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The map label for this gene is livH [H]

Identifier: 119900020

GI number: 119900020

Start: 4087402

End: 4088334

Strand: Direct

Name: livH [H]

Synonym: azo3731

Alternate gene names: 119900020

Gene position: 4087402-4088334 (Clockwise)

Preceding gene: 119900019

Following gene: 119900021

Centisome position: 93.4

GC content: 65.81

Gene sequence:

>933_bases
ATGGAAACCCTCATCCAGCAGACGATCAACGGCCTGGTGATCGGCAGCGTGTACGCGCTGATCGCACTCGGCTACACCAT
GGTTTACGGCATTCTCGGCCTGATCAACTTCGCCCACGGCGACGTACTGATGGTGGGCGCGATGACCGCGCTGCAGACCA
TGCTGTTCCTGATGGGGGTGGCGCCCGGCATGTCGCCGCTGGTCATGCTGACGATCGCGCTGCTGGTGGCGATTCCGGTG
TCAATGCTGATCGGCTTCACGATGGAGCGGCTGGCCTACCGACGCTTGCGCAACGCGCCGCGGCTGGCGCCGCTGATCAC
CGCGATCGGCATGTCCTTCCTGCTGCAGACGATCGCGATGATCATCTGGGGCCGCAACTACCACACCTTTCCGCAACTCA
TCTCGACCACGCCGCTGCAGCCGGTCGAAGGCGTGTTCGTCACCCCGGTGCAGATCGTCATCGTGATCGTGTCGGCGCTG
CTGATGATCGGCCTGACGCTGCTGGTCAGCCGCACCCGCATCGGCCGCGCGATGCGCGCCACCGCCGAAAACCACCGCAC
CGCCAGCCTGATGGGCGTGGATACCAACGCCGTCATCGCCTTCACCTTCGTCATTGGCGCCGGGCTGGCCGCGGTGGCGG
GCGTGATGTACGCCAGCAACTACGGCATCGCCCACTACGGCATGGGCTTCATGCCGGGGCTCAAGGCCTTCACCGCCGCG
GTGCTCGGCGGCATCGGCAACCTCGGCGGCGCGATGGTGGGCGGCGTGGTGCTCGGCCTGGTCGAATCCTTCGGCGCCGG
CTACATCGAGCACCTCACCTTCGGTTTCCTCAACTCGTCCTACCAGGACATCTTCGCCTTCCTGATCCTCGGCCTGGTGC
TGATCTTCCGGCCCACCGGGCTGCTCGGCGAACGCGTGTCCGACCGCGCGTAA

Upstream 100 bases:

>100_bases
GGCGCGCGGCCACACGCCGCGCCCCTCGCGGCGCCGGCACCGATGCCGGCGCCGCCTGCTCCACCCGCACTTCAAGCTAT
CCGCCGCGCGCAAGGGCCCG

Downstream 100 bases:

>100_bases
GGGGAAAGAACCATGAACGAACTCGCCGCCGCCATTCCCTGGCTGGGCAAACGCAACCCGCTCGCCGCGCGCTGGCTGAT
CCTGATCCTCGCCATCGCCG

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
METLIQQTINGLVIGSVYALIALGYTMVYGILGLINFAHGDVLMVGAMTALQTMLFLMGVAPGMSPLVMLTIALLVAIPV
SMLIGFTMERLAYRRLRNAPRLAPLITAIGMSFLLQTIAMIIWGRNYHTFPQLISTTPLQPVEGVFVTPVQIVIVIVSAL
LMIGLTLLVSRTRIGRAMRATAENHRTASLMGVDTNAVIAFTFVIGAGLAAVAGVMYASNYGIAHYGMGFMPGLKAFTAA
VLGGIGNLGGAMVGGVVLGLVESFGAGYIEHLTFGFLNSSYQDIFAFLILGLVLIFRPTGLLGERVSDRA

Sequences:

>Translated_310_residues
METLIQQTINGLVIGSVYALIALGYTMVYGILGLINFAHGDVLMVGAMTALQTMLFLMGVAPGMSPLVMLTIALLVAIPV
SMLIGFTMERLAYRRLRNAPRLAPLITAIGMSFLLQTIAMIIWGRNYHTFPQLISTTPLQPVEGVFVTPVQIVIVIVSAL
LMIGLTLLVSRTRIGRAMRATAENHRTASLMGVDTNAVIAFTFVIGAGLAAVAGVMYASNYGIAHYGMGFMPGLKAFTAA
VLGGIGNLGGAMVGGVVLGLVESFGAGYIEHLTFGFLNSSYQDIFAFLILGLVLIFRPTGLLGERVSDRA
>Mature_310_residues
METLIQQTINGLVIGSVYALIALGYTMVYGILGLINFAHGDVLMVGAMTALQTMLFLMGVAPGMSPLVMLTIALLVAIPV
SMLIGFTMERLAYRRLRNAPRLAPLITAIGMSFLLQTIAMIIWGRNYHTFPQLISTTPLQPVEGVFVTPVQIVIVIVSAL
LMIGLTLLVSRTRIGRAMRATAENHRTASLMGVDTNAVIAFTFVIGAGLAAVAGVMYASNYGIAHYGMGFMPGLKAFTAA
VLGGIGNLGGAMVGGVVLGLVESFGAGYIEHLTFGFLNSSYQDIFAFLILGLVLIFRPTGLLGERVSDRA

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=311, Percent_Identity=43.7299035369775, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32891; Mature: 32891

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLIQQTINGLVIGSVYALIALGYTMVYGILGLINFAHGDVLMVGAMTALQTMLFLMGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
APGMSPLVMLTIALLVAIPVSMLIGFTMERLAYRRLRNAPRLAPLITAIGMSFLLQTIAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIWGRNYHTFPQLISTTPLQPVEGVFVTPVQIVIVIVSALLMIGLTLLVSRTRIGRAMRA
HHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAENHRTASLMGVDTNAVIAFTFVIGAGLAAVAGVMYASNYGIAHYGMGFMPGLKAFTAA
HHHCCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHH
VLGGIGNLGGAMVGGVVLGLVESFGAGYIEHLTFGFLNSSYQDIFAFLILGLVLIFRPTG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LLGERVSDRA
HHHHHHCCCC
>Mature Secondary Structure
METLIQQTINGLVIGSVYALIALGYTMVYGILGLINFAHGDVLMVGAMTALQTMLFLMGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
APGMSPLVMLTIALLVAIPVSMLIGFTMERLAYRRLRNAPRLAPLITAIGMSFLLQTIAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IIWGRNYHTFPQLISTTPLQPVEGVFVTPVQIVIVIVSALLMIGLTLLVSRTRIGRAMRA
HHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAENHRTASLMGVDTNAVIAFTFVIGAGLAAVAGVMYASNYGIAHYGMGFMPGLKAFTAA
HHHCCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHH
VLGGIGNLGGAMVGGVVLGLVESFGAGYIEHLTFGFLNSSYQDIFAFLILGLVLIFRPTG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LLGERVSDRA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043; 2509433 [H]