSGTHGKTTTTSLIASIYGQAQLDPTFVIGGLLNSAG
TNAKLGQSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGNFEVLKDTFVRFIQNLPFYGTAVVCLDDAVIEQLI
PRFARQTVTYGFHEQADVRISDFSQCVNRSEFSVHRINKPAMKIQLNLPGKHNALNAAAAIAVAMEDDIDDFSISKALNE
FAGIGRRFEQYGEFETGRGKAILVDDYGHHPTEVQATIDAARAAWPDKRLVMAYQPHRYTRTRDLYEDFAHVLAQVDQLL
LLDVYAAGETPIAGADSRSLCRTIRQRSGKEPIFVASPEVLPAMLAQIIDDGDLVLTQGAGNIGAVVKTLAELQLNIEKM
KKASRVQ

Sequences:

>Translated_487_residues
MIKIDLAQIRTTVPEMRRVKQIHFVGIGGAGMGGIAEVLAYEGYKISGSDIAENPVVRRLRSLGAEIFIGHQQDNIYGAS
VVVVSTAINADNPELLAAQQARIPVVRRAEMLAELMRYRHGVAVSGTHGKTTTTSLIASIYGQAQLDPTFVIGGLLNSAG
TNAKLGQSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGNFEVLKDTFVRFIQNLPFYGTAVVCLDDAVIEQLI
PRFARQTVTYGFHEQADVRISDFSQCVNRSEFSVHRINKPAMKIQLNLPGKHNALNAAAAIAVAMEDDIDDFSISKALNE
FAGIGRRFEQYGEFETGRGKAILVDDYGHHPTEVQATIDAARAAWPDKRLVMAYQPHRYTRTRDLYEDFAHVLAQVDQLL
LLDVYAAGETPIAGADSRSLCRTIRQRSGKEPIFVASPEVLPAMLAQIIDDGDLVLTQGAGNIGAVVKTLAELQLNIEKM
KKASRVQ
>Mature_487_residues
MIKIDLAQIRTTVPEMRRVKQIHFVGIGGAGMGGIAEVLAYEGYKISGSDIAENPVVRRLRSLGAEIFIGHQQDNIYGAS
VVVVSTAINADNPELLAAQQARIPVVRRAEMLAELMRYRHGVAVSGTHGKTTTTSLIASIYGQAQLDPTFVIGGLLNSAG
TNAKLGQSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGNFEVLKDTFVRFIQNLPFYGTAVVCLDDAVIEQLI
PRFARQTVTYGFHEQADVRISDFSQCVNRSEFSVHRINKPAMKIQLNLPGKHNALNAAAAIAVAMEDDIDDFSISKALNE
FAGIGRRFEQYGEFETGRGKAILVDDYGHHPTEVQATIDAARAAWPDKRLVMAYQPHRYTRTRDLYEDFAHVLAQVDQLL
LLDVYAAGETPIAGADSRSLCRTIRQRSGKEPIFVASPEVLPAMLAQIIDDGDLVLTQGAGNIGAVVKTLAELQLNIEKM
KKASRVQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=475, Percent_Identity=65.2631578947368, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=26.8817204301075, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PSYIN (A1SU20)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942584.1
- ProteinModelPortal:   A1SU20
- SMR:   A1SU20
- STRING:   A1SU20
- GeneID:   4623889
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1148
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1SU20
- BioCyc:   PING357804:PING_1148-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53381; Mature: 53381

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIDLAQIRTTVPEMRRVKQIHFVGIGGAGMGGIAEVLAYEGYKISGSDIAENPVVRRL
CEEEEHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCCHHHHHH
RSLGAEIFIGHQQDNIYGASVVVVSTAINADNPELLAAQQARIPVVRRAEMLAELMRYRH
HHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCHHEEHHHHCCHHHHHHHHHHHHHHHHC
GVAVSGTHGKTTTTSLIASIYGQAQLDPTFVIGGLLNSAGTNAKLGQSRYLIAEADESDA
CEEEECCCCCHHHHHHHHHHHCCCCCCHHHEEHHHHHCCCCCCCCCCCEEEEEECCCCCC
SFLHLQPMVSVVTNIEADHMDTYEGNFEVLKDTFVRFIQNLPFYGTAVVCLDDAVIEQLI
CEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
PRFARQTVTYGFHEQADVRISDFSQCVNRSEFSVHRINKPAMKIQLNLPGKHNALNAAAA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHH
IAVAMEDDIDDFSISKALNEFAGIGRRFEQYGEFETGRGKAILVDDYGHHPTEVQATIDA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHH
ARAAWPDKRLVMAYQPHRYTRTRDLYEDFAHVLAQVDQLLLLDVYAAGETPIAGADSRSL
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHH
CRTIRQRSGKEPIFVASPEVLPAMLAQIIDDGDLVLTQGAGNIGAVVKTLAELQLNIEKM
HHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
KKASRVQ
HHHHCCC
>Mature Secondary Structure
MIKIDLAQIRTTVPEMRRVKQIHFVGIGGAGMGGIAEVLAYEGYKISGSDIAENPVVRRL
CEEEEHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCCHHHHHH
RSLGAEIFIGHQQDNIYGASVVVVSTAINADNPELLAAQQARIPVVRRAEMLAELMRYRH
HHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCHHEEHHHHCCHHHHHHHHHHHHHHHHC
GVAVSGTHGKTTTTSLIASIYGQAQLDPTFVIGGLLNSAGTNAKLGQSRYLIAEADESDA
CEEEECCCCCHHHHHHHHHHHCCCCCCHHHEEHHHHHCCCCCCCCCCCEEEEEECCCCCC
SFLHLQPMVSVVTNIEADHMDTYEGNFEVLKDTFVRFIQNLPFYGTAVVCLDDAVIEQLI
CEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
PRFARQTVTYGFHEQADVRISDFSQCVNRSEFSVHRINKPAMKIQLNLPGKHNALNAAAA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHH
IAVAMEDDIDDFSISKALNEFAGIGRRFEQYGEFETGRGKAILVDDYGHHPTEVQATIDA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHH
ARAAWPDKRLVMAYQPHRYTRTRDLYEDFAHVLAQVDQLLLLDVYAAGETPIAGADSRSL
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHH
CRTIRQRSGKEPIFVASPEVLPAMLAQIIDDGDLVLTQGAGNIGAVVKTLAELQLNIEKM
HHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
KKASRVQ
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA