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The map label for this gene is groL1

Identifier: 119944606

GI number: 119944606

Start: 1053574

End: 1055208

Strand: Direct

Name: groL1

Synonym: Ping_0844

Alternate gene names: 119944606

Gene position: 1053574-1055208 (Clockwise)

Preceding gene: 119944605

Following gene: 119944607

Centisome position: 23.11

GC content: 42.87

Gene sequence:

>1635_bases
ATGTCTAAAGAAATTAAATTTGGAAATGATTCTCGTAGCAAAATGTTAAACGGCGTTAATATCTTAGCCGATGCAGTTAA
AATCACTTTAGGGCCAAAGGGTCGTAATGTTGTGATCGATAAAAGTTACGGTGCGCCACAAATTACCAAAGACGGTGTCA
CGGTTGCTAAAGAAATTGAACTGGAAGATAAGTTTGAAAACATGGGCGCACAGATGGTAAAAGATGTTGCGTCACAAACT
AATGATGCTGCCGGTGACGGAACAACAACGGCAACCGTATTGGCGCAGGCTATTATTGCTGATGGTTTAAAAGCCGTTGC
TGCTGGTATGAATCCAATGGATTTAAAACGCGGTATTGATCAAACCGTAAAAGCGGCTGTTGCTGAGTTAAAAAAATTAT
CTACACCTTGTTCAGATTCAAAAGCCATCACACAGGTAGGCACTATCTCAGCCAACTCGGATCATGAAATTGGTGAAATC
ATTGCGCAAGCGATGCAAAAAGTTGGTAACCAGGGTGTTATCACGGTAGAAGAAGGTCAAGGTCTAGAAACTGAATTAGA
CGTGGTTGAAGGTATGCAGTTTGATCGTGGTTACCTGTCTCCTTACTTTATGACAAATCATGAATCCGGTACGGTTGAAC
TTGAAAACCCGTATATTTTATTAGTTGATAAAAAAATCGGTAATATTCGTGAATTATTGCCTACATTAGAAGCCGTTGCA
AAAGCCTCTAAGCCATTACTGATTATTGCAGAAGATGTAGAAGGTGAAGCATTAGCAACATTAGTAGTCAACAATATGCG
TGGTATCGTTAAAGTCTGCGCCGTTAAAGCACCTGGTTTTGGTGATCGCCGTAAAGCAATGTTACAAGATATTGCCACAT
TAACGGGCGGTACGGTTATCTCTGAAGAGATTGGTTTGGATATGGAAAAAGTCCAACTTGAAGATTTAGGTCAGGCTAAA
CGTGTTGTGATCAACAAAGATGAAACCACTATTATTGATGGTATTGGTGACGAGTCCGTTATCAATGCACGAGTAAGCCA
AATTAAACAACAAATTGAAGCTTCCACGTCTGACTACGATAAAGAAAAACTGCAGGAACGTTCAGCTAAATTAGCTGGTG
GTGTTGCGGTTATTAAAGTTGGCGCATCCACTGAAGTTGAAATGAAAGAGAAAAAAGATCGCGTAGATGATGCATTGCAT
GCAACACGTGCTGCGGTTGAAGAAGGTGTTGTTGCCGGTGGTGGTGTTGCTCTGGTACGTGTCGCTGCTATATTAAAAGG
CTTAACGGGTGAGAACGAAGATCAGAATGTGGGTATTCGTGTTGCACTGCGCGCCATGGAAGCACCATTGCGTCAAATCG
TAGAAAACTGCGGTGAAGAAGCTTCTGTTGTAGCAAACAATGTGCGCCAGGGTGAAGGAAACTACGGTTACAATGCAACT
ACAGGTGAATACGGTGATATGTTAGAGATGGGTATTATTGACCCGACTAAAGTAGCCCGTAGCGCACTGCAGTTTGCTGC
ATCGGTAGCTGCTCTTATGATCACGACTGAATGTATGATCACCGATCGCCCTGTTGCGGCTTCAGCAGCAGCGCCTGATA
TGGGCGGTATGGGTGGAATGGGCGGTATGATGTGA

Upstream 100 bases:

>100_bases
GTGAAAACGATATCCTTGCCGTCGTTGAATAACGCCTATCTGCTTCTCTAGCGTTCAACAAGTAAGACTCTCAATATTAA
AGATTTAAAGGAATATAATA

Downstream 100 bases:

>100_bases
TCATCCTTTGATTATTTTATAGGAACTCATCACGTTTCATTAAGCCCGTAAAGCCATGCTTTACGGGCTTTTTTTTGTAT
TAATATCGGCATAAGCTGGT

Product: chaperonin Cpn60, GroEL, large subunit of GroESL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQT
NDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEI
IAQAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAK
RVVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM

Sequences:

>Translated_544_residues
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQT
NDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEI
IAQAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAK
RVVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM
>Mature_543_residues
SKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQTN
DAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEII
AQAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVAK
ASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAKR
VVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHA
TRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNATT
GEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=524, Percent_Identity=51.7175572519084, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=524, Percent_Identity=51.7175572519084, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=81.0707456978968, Blast_Score=862, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=526, Percent_Identity=51.5209125475285, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=53.3653846153846, Blast_Score=212, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.8167938931298, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322524, Length=163, Percent_Identity=28.2208588957055, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=524, Percent_Identity=51.9083969465649, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=524, Percent_Identity=51.9083969465649, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=49.9047619047619, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=49.9047619047619, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=49.9047619047619, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=43.7858508604207, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24584129, Length=548, Percent_Identity=37.2262773722628, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI19921262, Length=548, Percent_Identity=37.2262773722628, Blast_Score=349, Evalue=3e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PSYIN (A1ST72)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942286.1
- ProteinModelPortal:   A1ST72
- SMR:   A1ST72
- STRING:   A1ST72
- GeneID:   4626609
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0844
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   CELENAY
- PhylomeDB:   A1ST72
- ProtClustDB:   CLSK2558375
- BioCyc:   PING357804:PING_0844-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57424; Mature: 57293

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHCC
LEDKFENMGAQMVKDVASQTNDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEIIAQAMQKVGNQGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHH
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
SEEIGLDMEKVQLEDLGQAKRVVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYD
HHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
KEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGM
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
SKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHCC
LEDKFENMGAQMVKDVASQTNDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEIIAQAMQKVGNQGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHH
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
SEEIGLDMEKVQLEDLGQAKRVVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYD
HHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
KEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGM
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA