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The map label for this gene is ispD [H]

Identifier: 119944444

GI number: 119944444

Start: 860376

End: 861065

Strand: Direct

Name: ispD [H]

Synonym: Ping_0672

Alternate gene names: 119944444

Gene position: 860376-861065 (Clockwise)

Preceding gene: 119944443

Following gene: 119944445

Centisome position: 18.87

GC content: 43.19

Gene sequence:

>690_bases
ATGAGTCGATTAAATTTAAATGCGGTGATTGCCGCTGCTGGGATAGGTCAACGTGTTGGGGCCCATATCCCTAAACAATA
CCTGCCCCTGTTAGGTAAGACAATTATCGAACACAGCATCGCGCCATTTTTGAACCACCCTGATATAAAAAAGGTCATTG
TTGTCATTGCAGAGAATGATTGTTGGTTTGCACAGCTGCCGCTTGCTGAAAATTCTAAGATAAAAGTGGTTATTGGCGGA
AAAGAGCGTGTTGATTCTGTGTTATGTGCATTAAAAGTGCTGCCGAGCGAGGAATATGTTCTGGTGCATGACGCGGCACG
CCCCTGTATTAAAAGCACCGATATCAATAAACTTATCAATACGGCAGTGCAGTCAAAACATGGCGCAATTCTTGGGACTC
GGGTACGCGATACCATGAAACGCAGTGATTTCGATGGTCAGATCACTCAGACTGTCAGTAGGACAAATCTTTGGCATGCT
TTGACACCGCAGATGTTTGAAAATAAAGTATTAATTAATGCGATAGAAAGCGCCGAATTTCCAGAGCAGATCACCGATGA
GGCATCGGCAATGGAAATGGCAGGATTACCGGTTGCCATCATTGAAGGGCGTAGTGATAATTTAAAAGTGACTCGATCTG
AAGATTTAACACTCGCCGAATTATATTTATCATCACCAACAAGCAAATAA

Upstream 100 bases:

>100_bases
AGAGGGGACGGACGCAATAGAAGAACGTGCGCGCAATGAGTTAGGTTTAGTTAAAGAGGGTGAAACTTTTTTCCGTATTG
TGCCAAAAGAAGATTAATGA

Downstream 100 bases:

>100_bases
TAAAGGGTAACTTATGATCCGTATCGGACATGGCTTTGATGTGCACAAATTTGGTGGGCAAGGACCTATCACTATTGCCG
GCGTGAAAATCCCTTATCAT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSRLNLNAVIAAAGIGQRVGAHIPKQYLPLLGKTIIEHSIAPFLNHPDIKKVIVVIAENDCWFAQLPLAENSKIKVVIGG
KERVDSVLCALKVLPSEEYVLVHDAARPCIKSTDINKLINTAVQSKHGAILGTRVRDTMKRSDFDGQITQTVSRTNLWHA
LTPQMFENKVLINAIESAEFPEQITDEASAMEMAGLPVAIIEGRSDNLKVTRSEDLTLAELYLSSPTSK

Sequences:

>Translated_229_residues
MSRLNLNAVIAAAGIGQRVGAHIPKQYLPLLGKTIIEHSIAPFLNHPDIKKVIVVIAENDCWFAQLPLAENSKIKVVIGG
KERVDSVLCALKVLPSEEYVLVHDAARPCIKSTDINKLINTAVQSKHGAILGTRVRDTMKRSDFDGQITQTVSRTNLWHA
LTPQMFENKVLINAIESAEFPEQITDEASAMEMAGLPVAIIEGRSDNLKVTRSEDLTLAELYLSSPTSK
>Mature_228_residues
SRLNLNAVIAAAGIGQRVGAHIPKQYLPLLGKTIIEHSIAPFLNHPDIKKVIVVIAENDCWFAQLPLAENSKIKVVIGGK
ERVDSVLCALKVLPSEEYVLVHDAARPCIKSTDINKLINTAVQSKHGAILGTRVRDTMKRSDFDGQITQTVSRTNLWHAL
TPQMFENKVLINAIESAEFPEQITDEASAMEMAGLPVAIIEGRSDNLKVTRSEDLTLAELYLSSPTSK

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=228, Percent_Identity=26.7543859649123, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1789104, Length=225, Percent_Identity=48.4444444444444, Blast_Score=214, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25102; Mature: 24971

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLNLNAVIAAAGIGQRVGAHIPKQYLPLLGKTIIEHSIAPFLNHPDIKKVIVVIAEND
CCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
CWFAQLPLAENSKIKVVIGGKERVDSVLCALKVLPSEEYVLVHDAARPCIKSTDINKLIN
CEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
TAVQSKHGAILGTRVRDTMKRSDFDGQITQTVSRTNLWHALTPQMFENKVLINAIESAEF
HHHHHCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCHHHHHCCCEEEHHHCCCC
PEQITDEASAMEMAGLPVAIIEGRSDNLKVTRSEDLTLAELYLSSPTSK
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SRLNLNAVIAAAGIGQRVGAHIPKQYLPLLGKTIIEHSIAPFLNHPDIKKVIVVIAEND
CCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
CWFAQLPLAENSKIKVVIGGKERVDSVLCALKVLPSEEYVLVHDAARPCIKSTDINKLIN
CEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
TAVQSKHGAILGTRVRDTMKRSDFDGQITQTVSRTNLWHALTPQMFENKVLINAIESAEF
HHHHHCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCHHHHHCCCEEEHHHCCCC
PEQITDEASAMEMAGLPVAIIEGRSDNLKVTRSEDLTLAELYLSSPTSK
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA