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The map label for this gene is 119867172

Identifier: 119867172

GI number: 119867172

Start: 1209435

End: 1210322

Strand: Reverse

Name: 119867172

Synonym: Mkms_1121

Alternate gene names: NA

Gene position: 1210322-1209435 (Counterclockwise)

Preceding gene: 119867175

Following gene: 119867171

Centisome position: 21.1

GC content: 68.47

Gene sequence:

>888_bases
ATGACCACATCAGCCAACCAGGGAATCGTAGTGGGGGTCGACGGGTCACCGCAGGGCATGCGAGCCGTCACGTGGGCGGC
GCGCGAGGCCGCCGGCCGGGATGTGCCGCTGACGCTCGTCCACGTGCTGCCCGACACGGAAGTGCGGATGTGGCTTGACG
TTCCGCCGACGGACGAGTTCTGGCGCACGGTCGAGCACCAGAATCGTGAGATCCAGTCCGAGGCGGTCAAGACCGCCGAG
GCCGCGGTCGCCGGCACGGGTTCGCTCACCGTGCGCCAGCGCAGTGTGTCGGGCAACGCCGTACCCACGCTGGTCGACCT
GTCCAAGGACGCCGAGATGGTCGTGGTGGGCAGTCGCGGCCTCGGTGCGATCGGACAACGGATCCTGGGTTCGGTGAGCC
GGGGTCTGGTACACCACGCGCACTGTCCGGTCGCGGTGATTCACGACGACGAACCGGACGCGCCCGAGCGGGATCGGGCG
CCCGTGGTCGTCGGTATCGACGGCTCGCCGGCATCCGAACTGGCCACGGCGATCGCATTCGATCAGGCCTCGCGGCGAAA
GGTCGAACTGATCGCCGTCCACGCGTGGAGCGACCCGACGATCTACGCGTTCCCCAACGAGGAGTGGATGACCTTCAAAC
CGCAGGCCGACGAGGTGCTGGCAGAACGGTTGGCCGGCTGGGCGGACCGCTATCCCGATGTACCCGTGCAGCGTGTCGTG
GTGCGGGACAAAGCGGTGCACCAGCTGCTGGAGCAGTCCGAACACGCCCAACTCGTGGTGGTCGGCAGCCACGGTCGCGG
CGGATTCGCGGGAATGCTCCTGGGATCGGTCAGTTCCGCGGTGGCGCAGGCGGCCCGCGTACCGGTGATCGTGGCACGCC
AGTCGTGA

Upstream 100 bases:

>100_bases
TGGTCTTTGGTCCTCCCTCTGATGCAGACCAACGCCCCCAGCGCGGTGGGCCCCCAGGTCCTAATGTCAGGACTGGTCGA
GGGATCACCGAGGAGGCGAT

Downstream 100 bases:

>100_bases
CAATGGTGCGGTGGAACGCTTGAGAGCCCCCGCCACGGCGCGCCCGGCCGACGCCGAGCTTCTGGGCCCACCCGACCGTG
CACTGCACCATGCGTCGCTC

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTTSANQGIVVGVDGSPQGMRAVTWAAREAAGRDVPLTLVHVLPDTEVRMWLDVPPTDEFWRTVEHQNREIQSEAVKTAE
AAVAGTGSLTVRQRSVSGNAVPTLVDLSKDAEMVVVGSRGLGAIGQRILGSVSRGLVHHAHCPVAVIHDDEPDAPERDRA
PVVVGIDGSPASELATAIAFDQASRRKVELIAVHAWSDPTIYAFPNEEWMTFKPQADEVLAERLAGWADRYPDVPVQRVV
VRDKAVHQLLEQSEHAQLVVVGSHGRGGFAGMLLGSVSSAVAQAARVPVIVARQS

Sequences:

>Translated_295_residues
MTTSANQGIVVGVDGSPQGMRAVTWAAREAAGRDVPLTLVHVLPDTEVRMWLDVPPTDEFWRTVEHQNREIQSEAVKTAE
AAVAGTGSLTVRQRSVSGNAVPTLVDLSKDAEMVVVGSRGLGAIGQRILGSVSRGLVHHAHCPVAVIHDDEPDAPERDRA
PVVVGIDGSPASELATAIAFDQASRRKVELIAVHAWSDPTIYAFPNEEWMTFKPQADEVLAERLAGWADRYPDVPVQRVV
VRDKAVHQLLEQSEHAQLVVVGSHGRGGFAGMLLGSVSSAVAQAARVPVIVARQS
>Mature_294_residues
TTSANQGIVVGVDGSPQGMRAVTWAAREAAGRDVPLTLVHVLPDTEVRMWLDVPPTDEFWRTVEHQNREIQSEAVKTAEA
AVAGTGSLTVRQRSVSGNAVPTLVDLSKDAEMVVVGSRGLGAIGQRILGSVSRGLVHHAHCPVAVIHDDEPDAPERDRAP
VVVGIDGSPASELATAIAFDQASRRKVELIAVHAWSDPTIYAFPNEEWMTFKPQADEVLAERLAGWADRYPDVPVQRVVV
RDKAVHQLLEQSEHAQLVVVGSHGRGGFAGMLLGSVSSAVAQAARVPVIVARQS

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 31548; Mature: 31417

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSANQGIVVGVDGSPQGMRAVTWAAREAAGRDVPLTLVHVLPDTEVRMWLDVPPTDEF
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCHHH
WRTVEHQNREIQSEAVKTAEAAVAGTGSLTVRQRSVSGNAVPTLVDLSKDAEMVVVGSRG
HHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCEEEECCCCCCEEEECCCC
LGAIGQRILGSVSRGLVHHAHCPVAVIHDDEPDAPERDRAPVVVGIDGSPASELATAIAF
CHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
DQASRRKVELIAVHAWSDPTIYAFPNEEWMTFKPQADEVLAERLAGWADRYPDVPVQRVV
CCCCCCEEEEEEEEECCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
VRDKAVHQLLEQSEHAQLVVVGSHGRGGFAGMLLGSVSSAVAQAARVPVIVARQS
HHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure 
TTSANQGIVVGVDGSPQGMRAVTWAAREAAGRDVPLTLVHVLPDTEVRMWLDVPPTDEF
CCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCHHH
WRTVEHQNREIQSEAVKTAEAAVAGTGSLTVRQRSVSGNAVPTLVDLSKDAEMVVVGSRG
HHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCEEEECCCCCCEEEECCCC
LGAIGQRILGSVSRGLVHHAHCPVAVIHDDEPDAPERDRAPVVVGIDGSPASELATAIAF
CHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
DQASRRKVELIAVHAWSDPTIYAFPNEEWMTFKPQADEVLAERLAGWADRYPDVPVQRVV
CCCCCCEEEEEEEEECCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
VRDKAVHQLLEQSEHAQLVVVGSHGRGGFAGMLLGSVSSAVAQAARVPVIVARQS
HHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]