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The map label for this gene is ilvY [H]

Identifier: 119944616

GI number: 119944616

Start: 1073173

End: 1074054

Strand: Direct

Name: ilvY [H]

Synonym: Ping_0855

Alternate gene names: 119944616

Gene position: 1073173-1074054 (Clockwise)

Preceding gene: 119944615

Following gene: 119944617

Centisome position: 23.54

GC content: 44.56

Gene sequence:

>882_bases
ATGGATATTAAATCTCTGCAGCTTTTTGTGCATCTGGCCAGCAGCCTGCATTTTTCTAAAACGGCACAGGCGATGCACGT
TAGCCCATCAACCCTGAGTCGTAATATCCAGCGTATTGAGGAGGAATTAAGTACTGTCCTGTTTGTTCGTGATAATCGCT
CGGTTGTTTTAACCGAAGCAGGGGTCCTGTTTAAACATTATGCACTGCAGCAGATTGAACAGTGGCTGTTACTAAAACGG
GCTATCAATCAAAGTAAAAGTGAGTTGGAAGGGCAGATCAACCTGTATTGTTCAGTGACGGCAGTTTATAGCCACTTGCC
ACCCATTTTAGAACGTTTTCGACGCTTACATCCTAAGGTTGAAATTAAGCTCAGCACCGGGGACAGTGAACGGGCGATTG
ATCAGGTATTAGGAGATCAGGTTGATTTTGCTATCACTGCGCATCCGGATAATTTATCGACACGGTTGCACTTTATAAAA
CTGGCTGAAATACCGCTCTCTATTATTGCGCCAACCACTCCCTGTGCGGTGACACAGCAAGTTAATCAAGCGAAAATTGA
TTGGCAAAATATCACTTTTATTTTGCCTGAACATGGGGCTATTCGTCGTCGTTTTGATAATTGGTATCGTCTGTTAAAAG
TTGGTAAACCACAAATTTATGCCACGGTCGCCGGGCATGAGGCCTTGGTCAGTATGGTCGCATTGGGTTGTGGTGTCGGT
ATTGCACCCGATATAGTGGTTGAAAATAGCCCGGTACGGGATCGGGTACAAAATATATCTACCCCGGTACCGCTGCAGTC
CTTTAATTTAGGCATTTGCTGTTATAAAACACGGGTAAACGAGGCGTTAATCAGTGCTTTCATCGGTTGCATAGAAGGAT
AA

Upstream 100 bases:

>100_bases
TTTTTATCCACGCTTTGAACCAATGAAGCTATCTTATTGATATAGAAAATCAGAAAGTTTCGTGCCATCTTTAAAATTAA
AAACTACGGAATCGAGTTAA

Downstream 100 bases:

>100_bases
GCCGTATTTGAATGTCGAAATACAAGTTTGTTTAGGTTATTCTGTTGGTCATTAAAATAAGAGTATCTGTTTATGAGCAA
TATCGAAGTTACAAACGTCG

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDIKSLQLFVHLASSLHFSKTAQAMHVSPSTLSRNIQRIEEELSTVLFVRDNRSVVLTEAGVLFKHYALQQIEQWLLLKR
AINQSKSELEGQINLYCSVTAVYSHLPPILERFRRLHPKVEIKLSTGDSERAIDQVLGDQVDFAITAHPDNLSTRLHFIK
LAEIPLSIIAPTTPCAVTQQVNQAKIDWQNITFILPEHGAIRRRFDNWYRLLKVGKPQIYATVAGHEALVSMVALGCGVG
IAPDIVVENSPVRDRVQNISTPVPLQSFNLGICCYKTRVNEALISAFIGCIEG

Sequences:

>Translated_293_residues
MDIKSLQLFVHLASSLHFSKTAQAMHVSPSTLSRNIQRIEEELSTVLFVRDNRSVVLTEAGVLFKHYALQQIEQWLLLKR
AINQSKSELEGQINLYCSVTAVYSHLPPILERFRRLHPKVEIKLSTGDSERAIDQVLGDQVDFAITAHPDNLSTRLHFIK
LAEIPLSIIAPTTPCAVTQQVNQAKIDWQNITFILPEHGAIRRRFDNWYRLLKVGKPQIYATVAGHEALVSMVALGCGVG
IAPDIVVENSPVRDRVQNISTPVPLQSFNLGICCYKTRVNEALISAFIGCIEG
>Mature_293_residues
MDIKSLQLFVHLASSLHFSKTAQAMHVSPSTLSRNIQRIEEELSTVLFVRDNRSVVLTEAGVLFKHYALQQIEQWLLLKR
AINQSKSELEGQINLYCSVTAVYSHLPPILERFRRLHPKVEIKLSTGDSERAIDQVLGDQVDFAITAHPDNLSTRLHFIK
LAEIPLSIIAPTTPCAVTQQVNQAKIDWQNITFILPEHGAIRRRFDNWYRLLKVGKPQIYATVAGHEALVSMVALGCGVG
IAPDIVVENSPVRDRVQNISTPVPLQSFNLGICCYKTRVNEALISAFIGCIEG

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=289, Percent_Identity=50.1730103806228, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1787806, Length=259, Percent_Identity=27.4131274131274, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788887, Length=248, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787601, Length=237, Percent_Identity=26.5822784810127, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI157672245, Length=211, Percent_Identity=26.0663507109005, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=25.3676470588235, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=23.7354085603113, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788481, Length=265, Percent_Identity=25.6603773584906, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789440, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367136, Length=121, Percent_Identity=33.0578512396694, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=24.6031746031746, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788297, Length=268, Percent_Identity=24.2537313432836, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786508, Length=178, Percent_Identity=28.0898876404494, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693193, Length=146, Percent_Identity=31.5068493150685, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32770; Mature: 32770

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKSLQLFVHLASSLHFSKTAQAMHVSPSTLSRNIQRIEEELSTVLFVRDNRSVVLTEA
CCHHHHHHHHHHHHHCCHHHHHHHEECCHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEC
GVLFKHYALQQIEQWLLLKRAINQSKSELEGQINLYCSVTAVYSHLPPILERFRRLHPKV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEEHHHHHHHCHHHHHHHHHHCCEE
EIKLSTGDSERAIDQVLGDQVDFAITAHPDNLSTRLHFIKLAEIPLSIIAPTTPCAVTQQ
EEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHEEEEEEECCCEEEECCCCCHHHHHH
VNQAKIDWQNITFILPEHGAIRRRFDNWYRLLKVGKPQIYATVAGHEALVSMVALGCGVG
HHHHEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCC
IAPDIVVENSPVRDRVQNISTPVPLQSFNLGICCYKTRVNEALISAFIGCIEG
CCCCEEECCCCHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIKSLQLFVHLASSLHFSKTAQAMHVSPSTLSRNIQRIEEELSTVLFVRDNRSVVLTEA
CCHHHHHHHHHHHHHCCHHHHHHHEECCHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEC
GVLFKHYALQQIEQWLLLKRAINQSKSELEGQINLYCSVTAVYSHLPPILERFRRLHPKV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEEEEHHHHHHHCHHHHHHHHHHCCEE
EIKLSTGDSERAIDQVLGDQVDFAITAHPDNLSTRLHFIKLAEIPLSIIAPTTPCAVTQQ
EEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHEEEEEEECCCEEEECCCCCHHHHHH
VNQAKIDWQNITFILPEHGAIRRRFDNWYRLLKVGKPQIYATVAGHEALVSMVALGCGVG
HHHHEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCC
IAPDIVVENSPVRDRVQNISTPVPLQSFNLGICCYKTRVNEALISAFIGCIEG
CCCCEEECCCCHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]