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The map label for this gene is ilvC [H]

Identifier: 119944614

GI number: 119944614

Start: 1070256

End: 1071737

Strand: Reverse

Name: ilvC [H]

Synonym: Ping_0853

Alternate gene names: 119944614

Gene position: 1071737-1070256 (Counterclockwise)

Preceding gene: 119944621

Following gene: 119944613

Centisome position: 23.51

GC content: 41.7

Gene sequence:

>1482_bases
ATGGCTAACTATTTTAATACCCTTTCTCTACGTGAAAAGCTAAATCAACTAGGTCAATGTCGTTTTATGGATCGCAGTGA
ATTTACCGACGGTTGTGACGCTTTAAAAGGTAAAAAAGTAGTCATTATCGGTTGTGGTGCTCAGGGTTTAAACCAAGGTT
TAAACATGCGGGATTCGGGTCTTGACGTCTCTTACACGCTGCGTGCACAAGCCATTGCAGAAAAACGTCAATCATGGAAA
AATGCAACTGAAAACGGCTTTGTGGTTGGCACATACGAAGAACTTATTCCTGAAGCCGACCTTTTATGTAACTTAACACC
GGACAAACAGCACACAGCTGTTGTTGGTGCAGTTATGCCCTTAATGAAAGAAGGTGCAACACTGTCTTACTCTCACGGTT
TTAACATCGTTGAAGAAGGTATGCAGGTCCGTGAAGATTTAACCGTTATTATGTGTGCGCCTAAATGTCCTGGTTCTGAA
GTGCGCGAAGAATACAAACGTGGTTTTGGTGTGCCAACACTGATCGCTGTTCACCCGGCAAACGATCCGCAAGGTCAGGG
TTTGGTATGGGCTAAAGCCTATGCAAGTGCAACGGGTGGCGATCGCGCCGGTGTGCTTATGTCATCATTTGTGGCAGAAG
TTAAATCTGACCTGATGGGTGAGCAAACTATCCTTTGTGGTATGTTACAAACTGGTGCCATTATTGGTTATGAAAAAATG
GTTGCCGATGGTATTGAACCAGGATATGCATCAAAACTGATTCAATACGGTTGGGAAACGGTAACAGAAGGCATGAAATA
CGGCGGCATCACTAATATGATGGACCGTTTATCAAATCCTGCAAAAATCAAAGCATTTGATATGTCTTTAGAGCTAAAAG
AGATTTTACGTCCGCTATTTAACAAGCACATGGATGATATTATTGAAGGTGAATTCTCCCGCACTATGATGGAAGATTGG
GCCAACGATGATAAAAATCTTTTACAATGGCGCGCTGAAACGGCTGAAACGGGTTTTGAAAAACAACCTGCAGGCGACAT
GAAAATTGATGAGCAGGAATTCTACGACAACGGTATTTTTCTTATTGCGATGATTAAAGCGGGTGTTGAACTGGCGTTTG
ATGCAATGACAGCTTCCGGCATTATTGCAGACTCAGCTTATTATGAATCACTGCATGAAACTCCGCTTATCGCCAATACT
ATTGCACGTAAAAAACTGTACGAAATGAATGTTGTTATCTCAGATACAGCAGAATACGGTTGTTACCTGTTTGATCATGC
TGCTAAGCCACTACTTGCTGATTTTGTTAAAGCATTAGATCCTGAAATGCTGGGTAAACCTTTAACAGTGAAAAATAATG
CTGTTGATAATGCACGCCTAATCGAAGTTAATGAAGCCATTCGTTCTCACCCTGTCGAAATCGTTGGTAAAAAACTACGC
GGTTACATGACCGAGATGAAAACAATAATAACAGCTTCTTAA

Upstream 100 bases:

>100_bases
TTGTGCAATATAAGTTATAGGCTATAGTACTTATTCAAAATTAAAAGCAATGATTGTTATCTGCTTTAATCCCTATCAAC
TATTTTTGGAGTGTCATTCA

Downstream 100 bases:

>100_bases
TTAGCCCCTTTAGTTAAAACTGACCAAGCCAGAATTTGATTCTGGCTTTTTTTTGCTCTTTTTTTAGAACTACGACTTTG
CTTACGCCAGTGGGTTTTGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MANYFNTLSLREKLNQLGQCRFMDRSEFTDGCDALKGKKVVIIGCGAQGLNQGLNMRDSGLDVSYTLRAQAIAEKRQSWK
NATENGFVVGTYEELIPEADLLCNLTPDKQHTAVVGAVMPLMKEGATLSYSHGFNIVEEGMQVREDLTVIMCAPKCPGSE
VREEYKRGFGVPTLIAVHPANDPQGQGLVWAKAYASATGGDRAGVLMSSFVAEVKSDLMGEQTILCGMLQTGAIIGYEKM
VADGIEPGYASKLIQYGWETVTEGMKYGGITNMMDRLSNPAKIKAFDMSLELKEILRPLFNKHMDDIIEGEFSRTMMEDW
ANDDKNLLQWRAETAETGFEKQPAGDMKIDEQEFYDNGIFLIAMIKAGVELAFDAMTASGIIADSAYYESLHETPLIANT
IARKKLYEMNVVISDTAEYGCYLFDHAAKPLLADFVKALDPEMLGKPLTVKNNAVDNARLIEVNEAIRSHPVEIVGKKLR
GYMTEMKTIITAS

Sequences:

>Translated_493_residues
MANYFNTLSLREKLNQLGQCRFMDRSEFTDGCDALKGKKVVIIGCGAQGLNQGLNMRDSGLDVSYTLRAQAIAEKRQSWK
NATENGFVVGTYEELIPEADLLCNLTPDKQHTAVVGAVMPLMKEGATLSYSHGFNIVEEGMQVREDLTVIMCAPKCPGSE
VREEYKRGFGVPTLIAVHPANDPQGQGLVWAKAYASATGGDRAGVLMSSFVAEVKSDLMGEQTILCGMLQTGAIIGYEKM
VADGIEPGYASKLIQYGWETVTEGMKYGGITNMMDRLSNPAKIKAFDMSLELKEILRPLFNKHMDDIIEGEFSRTMMEDW
ANDDKNLLQWRAETAETGFEKQPAGDMKIDEQEFYDNGIFLIAMIKAGVELAFDAMTASGIIADSAYYESLHETPLIANT
IARKKLYEMNVVISDTAEYGCYLFDHAAKPLLADFVKALDPEMLGKPLTVKNNAVDNARLIEVNEAIRSHPVEIVGKKLR
GYMTEMKTIITAS
>Mature_492_residues
ANYFNTLSLREKLNQLGQCRFMDRSEFTDGCDALKGKKVVIIGCGAQGLNQGLNMRDSGLDVSYTLRAQAIAEKRQSWKN
ATENGFVVGTYEELIPEADLLCNLTPDKQHTAVVGAVMPLMKEGATLSYSHGFNIVEEGMQVREDLTVIMCAPKCPGSEV
REEYKRGFGVPTLIAVHPANDPQGQGLVWAKAYASATGGDRAGVLMSSFVAEVKSDLMGEQTILCGMLQTGAIIGYEKMV
ADGIEPGYASKLIQYGWETVTEGMKYGGITNMMDRLSNPAKIKAFDMSLELKEILRPLFNKHMDDIIEGEFSRTMMEDWA
NDDKNLLQWRAETAETGFEKQPAGDMKIDEQEFYDNGIFLIAMIKAGVELAFDAMTASGIIADSAYYESLHETPLIANTI
ARKKLYEMNVVISDTAEYGCYLFDHAAKPLLADFVKALDPEMLGKPLTVKNNAVDNARLIEVNEAIRSHPVEIVGKKLRG
YMTEMKTIITAS

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=70.9349593495935, Blast_Score=723, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=294, Percent_Identity=31.9727891156463, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54401; Mature: 54270

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLSLREKLNQLGQCRFMDRSEFTDGCDALKGKKVVIIGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHCEEECCCCCCCCCHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYTLRAQAIAEKRQSWKNATENGFVVGTYEELIPEADLLCNLTPDKQHTAVVGAVMP
CCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHEEECCCCCHHHHHHHHHHH
LMKEGATLSYSHGFNIVEEGMQVREDLTVIMCAPKCPGSEVREEYKRGFGVPTLIAVHPA
HHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECC
NDPQGQGLVWAKAYASATGGDRAGVLMSSFVAEVKSDLMGEQTILCGMLQTGAIIGYEKM
CCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHH
VADGIEPGYASKLIQYGWETVTEGMKYGGITNMMDRLSNPAKIKAFDMSLELKEILRPLF
HHCCCCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHH
NKHMDDIIEGEFSRTMMEDWANDDKNLLQWRAETAETGFEKQPAGDMKIDEQEFYDNGIF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEE
LIAMIKAGVELAFDAMTASGIIADSAYYESLHETPLIANTIARKKLYEMNVVISDTAEYG
EEEEHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCHHC
CYLFDHAAKPLLADFVKALDPEMLGKPLTVKNNAVDNARLIEVNEAIRSHPVEIVGKKLR
EEHHHHHCCHHHHHHHHHHCHHHCCCCCEEECCCCCCCEEEEHHHHHHHCCHHHHHHHHH
GYMTEMKTIITAS
HHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLSLREKLNQLGQCRFMDRSEFTDGCDALKGKKVVIIGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHCEEECCCCCCCCCHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDVSYTLRAQAIAEKRQSWKNATENGFVVGTYEELIPEADLLCNLTPDKQHTAVVGAVMP
CCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHEEECCCCCHHHHHHHHHHH
LMKEGATLSYSHGFNIVEEGMQVREDLTVIMCAPKCPGSEVREEYKRGFGVPTLIAVHPA
HHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECC
NDPQGQGLVWAKAYASATGGDRAGVLMSSFVAEVKSDLMGEQTILCGMLQTGAIIGYEKM
CCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHH
VADGIEPGYASKLIQYGWETVTEGMKYGGITNMMDRLSNPAKIKAFDMSLELKEILRPLF
HHCCCCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHH
NKHMDDIIEGEFSRTMMEDWANDDKNLLQWRAETAETGFEKQPAGDMKIDEQEFYDNGIF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEE
LIAMIKAGVELAFDAMTASGIIADSAYYESLHETPLIANTIARKKLYEMNVVISDTAEYG
EEEEHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCHHC
CYLFDHAAKPLLADFVKALDPEMLGKPLTVKNNAVDNARLIEVNEAIRSHPVEIVGKKLR
EEHHHHHCCHHHHHHHHHHCHHHCCCCCEEECCCCCCCEEEEHHHHHHHCCHHHHHHHHH
GYMTEMKTIITAS
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA