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The map label for this gene is lpxK

Identifier: 119944662

GI number: 119944662

Start: 1131494

End: 1132456

Strand: Direct

Name: lpxK

Synonym: Ping_0901

Alternate gene names: 119944662

Gene position: 1131494-1132456 (Clockwise)

Preceding gene: 119944661

Following gene: 119944663

Centisome position: 24.82

GC content: 41.02

Gene sequence:

>963_bases
ATGCCATTTTGGTACCGCCCTGTTACTTGGGCGTGGTTACTTTTGCCACTGGCTTTACTGTTTAAAATGATCAGTTTCTG
CCGCCGCTTGGCTTATCAAAAAGGTTTTTTTAAACGTTATAAAAGTAAGTTACCTGTTATTATCGTCGGTAATATTTCTG
TTGGTGGTAACGGTAAAACACCTTTTGTTATCTGGTTATGCGAAATGCTAATCACGGTGGGTTACAAACCCGCCGTGATT
AGTCGCGGTTATGGCGGAAAAAGCAACCATTATCCGTTGCTTGTGGGCGATCATATTAAGGGCCATGAGGCGGGTGATGA
GCCGGTCTTAATCCATAAACGCCTGGGGATTCCTGTGGTGGTTGATCCAAACCGTAAAAATGCAGTTAAATATATCGAGC
AGCATTTTTTGGCTGATATCATTATTAGCGATGATGGATTGCAGCATTATGCATTACAACGAGATATTGAAATTGTTATT
GTTGACGGCAAGCGCCGTTTTGGTAACCAGCACCTGATGCCGATCGGTCCATTGCGGGAAAACCTATCACGTTTAAACAG
TGTTGATTTTGTCGTTAATAATGGAGGACAGCAGGTTAATGAAATAACGATGTTGTTAAAGGCACAAAACTGTCAACGTG
TTGATGGAGAAACGGCACAACTTAGCAGCGGTGTTCAAGTCAACGCTTGTGCGGCGATTGGTTATCCGCAACGATTTTTT
GATACGCTTAACCAGCAGCAGTTTGAAATATTAAAAGCCGTCGGTTTTAATGATCATCATGCCTTTTCAAAAGATGATTT
TACTCAATTTGAAGCGTCTATTCCGCTGTTAATGACAGAAAAAGACGCTGTTAAATGCACTGATTTTGCACAGCCAAATT
GGTGGTATTTACCTGTTTCAGCCGAATTTTCGGCGGGCTTTGAACAACAATTATTAAATAGGATTAAGGAAATAAAATGT
TAG

Upstream 100 bases:

>100_bases
ATGATGGTAGCGTCGTCGAGCGTGGTACGCATGCAGAGCTTATTGAGAAAAAAGCGATTTATCACAGCCTTAGCAAAATT
CAAGCGTCTGGAGAGTTATA

Downstream 100 bases:

>100_bases
ACATTAAATTACTTGATATTATCGCCTGTCCATTATGCAAAGGTAAGTTAAGTTATAAAAAAAACAGCAATGAACTTATT
TGTAAGTTTGATCATCTTGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MPFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKTPFVIWLCEMLITVGYKPAVI
SRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVVVDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVI
VDGKRRFGNQHLMPIGPLRENLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFF
DTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVSAEFSAGFEQQLLNRIKEIKC

Sequences:

>Translated_320_residues
MPFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKTPFVIWLCEMLITVGYKPAVI
SRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVVVDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVI
VDGKRRFGNQHLMPIGPLRENLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFF
DTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVSAEFSAGFEQQLLNRIKEIKC
>Mature_319_residues
PFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKTPFVIWLCEMLITVGYKPAVIS
RGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVVVDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVIV
DGKRRFGNQHLMPIGPLRENLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFFD
TLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVSAEFSAGFEQQLLNRIKEIKC

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=307, Percent_Identity=46.5798045602606, Blast_Score=270, Evalue=8e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PSYIN (A1STC8)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942342.1
- STRING:   A1STC8
- GeneID:   4624389
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0901
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   A1STC8
- BioCyc:   PING357804:PING_0901-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36310; Mature: 36178

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC
PFVIWLCEMLITVGYKPAVISRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVV
CHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCEEE
VDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVIVDGKRRFGNQHLMPIGPLRE
ECCCCCHHHHHHHHHHHHEEEECCCCCHHHHHCCCCEEEEECCCHHCCCCCCCCCHHHHH
NLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFF
HHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCHHHH
DTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVS
HHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEECCCCCCEEEEEEC
AEFSAGFEQQLLNRIKEIKC
CCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFWYRPVTWAWLLLPLALLFKMISFCRRLAYQKGFFKRYKSKLPVIIVGNISVGGNGKT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC
PFVIWLCEMLITVGYKPAVISRGYGGKSNHYPLLVGDHIKGHEAGDEPVLIHKRLGIPVV
CHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCEEE
VDPNRKNAVKYIEQHFLADIIISDDGLQHYALQRDIEIVIVDGKRRFGNQHLMPIGPLRE
ECCCCCHHHHHHHHHHHHEEEECCCCCHHHHHCCCCEEEEECCCHHCCCCCCCCCHHHHH
NLSRLNSVDFVVNNGGQQVNEITMLLKAQNCQRVDGETAQLSSGVQVNACAAIGYPQRFF
HHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCHHHH
DTLNQQQFEILKAVGFNDHHAFSKDDFTQFEASIPLLMTEKDAVKCTDFAQPNWWYLPVS
HHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEECCCCCCEEEEEEC
AEFSAGFEQQLLNRIKEIKC
CCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA