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The map label for this gene is folP-A [H]

Identifier: 119944574

GI number: 119944574

Start: 1015169

End: 1016002

Strand: Direct

Name: folP-A [H]

Synonym: Ping_0812

Alternate gene names: 119944574

Gene position: 1015169-1016002 (Clockwise)

Preceding gene: 119944573

Following gene: 119944575

Centisome position: 22.26

GC content: 42.45

Gene sequence:

>834_bases
ATGCAGTTAATAAGCGGCAGTAAAATACTTGATTTGAGCGAGCCTAAGGTAATGGGGATTTTAAATGTCACGCCTGATTC
TTTCTCCGATGGGGGGCGTTTTTCGAATATCGATAATGCCCTTAAGCAAGCTCAAAAAATGCTTGAGCAGGGGGCCAGTA
TTTTGGATATCGGTGGTGAGTCGACTCGCCCGGGGGCAATCGATGTGAGCGAACAGCAGGAGCTGGATCGTGTTATACCG
GTCATTGAACAAATAAATCAAGAGTTTGATTGTTGGATTTCTATTGATACAAGCAAAGCTAATGTGATGCAGGCAGCCGT
TAATGCGGGTGCAGACTTGATTAATGATGTTAGGGCACTACGCGAAGATAATGCGCTGGATGTTGCGGTTAACGCTAATG
TGCCAGTGTGTCTGATGCATATGCAGGGTCAGCCAAGAAGCATGCAAAGCGCCCCTGAATATGAAAATGTCATTGAAGAG
GTAAAAACTTTTTTGTTACAACGTGCTGAAATTTGTATTAATGCCGGCATCAAAAAAGAAAATATTATTTTAGATTTGGG
TTTTGGTTTTGGTAAGCAACTCAACGATAATTATGAGTTACTGGCTGCCACGGATCAATTTGTTAAATTAAATTATCCTA
TTTTGACCGGCCTCTCTAGAAAGTCCATGTTTGGGCAATTGCTGAATCGTGATGTAACTCACCGCCTCGCCGGCAGTCTT
GCCGGAGCTTTAATCGCTCTGCAGCAAGGGTCGCAAATTATTCGTGTGCATGATGTTGCAGAAACCGCCGATGTTATTAA
AGTATTACAAACCGTAAACGCTTTTAAAAAATAA

Upstream 100 bases:

>100_bases
GATAAATAATAATCAAAGCTGATTTATTTTATAAATTATCAATAAAAAACCTAAGCTTGCTTAGGTTTTTTTATTGGTAT
GATGAGTATAACGGAGCATT

Downstream 100 bases:

>100_bases
ACTTGTTCAGAAATAAACCCGTTAAGAAAATGAGATAATAATGAAAAAAAAATATTTTGGTACCGATGGCATTCGCGGCA
AAGTAGGTGCTTCTTTAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MQLISGSKILDLSEPKVMGILNVTPDSFSDGGRFSNIDNALKQAQKMLEQGASILDIGGESTRPGAIDVSEQQELDRVIP
VIEQINQEFDCWISIDTSKANVMQAAVNAGADLINDVRALREDNALDVAVNANVPVCLMHMQGQPRSMQSAPEYENVIEE
VKTFLLQRAEICINAGIKKENIILDLGFGFGKQLNDNYELLAATDQFVKLNYPILTGLSRKSMFGQLLNRDVTHRLAGSL
AGALIALQQGSQIIRVHDVAETADVIKVLQTVNAFKK

Sequences:

>Translated_277_residues
MQLISGSKILDLSEPKVMGILNVTPDSFSDGGRFSNIDNALKQAQKMLEQGASILDIGGESTRPGAIDVSEQQELDRVIP
VIEQINQEFDCWISIDTSKANVMQAAVNAGADLINDVRALREDNALDVAVNANVPVCLMHMQGQPRSMQSAPEYENVIEE
VKTFLLQRAEICINAGIKKENIILDLGFGFGKQLNDNYELLAATDQFVKLNYPILTGLSRKSMFGQLLNRDVTHRLAGSL
AGALIALQQGSQIIRVHDVAETADVIKVLQTVNAFKK
>Mature_277_residues
MQLISGSKILDLSEPKVMGILNVTPDSFSDGGRFSNIDNALKQAQKMLEQGASILDIGGESTRPGAIDVSEQQELDRVIP
VIEQINQEFDCWISIDTSKANVMQAAVNAGADLINDVRALREDNALDVAVNANVPVCLMHMQGQPRSMQSAPEYENVIEE
VKTFLLQRAEICINAGIKKENIILDLGFGFGKQLNDNYELLAATDQFVKLNYPILTGLSRKSMFGQLLNRDVTHRLAGSL
AGALIALQQGSQIIRVHDVAETADVIKVLQTVNAFKK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=277, Percent_Identity=53.0685920577617, Blast_Score=313, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=29.874213836478, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30278; Mature: 30278

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLISGSKILDLSEPKVMGILNVTPDSFSDGGRFSNIDNALKQAQKMLEQGASILDIGGE
CCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAIDVSEQQELDRVIPVIEQINQEFDCWISIDTSKANVMQAAVNAGADLINDVRAL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHH
REDNALDVAVNANVPVCLMHMQGQPRSMQSAPEYENVIEEVKTFLLQRAEICINAGIKKE
HCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIILDLGFGFGKQLNDNYELLAATDQFVKLNYPILTGLSRKSMFGQLLNRDVTHRLAGSL
CEEEEECCCCCCCCCCCCEEEEECCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGALIALQQGSQIIRVHDVAETADVIKVLQTVNAFKK
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLISGSKILDLSEPKVMGILNVTPDSFSDGGRFSNIDNALKQAQKMLEQGASILDIGGE
CCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAIDVSEQQELDRVIPVIEQINQEFDCWISIDTSKANVMQAAVNAGADLINDVRAL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHH
REDNALDVAVNANVPVCLMHMQGQPRSMQSAPEYENVIEEVKTFLLQRAEICINAGIKKE
HCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIILDLGFGFGKQLNDNYELLAATDQFVKLNYPILTGLSRKSMFGQLLNRDVTHRLAGSL
CEEEEECCCCCCCCCCCCEEEEECCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGALIALQQGSQIIRVHDVAETADVIKVLQTVNAFKK
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]