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The map label for this gene is prs [H]

Identifier: 119944672

GI number: 119944672

Start: 1140666

End: 1141610

Strand: Reverse

Name: prs [H]

Synonym: Ping_0911

Alternate gene names: 119944672

Gene position: 1141610-1140666 (Counterclockwise)

Preceding gene: 119944673

Following gene: 119944671

Centisome position: 25.04

GC content: 43.7

Gene sequence:

>945_bases
GTGCCAAATATGAAACTATTTGCAGGTAACGCGACACCCGATCTAGCCAAGAAAGTTGCAGAGCGTCTTTTCGTTAAACT
AGGAAGCGCGGATGTTGGGCGCTTTAGCGATGGAGAGATCCACGTACAAATTAATGAGAACGTACGCGGTGATGATATTT
TTATCGTACAGTCTACATGTGCTCCCACCAATGATAATTTAATGGAATTAATCGTTATGATTGACGCACTTCGTCGTGCA
TCAGCCGGACGTATTACTGCCGTTATTCCATACTTTGGTTATGCCCGTCAAGACCGTAGAGTTCGCTCAAGTCGTGTTCC
GATCACTGCAAAAGTGGTTGCAGATTTCCTATCAAATGTTGGTGTAGACCGTGTATTGACCGTTGACCTGCATGCAGAGC
AAATCCAAGGATTTTTTGATGTGCCGGTTGATAATGTATTCGGCAGCTCAGTACTTCTTGAAGATATGTTAGAGAAGAAA
CTGGATAACCCAATGATTGTGTCCCCTGATATTGGCGGTGTTGTTCGTGCGCGTGCACATGCTAAATTACTCGATGATGC
CGATTTGGCGATCATCGACAAACGTCGTCCAAAAGCAAACGTTGCGCAAGTAATGCACTTGATTGGTGATGTTGAAGGAC
GTAACTGTATTATCGTTGATGATATGATAGATACCGGCGGTACATTATGCCAGGCAGCTTTAGCACTTAAAGAGCGCGGT
GCAAGCTCTGTTTACGCTTATGCGACACATGCGGTCTTCTCTGGAAAAGCCGCTGAAAACATCAAAAACTCTGTTATTGA
TGAATTCATTGTTACTGACTCAATTCCGCTTTCAGCAGAAATTATTGCAACGGGTAAAGTTAAGCAGTTAACATTAAGTG
GCATGCTGGCTGAAGCAATTCGTCGCGTCAGTAACGAAGAATCAATCTCTGCAATGTTTCACTAA

Upstream 100 bases:

>100_bases
AAATAAAATTTATTAATTGCATTAAGGTAATTAATAACAAATGTTAATCAGCATTATTGCTTTTTGACACACACCCCTTA
GGATTACAGAGGTCCTCACA

Downstream 100 bases:

>100_bases
TCTCGGTCATCTTCCGCTGTTAATGGCGGTTAAGTAACCCTTTTAACTTTTGTTAATTGTCTTTGAACACAAAAAACACT
TTACTGTTTTACCGGAAAGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPNMKLFAGNATPDLAKKVAERLFVKLGSADVGRFSDGEIHVQINENVRGDDIFIVQSTCAPTNDNLMELIVMIDALRRA
SAGRITAVIPYFGYARQDRRVRSSRVPITAKVVADFLSNVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSSVLLEDMLEKK
LDNPMIVSPDIGGVVRARAHAKLLDDADLAIIDKRRPKANVAQVMHLIGDVEGRNCIIVDDMIDTGGTLCQAALALKERG
ASSVYAYATHAVFSGKAAENIKNSVIDEFIVTDSIPLSAEIIATGKVKQLTLSGMLAEAIRRVSNEESISAMFH

Sequences:

>Translated_314_residues
MPNMKLFAGNATPDLAKKVAERLFVKLGSADVGRFSDGEIHVQINENVRGDDIFIVQSTCAPTNDNLMELIVMIDALRRA
SAGRITAVIPYFGYARQDRRVRSSRVPITAKVVADFLSNVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSSVLLEDMLEKK
LDNPMIVSPDIGGVVRARAHAKLLDDADLAIIDKRRPKANVAQVMHLIGDVEGRNCIIVDDMIDTGGTLCQAALALKERG
ASSVYAYATHAVFSGKAAENIKNSVIDEFIVTDSIPLSAEIIATGKVKQLTLSGMLAEAIRRVSNEESISAMFH
>Mature_313_residues
PNMKLFAGNATPDLAKKVAERLFVKLGSADVGRFSDGEIHVQINENVRGDDIFIVQSTCAPTNDNLMELIVMIDALRRAS
AGRITAVIPYFGYARQDRRVRSSRVPITAKVVADFLSNVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSSVLLEDMLEKKL
DNPMIVSPDIGGVVRARAHAKLLDDADLAIIDKRRPKANVAQVMHLIGDVEGRNCIIVDDMIDTGGTLCQAALALKERGA
SSVYAYATHAVFSGKAAENIKNSVIDEFIVTDSIPLSAEIIATGKVKQLTLSGMLAEAIRRVSNEESISAMFH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=48.5714285714286, Blast_Score=295, Evalue=4e-80,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=47.6340694006309, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=47.6190476190476, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=47.3015873015873, Blast_Score=286, Evalue=1e-77,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=36.6279069767442, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=36.6279069767442, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI310128524, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=80.2547770700637, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=45.7142857142857, Blast_Score=286, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=45.7142857142857, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=45.7142857142857, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.1612903225806, Blast_Score=276, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=35.207100591716, Blast_Score=193, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=44.620253164557, Blast_Score=259, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=47.3186119873817, Blast_Score=258, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=44.2675159235669, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=38.1642512077295, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=39.6396396396396, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=47.3015873015873, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=44.213649851632, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=34.9431818181818, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=34.9431818181818, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=34.9431818181818, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=34.9431818181818, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24651462, Length=181, Percent_Identity=39.2265193370166, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24651464, Length=181, Percent_Identity=39.2265193370166, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI45552010, Length=181, Percent_Identity=39.2265193370166, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34077; Mature: 33945

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNMKLFAGNATPDLAKKVAERLFVKLGSADVGRFSDGEIHVQINENVRGDDIFIVQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMIDALRRASAGRITAVIPYFGYARQDRRVRSSRVPITAKVVADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSSVLLEDMLEKKLDNPMIVSPDIGGVVRARAH
CCCEEEEEEEEHHHHCCEECCCHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHH
AKLLDDADLAIIDKRRPKANVAQVMHLIGDVEGRNCIIVDDMIDTGGTLCQAALALKERG
HHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCHHCCHHHHHHHHHHHHCC
ASSVYAYATHAVFSGKAAENIKNSVIDEFIVTDSIPLSAEIIATGKVKQLTLSGMLAEAI
CCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
RRVSNEESISAMFH
HHHCCCCHHHHHCC
>Mature Secondary Structure 
PNMKLFAGNATPDLAKKVAERLFVKLGSADVGRFSDGEIHVQINENVRGDDIFIVQSTC
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMIDALRRASAGRITAVIPYFGYARQDRRVRSSRVPITAKVVADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSSVLLEDMLEKKLDNPMIVSPDIGGVVRARAH
CCCEEEEEEEEHHHHCCEECCCHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHH
AKLLDDADLAIIDKRRPKANVAQVMHLIGDVEGRNCIIVDDMIDTGGTLCQAALALKERG
HHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCHHCCHHHHHHHHHHHHCC
ASSVYAYATHAVFSGKAAENIKNSVIDEFIVTDSIPLSAEIIATGKVKQLTLSGMLAEAI
CCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
RRVSNEESISAMFH
HHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]