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The map label for this gene is pyrG

Identifier: 119944440

GI number: 119944440

Start: 856067

End: 857704

Strand: Direct

Name: pyrG

Synonym: Ping_0668

Alternate gene names: 119944440

Gene position: 856067-857704 (Clockwise)

Preceding gene: 119944439

Following gene: 119944441

Centisome position: 18.78

GC content: 43.04

Gene sequence:

>1638_bases
ATGACGACAAAATATATTTTCGTAACGGGTGGTGTTGTTTCATCACTCGGTAAAGGCATTGCAGCAGGTTCACTGGCTGC
TATTCTAGAAGCACGTGGTCTGGATGTCACCATTCTGAAACTAGATCCTTATATTAACGTAGACCCTGGCACCATGAGTC
CAATACAACATGGTGAAGTTTTTGTAACCGATGACGGTGCAGAAACAGATCTTGATTTAGGGCATTATGAGCGTTATATC
CGCACCAGAATGACCGCCCGTAATAACTTTACAACGGGTCGTGTTTATTCTGAAGTGATGGCTAAAGAGCGTCGTGGTGA
TTACCTTGGTGCAACCATCCAGGTTATTCCACATATTACTAACGAGATTCAAGAACGTATTGTTGCTGGTGGTAAAGGCC
ATGATATTGCGATCGTTGAACTCGGTGGCACGGTAGGTGATATTGAATCACAGCCCTTTTTGGAAGCGATTCGTCAGCTG
GGGCTAAAAGTCGGGCGTGACAGTGTTATCTACATGCACCTGACATTACTGCCTTACTTAAAAACCGCCGGTGAAGTTAA
AACCAAACCCACACAGCATTCGGTTAAAGAGTTGCGCAGTTTAGGTATTCAGCCAGATATTTTAGTCTGCCGCTCTGAAG
TGAATATTCCCATTAACGAACGTGTGAAGATCGCCTTATTCTGTAATGTCACCGAAAAATCGGTGATTTTATTACGCGAT
GTAGATTCTATCTATAAAATTCCAGCCTTGTTAAAAGCGCAGGGTCTTGATGAGATTTGTGTCAAACGTTTTGGTCTTGA
CTGCCCCGAAGCTGACTTAAGCGAATGGGCGCAAGTCGTTTCTGAAGAAGCGAACACCTCAAATGAAGTTATCATTGGCA
TGGTAGGTAAATACACTGAACTGCCAGATGCCTATAAATCTGTTAATGAAGCGCTTAAACATGGCGGGCTTAAAAATGCG
GCATCGGTCAAAATAAAATACATCGACTCGCAGGATGTTGAAGTGAGAGGCGTTTCTATTTTAGAAGGCGTTGATGCGAT
TTTAGTGCCGGGCGGTTTTGGTGAACGCGGTATTGAAGGTAAAATCCTCGCGGCTCAATATGCACGCGTAAATAAAATAC
CTTATTTAGGTATCTGTTTAGGGATGCAGGTTGCGATCATTGAGTTTGCACGCAATGTCGCTGGCCTTAAAAATGCCCAT
TCAACGGAATTTGAGGCTAACTGTGACCAACCTGTTGTTGGCTTGATCACTGAGTGGCTTGATAAAACCGGTGAAGTTGA
ACAGCGCACCGAAAATTCGGATTTAGGGGGCACGATGCGGGTAGGTGCACAGCTTTGCCACCTTAAAAAAGGTTCTAAAG
TGTTTGATATGTACGGCACAAAAGAGATATTTGAACGCCATCGTCATCGTTATGAGGTAAATAATAATTTATTACCTATT
TTAGAGAAAGCGGGGCTAGTGGTCACCGGTTTATCTGAAGATAAAAAATTAGTCGAAATTATTGAAATCCCAAATCATCC
CTGGTTCGTTGCTTCTCAATTCCATCCGGAATTCACCTCGACACCAAGAGATGGACACCCTTTATTTAAAGGTTTCATAA
AATCTGCGATAGATCATCAACAGGGCCGATTTGAATAG

Upstream 100 bases:

>100_bases
ATTAACCTCAGTGATTTCGTAAGCTGATGGTTTTTTGCGTTTTTATTTTTACAATTGAAGCTGAGTTTATTTTTCCCATT
CCTAAATTTTCAGGGTTACT

Downstream 100 bases:

>100_bases
TTTTTGTTGACCAGATCACTTTTTTTTGTTAAAAAATAACGCATTAAAGTGATCTGGAATTATATAACCCATTTTTAAAC
TTATTTTTAATACAACTAAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEVFVTDDGAETDLDLGHYERYI
RTRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHITNEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQL
GLKVGRDSVIYMHLTLLPYLKTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRD
VDSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTELPDAYKSVNEALKHGGLKNA
ASVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEGKILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAH
STEFEANCDQPVVGLITEWLDKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPI
LEKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQQGRFE

Sequences:

>Translated_545_residues
MTTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEVFVTDDGAETDLDLGHYERYI
RTRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHITNEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQL
GLKVGRDSVIYMHLTLLPYLKTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRD
VDSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTELPDAYKSVNEALKHGGLKNA
ASVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEGKILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAH
STEFEANCDQPVVGLITEWLDKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPI
LEKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQQGRFE
>Mature_544_residues
TTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEVFVTDDGAETDLDLGHYERYIR
TRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHITNEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQLG
LKVGRDSVIYMHLTLLPYLKTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRDV
DSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTELPDAYKSVNEALKHGGLKNAA
SVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEGKILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAHS
TEFEANCDQPVVGLITEWLDKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPIL
EKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQQGRFE

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=558, Percent_Identity=44.6236559139785, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=557, Percent_Identity=45.2423698384201, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI28559083, Length=557, Percent_Identity=45.2423698384201, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI221316689, Length=557, Percent_Identity=45.2423698384201, Blast_Score=466, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=73.3826247689464, Blast_Score=814, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=618, Percent_Identity=38.1877022653722, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=572, Percent_Identity=43.006993006993, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=41.4762741652021, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=45.0805008944544, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.3663366336634, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_PSYIN (A1SSQ6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942120.1
- ProteinModelPortal:   A1SSQ6
- SMR:   A1SSQ6
- STRING:   A1SSQ6
- GeneID:   4626905
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0668
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   A1SSQ6
- ProtClustDB:   PRK05380
- BioCyc:   PING357804:PING_0668-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60031; Mature: 59900

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 379-379 ACT_SITE 515-515 ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYIRTRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQLGLKVGRDSVIYMHLTLLPYL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
KTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRD
HCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEC
VDSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
LPDAYKSVNEALKHGGLKNAASVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEG
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCHHHCCCCEEEECCCCCCCCCCC
KILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAHSTEFEANCDQPVVGLITEWL
CEEEHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
DKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPI
HCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHEECCCCCHHH
LEKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQ
HHHCCEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCC
QGRFE
CCCCC
>Mature Secondary Structure 
TTKYIFVTGGVVSSLGKGIAAGSLAAILEARGLDVTILKLDPYINVDPGTMSPIQHGEV
CEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYIRTRMTARNNFTTGRVYSEVMAKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NEIQERIVAGGKGHDIAIVELGGTVGDIESQPFLEAIRQLGLKVGRDSVIYMHLTLLPYL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
KTAGEVKTKPTQHSVKELRSLGIQPDILVCRSEVNIPINERVKIALFCNVTEKSVILLRD
HCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEC
VDSIYKIPALLKAQGLDEICVKRFGLDCPEADLSEWAQVVSEEANTSNEVIIGMVGKYTE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
LPDAYKSVNEALKHGGLKNAASVKIKYIDSQDVEVRGVSILEGVDAILVPGGFGERGIEG
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCHHHCCCCEEEECCCCCCCCCCC
KILAAQYARVNKIPYLGICLGMQVAIIEFARNVAGLKNAHSTEFEANCDQPVVGLITEWL
CEEEHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
DKTGEVEQRTENSDLGGTMRVGAQLCHLKKGSKVFDMYGTKEIFERHRHRYEVNNNLLPI
HCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHEECCCCCHHH
LEKAGLVVTGLSEDKKLVEIIEIPNHPWFVASQFHPEFTSTPRDGHPLFKGFIKSAIDHQ
HHHCCEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCC
QGRFE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA