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The map label for this gene is hlyD [H]

Identifier: 119944248

GI number: 119944248

Start: 595092

End: 596171

Strand: Direct

Name: hlyD [H]

Synonym: Ping_0472

Alternate gene names: 119944248

Gene position: 595092-596171 (Clockwise)

Preceding gene: 119944247

Following gene: 119944249

Centisome position: 13.05

GC content: 45.46

Gene sequence:

>1080_bases
ATGAACAAACAGATTCTGCGCGCAGCATTAATCACTATCATCACTATTGGTACAAGTTATCACTCACTGTTATCAGCACA
GGAAAGAGAAATGCCCGCTGTTTCTGTTTATACGGAGAGCGTGGCCTATCATCAGGTAGCACAGTCACTTTCTTTGATTG
GCAAGTTGCAGTCAGATCAGTCTGTGAATGTCGCCACTGAAGTCGACGGTAAAGTCAAATCCATTAATGTCCAGGCTAAC
CAGCAGGTCAAAACTGGGCAGCTGTTATTCCAATTGGACGATACCAAAGCACAGGCAGCGATGCTGGAAGCGCAGGCTTA
TTTTTTTGATGAACAGCGTAAATTACGCGAATTTACAAAGTTAGTAAAAAGCAATGCCATTACTCAGACGGCAGTAGAAG
GGCAGATCGCAAGCGTCGATATTGCCCGGGCACGTTTAAAGGCTGCTCAAGCAGAAGTGGATCGCCACGCTTTAAGCGCA
CCTTTTGCCGGCACGATTGGGCTGATTGATTTTAGTTTAGGTAAGATGGTGGGAACGGGCAGTGAGCTGATGACCCTTGA
TAATCTTACTCAAATGACGCTGGATCTGCAGGTGCCGGAACGTTATTTATCCATGCTCAGCAAAGGGATGCCCGTGAGTG
CAACTAGCCGCTCGTGGCCAGAGACGATATTTAACGGGCAGTTGACGGCAACAAATTCGCGTATTAACCCGGATACCCTT
AACCTGCGTGTACGGGTCTTATTTAATAATCCGGATAATAAATTAAAACCAGGCATGATGATGTCCGCCAAAATAGTTTT
CCCCGCCATTAATGCCCCTGTTATCCCGGTGCAGGCGTTAGAGTACTCGGGCACTAAACGTTATGTTTATATCGTTAATA
AGCAGGGCATGGCAAGTCGTCAGGAAGTTATTTTAGGGGCACGTATTAAAAACCAGATACTGATTGAAAAGGGTGTCAAG
ATTGGAGACAAAATTGTGGTGCAGGGGTTGGTTAATATGCGTGACGGGTTAAAGGTAGAAGATCTTTCCAGCATAGAAAA
ACCCGATGAAAGCAGCAAAAAAATGCAGGAGAGCAAATAA

Upstream 100 bases:

>100_bases
ATGGCAAAAAAAACTTGGCAATCATCTCTGCAATCATAATAATAGAACTTCCGGCAAACTAGCCATAGAATGATCAAACA
GTTAAGGGATCATAAAAGAA

Downstream 100 bases:

>100_bases
TGAGGCTTTCCTATACTGAGGTTAAAAATGCGGTTAAACGTCCTGTTGTAGCGATTGTATTAAGTTTATTACCTTGTGTT
TTTGGTGTTGTCTCTTTCGA

Product: secretion protein HlyD

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNKQILRAALITIITIGTSYHSLLSAQEREMPAVSVYTESVAYHQVAQSLSLIGKLQSDQSVNVATEVDGKVKSINVQAN
QQVKTGQLLFQLDDTKAQAAMLEAQAYFFDEQRKLREFTKLVKSNAITQTAVEGQIASVDIARARLKAAQAEVDRHALSA
PFAGTIGLIDFSLGKMVGTGSELMTLDNLTQMTLDLQVPERYLSMLSKGMPVSATSRSWPETIFNGQLTATNSRINPDTL
NLRVRVLFNNPDNKLKPGMMMSAKIVFPAINAPVIPVQALEYSGTKRYVYIVNKQGMASRQEVILGARIKNQILIEKGVK
IGDKIVVQGLVNMRDGLKVEDLSSIEKPDESSKKMQESK

Sequences:

>Translated_359_residues
MNKQILRAALITIITIGTSYHSLLSAQEREMPAVSVYTESVAYHQVAQSLSLIGKLQSDQSVNVATEVDGKVKSINVQAN
QQVKTGQLLFQLDDTKAQAAMLEAQAYFFDEQRKLREFTKLVKSNAITQTAVEGQIASVDIARARLKAAQAEVDRHALSA
PFAGTIGLIDFSLGKMVGTGSELMTLDNLTQMTLDLQVPERYLSMLSKGMPVSATSRSWPETIFNGQLTATNSRINPDTL
NLRVRVLFNNPDNKLKPGMMMSAKIVFPAINAPVIPVQALEYSGTKRYVYIVNKQGMASRQEVILGARIKNQILIEKGVK
IGDKIVVQGLVNMRDGLKVEDLSSIEKPDESSKKMQESK
>Mature_359_residues
MNKQILRAALITIITIGTSYHSLLSAQEREMPAVSVYTESVAYHQVAQSLSLIGKLQSDQSVNVATEVDGKVKSINVQAN
QQVKTGQLLFQLDDTKAQAAMLEAQAYFFDEQRKLREFTKLVKSNAITQTAVEGQIASVDIARARLKAAQAEVDRHALSA
PFAGTIGLIDFSLGKMVGTGSELMTLDNLTQMTLDLQVPERYLSMLSKGMPVSATSRSWPETIFNGQLTATNSRINPDTL
NLRVRVLFNNPDNKLKPGMMMSAKIVFPAINAPVIPVQALEYSGTKRYVYIVNKQGMASRQEVILGARIKNQILIEKGVK
IGDKIVVQGLVNMRDGLKVEDLSSIEKPDESSKKMQESK

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=356, Percent_Identity=25.2808988764045, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87081796, Length=355, Percent_Identity=26.4788732394366, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789665, Length=365, Percent_Identity=24.3835616438356, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786668, Length=354, Percent_Identity=22.316384180791, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39473; Mature: 39473

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQILRAALITIITIGTSYHSLLSAQEREMPAVSVYTESVAYHQVAQSLSLIGKLQSDQ
CCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCC
SVNVATEVDGKVKSINVQANQQVKTGQLLFQLDDTKAQAAMLEAQAYFFDEQRKLREFTK
CCEEEEECCCEEEEEEEECCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVKSNAITQTAVEGQIASVDIARARLKAAQAEVDRHALSAPFAGTIGLIDFSLGKMVGTG
HHHHCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHCCC
SELMTLDNLTQMTLDLQVPERYLSMLSKGMPVSATSRSWPETIFNGQLTATNSRINPDTL
CHHEECCCCEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCEE
NLRVRVLFNNPDNKLKPGMMMSAKIVFPAINAPVIPVQALEYSGTKRYVYIVNKQGMASR
EEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCH
QEVILGARIKNQILIEKGVKIGDKIVVQGLVNMRDGLKVEDLSSIEKPDESSKKMQESK
HHHEEHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MNKQILRAALITIITIGTSYHSLLSAQEREMPAVSVYTESVAYHQVAQSLSLIGKLQSDQ
CCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCC
SVNVATEVDGKVKSINVQANQQVKTGQLLFQLDDTKAQAAMLEAQAYFFDEQRKLREFTK
CCEEEEECCCEEEEEEEECCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVKSNAITQTAVEGQIASVDIARARLKAAQAEVDRHALSAPFAGTIGLIDFSLGKMVGTG
HHHHCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHCCC
SELMTLDNLTQMTLDLQVPERYLSMLSKGMPVSATSRSWPETIFNGQLTATNSRINPDTL
CHHEECCCCEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCEE
NLRVRVLFNNPDNKLKPGMMMSAKIVFPAINAPVIPVQALEYSGTKRYVYIVNKQGMASR
EEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCH
QEVILGARIKNQILIEKGVKIGDKIVVQGLVNMRDGLKVEDLSSIEKPDESSKKMQESK
HHHEEHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA