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The map label for this gene is clcA [H]

Identifier: 119944627

GI number: 119944627

Start: 1085190

End: 1086602

Strand: Direct

Name: clcA [H]

Synonym: Ping_0866

Alternate gene names: 119944627

Gene position: 1085190-1086602 (Clockwise)

Preceding gene: 119944620

Following gene: 119944628

Centisome position: 23.8

GC content: 44.8

Gene sequence:

>1413_bases
ATGAATAAAAAAACACCAACGTCCTCTGTTAGTATACCAAAGCGTTTTATTACTCATTTTTTTACCCGTAAAAGTAGTGC
CTTACTTATCTGGTTATCGGCCATTATTGGTATTTTAGCGGGTGCCATGTCAGCGCTGTTTGACCATGGTATTATCTGGA
TCAGCGAATTACGTTTACAGTTAATTGCCTCTTTTGGTGACTCGGATATTCCGCTGTGGATCGTTGCTATCCCCATTTCC
TCGTTTATGGCAGGTCTTGCATTTTACCTTACTCATCGATTTGCCCCTGAAGCGGGTGGCAGTGGTATTCCTGAAATAGA
AGGTGCGATGGAAGGAATGCGACCGGTGCGTTGGAAAAGAGTTATTCCGGTGAAGTTTTTTGGCGGTCTCCTCGCGCTCG
GCAGTGGTATGGCATTGGGGAGAGAGGGGCCTTCCGTGCAAATGGGCGGCAATATCGGGCGTATGATTTCTGACATTTTT
AAAGTAGATCAGGCAGATGCTCAGGCGCTGTTAGCTGCCGGGGCAGCCGGTGGATTAGCGGCTGCATTTAATGCACCCCT
TGCGGGCATTATGTTTGTTATCGAAGAGATGCGTTCACAATTTAATTACAGTTTAACCTCTACAAAAAGTGTTTTTATGA
GCGCTGTAATGGCCACGATCGTAATGCGCTTTATGTCTGGTCAAGATGCGGTGATCAGCGTAACCCACTATTCACATCCT
GATTTACTGTCATTATGGTTATATTTATTATTGGGTTTTTGTTTTGGCGTAATTGGGCTTTTCTTTAATAAGCTGTTGCT
TGCAGCGCAAGATATGTATCTCTTTATACATAAAAATAAACGCTGGCGCTTTGTCTCCGTTGGTTTGTTTTTGGGGGCGG
TTTTTGGCGCTTTATCGGTATTAGAGCCGCAGTTAGCTTATAGTGGCCTGGAGTTAATTCCCGAGATCGCTGGTGGGCAT
TATCTTTCTGGTGCTCTAATGATTATTTTTTTATTTCGTATCGTCACAACCTTAGCAAGCTTCGGCTCAGGTGCGCCTGG
CGGTGTTTTTGCTCCAACCTTAGCGTTAGGCACCTTATTTGGCATGTTATTTGGACTCGCATGCCATGCTTTATTTCCCG
AACTTGTCACTGAACCAGGCAGATTTGCTATTGCCGGGATGGGCGGGTTATTTGCCGCATCGGTTCGTGCACCGATCACC
GGGATATTGTTAGTGATTGAAATGACTAGTAATTATGAGATGATTTTACCCTTAATAGTGACCTGTTTAGGAGCCACTAT
GGTCGCGCAAACGCTTGGCGGACGTCCAATTTATACGCAATTATTAGAACGGACAATGCGCATTTCAATGCGCCAAAAAC
GTCAAGAGCAAGCGCGTAAAGCAATGGTTCATCTCGAGCGTAATCAAAGATAA

Upstream 100 bases:

>100_bases
GTAGCGATATTTTTATATAATGTTCATCCTGTATTCACGTTTGCGGCTTTTTGAGCGACGAGTTGCACTCTCCTTATCTT
GAAATAGTTGTATTTATTTA

Downstream 100 bases:

>100_bases
TTTTTGATCATTTTTTTGAATCTTTCGACGATAGATAATTTAACTTTATTTGGTAGAGTTAATACTTGAACTAATTAGTC
AGGTACTAGATAATGTTATT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MNKKTPTSSVSIPKRFITHFFTRKSSALLIWLSAIIGILAGAMSALFDHGIIWISELRLQLIASFGDSDIPLWIVAIPIS
SFMAGLAFYLTHRFAPEAGGSGIPEIEGAMEGMRPVRWKRVIPVKFFGGLLALGSGMALGREGPSVQMGGNIGRMISDIF
KVDQADAQALLAAGAAGGLAAAFNAPLAGIMFVIEEMRSQFNYSLTSTKSVFMSAVMATIVMRFMSGQDAVISVTHYSHP
DLLSLWLYLLLGFCFGVIGLFFNKLLLAAQDMYLFIHKNKRWRFVSVGLFLGAVFGALSVLEPQLAYSGLELIPEIAGGH
YLSGALMIIFLFRIVTTLASFGSGAPGGVFAPTLALGTLFGMLFGLACHALFPELVTEPGRFAIAGMGGLFAASVRAPIT
GILLVIEMTSNYEMILPLIVTCLGATMVAQTLGGRPIYTQLLERTMRISMRQKRQEQARKAMVHLERNQR

Sequences:

>Translated_470_residues
MNKKTPTSSVSIPKRFITHFFTRKSSALLIWLSAIIGILAGAMSALFDHGIIWISELRLQLIASFGDSDIPLWIVAIPIS
SFMAGLAFYLTHRFAPEAGGSGIPEIEGAMEGMRPVRWKRVIPVKFFGGLLALGSGMALGREGPSVQMGGNIGRMISDIF
KVDQADAQALLAAGAAGGLAAAFNAPLAGIMFVIEEMRSQFNYSLTSTKSVFMSAVMATIVMRFMSGQDAVISVTHYSHP
DLLSLWLYLLLGFCFGVIGLFFNKLLLAAQDMYLFIHKNKRWRFVSVGLFLGAVFGALSVLEPQLAYSGLELIPEIAGGH
YLSGALMIIFLFRIVTTLASFGSGAPGGVFAPTLALGTLFGMLFGLACHALFPELVTEPGRFAIAGMGGLFAASVRAPIT
GILLVIEMTSNYEMILPLIVTCLGATMVAQTLGGRPIYTQLLERTMRISMRQKRQEQARKAMVHLERNQR
>Mature_470_residues
MNKKTPTSSVSIPKRFITHFFTRKSSALLIWLSAIIGILAGAMSALFDHGIIWISELRLQLIASFGDSDIPLWIVAIPIS
SFMAGLAFYLTHRFAPEAGGSGIPEIEGAMEGMRPVRWKRVIPVKFFGGLLALGSGMALGREGPSVQMGGNIGRMISDIF
KVDQADAQALLAAGAAGGLAAAFNAPLAGIMFVIEEMRSQFNYSLTSTKSVFMSAVMATIVMRFMSGQDAVISVTHYSHP
DLLSLWLYLLLGFCFGVIGLFFNKLLLAAQDMYLFIHKNKRWRFVSVGLFLGAVFGALSVLEPQLAYSGLELIPEIAGGH
YLSGALMIIFLFRIVTTLASFGSGAPGGVFAPTLALGTLFGMLFGLACHALFPELVTEPGRFAIAGMGGLFAASVRAPIT
GILLVIEMTSNYEMILPLIVTCLGATMVAQTLGGRPIYTQLLERTMRISMRQKRQEQARKAMVHLERNQR

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=417, Percent_Identity=25.6594724220624, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI55770840, Length=417, Percent_Identity=25.6594724220624, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI153252026, Length=506, Percent_Identity=23.7154150197628, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557473, Length=441, Percent_Identity=25.1700680272109, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI189217923, Length=441, Percent_Identity=25.1700680272109, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI189217921, Length=441, Percent_Identity=25.1700680272109, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI283806622, Length=413, Percent_Identity=25.6658595641646, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI156104869, Length=413, Percent_Identity=25.6658595641646, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786350, Length=446, Percent_Identity=48.8789237668161, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI87081943, Length=322, Percent_Identity=31.9875776397516, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532615, Length=508, Percent_Identity=24.6062992125984, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71980828, Length=508, Percent_Identity=23.4251968503937, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980824, Length=508, Percent_Identity=23.4251968503937, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980820, Length=513, Percent_Identity=23.1968810916179, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985148, Length=480, Percent_Identity=23.9583333333333, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71985141, Length=480, Percent_Identity=23.9583333333333, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996452, Length=488, Percent_Identity=22.3360655737705, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71996455, Length=488, Percent_Identity=22.3360655737705, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=524, Percent_Identity=24.8091603053435, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322500, Length=411, Percent_Identity=24.330900243309, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24665008, Length=502, Percent_Identity=24.3027888446215, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551566, Length=488, Percent_Identity=24.3852459016393, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281361606, Length=448, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161078208, Length=448, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573073, Length=448, Percent_Identity=25, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281361608, Length=448, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573075, Length=448, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573071, Length=448, Percent_Identity=25, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 50862; Mature: 50862

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00358 RIBOSOMAL_L5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKTPTSSVSIPKRFITHFFTRKSSALLIWLSAIIGILAGAMSALFDHGIIWISELRLQ
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIASFGDSDIPLWIVAIPISSFMAGLAFYLTHRFAPEAGGSGIPEIEGAMEGMRPVRWKR
HHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHE
VIPVKFFGGLLALGSGMALGREGPSVQMGGNIGRMISDIFKVDQADAQALLAAGAAGGLA
ECHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCCHH
AAFNAPLAGIMFVIEEMRSQFNYSLTSTKSVFMSAVMATIVMRFMSGQDAVISVTHYSHP
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DLLSLWLYLLLGFCFGVIGLFFNKLLLAAQDMYLFIHKNKRWRFVSVGLFLGAVFGALSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHH
LEPQLAYSGLELIPEIAGGHYLSGALMIIFLFRIVTTLASFGSGAPGGVFAPTLALGTLF
HCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GMLFGLACHALFPELVTEPGRFAIAGMGGLFAASVRAPITGILLVIEMTSNYEMILPLIV
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHH
TCLGATMVAQTLGGRPIYTQLLERTMRISMRQKRQEQARKAMVHLERNQR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKKTPTSSVSIPKRFITHFFTRKSSALLIWLSAIIGILAGAMSALFDHGIIWISELRLQ
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIASFGDSDIPLWIVAIPISSFMAGLAFYLTHRFAPEAGGSGIPEIEGAMEGMRPVRWKR
HHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHE
VIPVKFFGGLLALGSGMALGREGPSVQMGGNIGRMISDIFKVDQADAQALLAAGAAGGLA
ECHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCCHH
AAFNAPLAGIMFVIEEMRSQFNYSLTSTKSVFMSAVMATIVMRFMSGQDAVISVTHYSHP
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DLLSLWLYLLLGFCFGVIGLFFNKLLLAAQDMYLFIHKNKRWRFVSVGLFLGAVFGALSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHH
LEPQLAYSGLELIPEIAGGHYLSGALMIIFLFRIVTTLASFGSGAPGGVFAPTLALGTLF
HCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GMLFGLACHALFPELVTEPGRFAIAGMGGLFAASVRAPITGILLVIEMTSNYEMILPLIV
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHH
TCLGATMVAQTLGGRPIYTQLLERTMRISMRQKRQEQARKAMVHLERNQR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA