Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 119899959

GI number: 119899959

Start: 4030246

End: 4030803

Strand: Direct

Name: hpt [H]

Synonym: azo3670

Alternate gene names: 119899959

Gene position: 4030246-4030803 (Clockwise)

Preceding gene: 119899958

Following gene: 119899960

Centisome position: 92.1

GC content: 68.28

Gene sequence:

>558_bases
ATGCCGATGGACATGGCCGAAATCCTGCGCGCGCGCGAAGAGGCGGACTGCCTCGCGGATGCCGCGGCCGTCGAGGCCGC
ACTCGACCGCATGGCCGCCGCGATCACCGCCCGCATGGCGGACAGCAACCCTTTGATCTACACGGTGATGAACGGCGGCC
TGATCCTCGCCGGCCGCATCCTGCCGCGGCTGCCGTTTCCGCTCGAAGTCGCCTACCTGCACGCCACTCGCTACGGCCAC
GCGCTGCAGGGCACGCTACTCGACTGGCGGGTGCGGCCCACCCAGGACCTGCGCGGGCGCAGCGTGCTGGTGCTGGACGA
CATCCTCGACGAGGGCCACACGCTGCAGGCCATCATCGAACACCTGAAAGCCGAAGGCGCCCGCGAAGTCCTGTCGGCCG
TGCTGGTGCACAAGCTGCACGATCGCAAAGCCTACCCCGGCATGCGGGCCGACTTCACCGGGCTGGACATCGCCGACCGC
TTCCTGTTCGGTTGCGGCATGGACTACAAGGACTACTGGCGCAACGCGCCGGGCATCTACGCCGTCAAGGGACTCTGA

Upstream 100 bases:

>100_bases
GCCCTCCCCGGTGCGCGCGCCGTCCGGCCTCTCCCACGGGGCCGTGGTCTAGAATTGACAGTATTTCCCTTCCGACAAAC
ACCCGCCGGAGCTGCACCCG

Downstream 100 bases:

>100_bases
GGAGCACGCGATGCTGTACACCTTCAAATCCGACGCCGCCGCCGAGGTCCTGATGCTCGGCGACGCGGCCAGGAAACTGA
TCGCGATCCTGGGCAAGGAC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MPMDMAEILRAREEADCLADAAAVEAALDRMAAAITARMADSNPLIYTVMNGGLILAGRILPRLPFPLEVAYLHATRYGH
ALQGTLLDWRVRPTQDLRGRSVLVLDDILDEGHTLQAIIEHLKAEGAREVLSAVLVHKLHDRKAYPGMRADFTGLDIADR
FLFGCGMDYKDYWRNAPGIYAVKGL

Sequences:

>Translated_185_residues
MPMDMAEILRAREEADCLADAAAVEAALDRMAAAITARMADSNPLIYTVMNGGLILAGRILPRLPFPLEVAYLHATRYGH
ALQGTLLDWRVRPTQDLRGRSVLVLDDILDEGHTLQAIIEHLKAEGAREVLSAVLVHKLHDRKAYPGMRADFTGLDIADR
FLFGCGMDYKDYWRNAPGIYAVKGL
>Mature_184_residues
PMDMAEILRAREEADCLADAAAVEAALDRMAAAITARMADSNPLIYTVMNGGLILAGRILPRLPFPLEVAYLHATRYGHA
LQGTLLDWRVRPTQDLRGRSVLVLDDILDEGHTLQAIIEHLKAEGAREVLSAVLVHKLHDRKAYPGMRADFTGLDIADRF
LFGCGMDYKDYWRNAPGIYAVKGL

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=25.1428571428571, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20486; Mature: 20355

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMDMAEILRAREEADCLADAAAVEAALDRMAAAITARMADSNPLIYTVMNGGLILAGRI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECHH
LPRLPFPLEVAYLHATRYGHALQGTLLDWRVRPTQDLRGRSVLVLDDILDEGHTLQAIIE
HHCCCCCHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCCCEEEEEHHHHCCCCHHHHHHH
HLKAEGAREVLSAVLVHKLHDRKAYPGMRADFTGLDIADRFLFGCGMDYKDYWRNAPGIY
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCEE
AVKGL
EECCC
>Mature Secondary Structure 
PMDMAEILRAREEADCLADAAAVEAALDRMAAAITARMADSNPLIYTVMNGGLILAGRI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECHH
LPRLPFPLEVAYLHATRYGHALQGTLLDWRVRPTQDLRGRSVLVLDDILDEGHTLQAIIE
HHCCCCCHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCCCEEEEEHHHHCCCCHHHHHHH
HLKAEGAREVLSAVLVHKLHDRKAYPGMRADFTGLDIADRFLFGCGMDYKDYWRNAPGIY
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCEE
AVKGL
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]