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The map label for this gene is actP [H]

Identifier: 119867147

GI number: 119867147

Start: 1181124

End: 1183448

Strand: Reverse

Name: actP [H]

Synonym: Mkms_1095

Alternate gene names: 119867147

Gene position: 1183448-1181124 (Counterclockwise)

Preceding gene: 119867148

Following gene: 119867146

Centisome position: 20.63

GC content: 72.17

Gene sequence:

>2325_bases
ATGGACGCCCAGACGCAGTGGGTTTCGCGCCTCCGCCCGCTGATCGAACCCGCGTTGGTGGTGCTCACCGTGGCCGCGCT
CGCCGCGGGCGGTATCGCGTGGCTGGCCGGATGGCGTTCCGCCGCTGACCTGTGCTGGATCGCCGGGACCGTGCTCGCCG
TGGTGCCGGCGGTCGTCTGGGTGGTCGCGGCATTGCGCCGGGGGCGGGTCGGCGTCGACGTGATCGCGGTGCTGTCACTC
GTCGGCACCCTGCTGGTGCACGAGTACCTGGCCGGCGCCCTGGTCGCGGTGATGCTGGCCGGTGGCCGTGCGCTGGACGC
CGCCGCCACGCGGCGTGCCAGCCATGACCTGCGCGCCCTGCTGGAACGCGCCCCACGGTTCGCGCGGCGACGGACCGACG
GGCAGGTCAGCGTGATCCCGCTCGACGAAGTCGCCGCCGATGACGTGTTGGTGGTCGGGCCGGGCGAGGTGGTGCCCGTG
GACGGGCGGGTGCTCGACGTGGTGGCGGTGCTGGACGAGTCGGCGTTGACCGGTGAGCCGCTACAGGTCGAACACGCTGT
CGGCGAACCGGTCCGCAGCGGTGTGGTGAACGCCGGCGGTGCGTTCGAGCTGCGCGCCACCGCCACGGCCGAGGACAGCA
CCTATGCCGGTATCGTCCGACTGGCCCGGCAGGCCGGCGCGGAAAGCGCACCCCTCGTGCGGTTGGCCGACCGCTACGCC
GCCTGGTTCCTGCCGCTGACGCTGGTGCTCGCCGGCGCGGCGTGGCTGGTCAGCGGCTCGGCGGTGCGGGCGGTGGCGGT
CCTGGTGGTGGCCACGCCGTGTCCGCTGCTCCTCGCGGCGCCGGTCGCGATCGTGTCGGGATTGTCGCGCGCCTCACGAA
GCGGGGTGATCATCCGCAGTGGCGGTGCACTCGAGAACCTGGGACACGCAACCACTTTGGTGATGGACAAGACGGGCACC
GTGACGATGGGCCGCCCGGTGGTCGTCGACGTGGCCGTCGCCCCCGGCCGCGAGCCGACCGAGCTGCTGCGGCAGGCGGC
GTCGGTGGATCAGTTCTCCCCGCACGTGCTGGCCGAGGCCATCGTCACCGAGGCGCGCAAGCGCGGTCAATCGCTGTCAC
TACCCAGCGACGTGCTCGAAGAACCGGGCCGCGGCGTCACCGCCACCGTCGAGGGCCAACGCATCTCGGTGGGAAAGCTG
CCGGACCGCAACGCCGTCAGCGGCTGGCAGCGCGGCGCGCTCAACCGGGCAGGTCTGGACGGCGCCGCGATCTCCTGGGT
GAGCATCGCGGGTGAACCGGTGGGCGCGGTGCTGTTGCGGGATCCGTTGCGCCGCGACGCACCGCGGACGATGCGCCGGT
TGCGGGCAGCGGGCCTGAACCGGTTGGTGATGCTGACCGGTGACCGCGCCGAACCGGCCCGCGAGGTCGCCACCGTGCTG
GGACTCGACGAGGTGTACGCCGAGCAGTCACCGGCCGACAAGGTCGCCGCGGTCCGCGGCGAACGCGAACGCGCCGTGAC
GGTGATGGTGGGCGACGGGATCAACGACGCTCCGGCACTGGCCGCGGCCACGGTGGGTGTCGCGATGGGTGCGCGCGGGG
CGACCGCGTCCTCCGAGGCCGCCGACGTCGTGTTGACGACCGATCGCGTCGACCGCCTCGCCGATGCGATGGACGTGGCC
CGCTGGTCGCGGCGCATCGCCGTTCAGAGCGCCGTGGTGGGCATGAGCCTGTCGCTGCTGGCGATGGTGGTTGCCGCATT
CGGCTGGCTGCCACCCGCCGCCGGCGCCCTCCTGCAGGAGGGCATCGACGTCGCGGTGATCCTCAATGCCCTGCGTGCGC
TGCGCGGAAACCCCGACTCCGCAATGGATCTCCCGCCGGAGACCGAACAGCTGCTGCATCGCTTCGCGGCCGAACACGAC
GAGCTCCGGGAAACCCTCCCACTGCTGCGCGACGCCGCCGACCGGCTGGCCGAGGCGCCGGACGCGGCCGCATTGGACTC
GCTGACGGCCGTGCACCGGTTGCTCACCGACCGGATCCTGCCGCACGAATTCGCCGAGGAGAACGAGCTGTATCCGGCGT
TGGCCCGCCCGCTGGGCAGCGGTGAGGCCACCGCCACCATGAGCCGCACCCACGCCGAGATCAAACGGCTCGCCGACCGC
ATCGGTACGCATGTCCGCCTCGCCGAATCGGCGGGCGCGGTCGAACCCGACCAGGTCGACGACCTGCTGGCGTGTCTGTA
CGGGCTCTACGCCCTGTTGCGGCTGCACTTCGTGCAGGAAGAGGAGAACTACTTCACCCTCACCGAGGACGAGCCCACAC
CCTGA

Upstream 100 bases:

>100_bases
TCTGGTTCGACATCCCGCACTTCATCATGGAGCAGAAGATGATGCGCGGCATCGCCGACCGCGCGCAACGGACACGGCAC
CGGGCCGCGGTCGGTTCGTG

Downstream 100 bases:

>100_bases
CCCGCGGCGGGCGGGGCCATTCGCCGCCGAGTACGGGCCGATGGTCCCTATCGCCGTACGCGGAGGCGCGATGTAGTCGA
AAGTATTCCCGCTCAGGAAC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MDAQTQWVSRLRPLIEPALVVLTVAALAAGGIAWLAGWRSAADLCWIAGTVLAVVPAVVWVVAALRRGRVGVDVIAVLSL
VGTLLVHEYLAGALVAVMLAGGRALDAAATRRASHDLRALLERAPRFARRRTDGQVSVIPLDEVAADDVLVVGPGEVVPV
DGRVLDVVAVLDESALTGEPLQVEHAVGEPVRSGVVNAGGAFELRATATAEDSTYAGIVRLARQAGAESAPLVRLADRYA
AWFLPLTLVLAGAAWLVSGSAVRAVAVLVVATPCPLLLAAPVAIVSGLSRASRSGVIIRSGGALENLGHATTLVMDKTGT
VTMGRPVVVDVAVAPGREPTELLRQAASVDQFSPHVLAEAIVTEARKRGQSLSLPSDVLEEPGRGVTATVEGQRISVGKL
PDRNAVSGWQRGALNRAGLDGAAISWVSIAGEPVGAVLLRDPLRRDAPRTMRRLRAAGLNRLVMLTGDRAEPAREVATVL
GLDEVYAEQSPADKVAAVRGERERAVTVMVGDGINDAPALAAATVGVAMGARGATASSEAADVVLTTDRVDRLADAMDVA
RWSRRIAVQSAVVGMSLSLLAMVVAAFGWLPPAAGALLQEGIDVAVILNALRALRGNPDSAMDLPPETEQLLHRFAAEHD
ELRETLPLLRDAADRLAEAPDAAALDSLTAVHRLLTDRILPHEFAEENELYPALARPLGSGEATATMSRTHAEIKRLADR
IGTHVRLAESAGAVEPDQVDDLLACLYGLYALLRLHFVQEEENYFTLTEDEPTP

Sequences:

>Translated_774_residues
MDAQTQWVSRLRPLIEPALVVLTVAALAAGGIAWLAGWRSAADLCWIAGTVLAVVPAVVWVVAALRRGRVGVDVIAVLSL
VGTLLVHEYLAGALVAVMLAGGRALDAAATRRASHDLRALLERAPRFARRRTDGQVSVIPLDEVAADDVLVVGPGEVVPV
DGRVLDVVAVLDESALTGEPLQVEHAVGEPVRSGVVNAGGAFELRATATAEDSTYAGIVRLARQAGAESAPLVRLADRYA
AWFLPLTLVLAGAAWLVSGSAVRAVAVLVVATPCPLLLAAPVAIVSGLSRASRSGVIIRSGGALENLGHATTLVMDKTGT
VTMGRPVVVDVAVAPGREPTELLRQAASVDQFSPHVLAEAIVTEARKRGQSLSLPSDVLEEPGRGVTATVEGQRISVGKL
PDRNAVSGWQRGALNRAGLDGAAISWVSIAGEPVGAVLLRDPLRRDAPRTMRRLRAAGLNRLVMLTGDRAEPAREVATVL
GLDEVYAEQSPADKVAAVRGERERAVTVMVGDGINDAPALAAATVGVAMGARGATASSEAADVVLTTDRVDRLADAMDVA
RWSRRIAVQSAVVGMSLSLLAMVVAAFGWLPPAAGALLQEGIDVAVILNALRALRGNPDSAMDLPPETEQLLHRFAAEHD
ELRETLPLLRDAADRLAEAPDAAALDSLTAVHRLLTDRILPHEFAEENELYPALARPLGSGEATATMSRTHAEIKRLADR
IGTHVRLAESAGAVEPDQVDDLLACLYGLYALLRLHFVQEEENYFTLTEDEPTP
>Mature_774_residues
MDAQTQWVSRLRPLIEPALVVLTVAALAAGGIAWLAGWRSAADLCWIAGTVLAVVPAVVWVVAALRRGRVGVDVIAVLSL
VGTLLVHEYLAGALVAVMLAGGRALDAAATRRASHDLRALLERAPRFARRRTDGQVSVIPLDEVAADDVLVVGPGEVVPV
DGRVLDVVAVLDESALTGEPLQVEHAVGEPVRSGVVNAGGAFELRATATAEDSTYAGIVRLARQAGAESAPLVRLADRYA
AWFLPLTLVLAGAAWLVSGSAVRAVAVLVVATPCPLLLAAPVAIVSGLSRASRSGVIIRSGGALENLGHATTLVMDKTGT
VTMGRPVVVDVAVAPGREPTELLRQAASVDQFSPHVLAEAIVTEARKRGQSLSLPSDVLEEPGRGVTATVEGQRISVGKL
PDRNAVSGWQRGALNRAGLDGAAISWVSIAGEPVGAVLLRDPLRRDAPRTMRRLRAAGLNRLVMLTGDRAEPAREVATVL
GLDEVYAEQSPADKVAAVRGERERAVTVMVGDGINDAPALAAATVGVAMGARGATASSEAADVVLTTDRVDRLADAMDVA
RWSRRIAVQSAVVGMSLSLLAMVVAAFGWLPPAAGALLQEGIDVAVILNALRALRGNPDSAMDLPPETEQLLHRFAAEHD
ELRETLPLLRDAADRLAEAPDAAALDSLTAVHRLLTDRILPHEFAEENELYPALARPLGSGEATATMSRTHAEIKRLADR
IGTHVRLAESAGAVEPDQVDDLLACLYGLYALLRLHFVQEEENYFTLTEDEPTP

Specific function: Involved in copper efflux [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=591, Percent_Identity=30.2876480541455, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI115529486, Length=605, Percent_Identity=27.7685950413223, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI55743073, Length=510, Percent_Identity=31.3725490196078, Blast_Score=180, Evalue=4e-45,
Organism=Escherichia coli, GI1786691, Length=554, Percent_Identity=35.1985559566787, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789879, Length=593, Percent_Identity=32.0404721753794, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786914, Length=524, Percent_Identity=26.9083969465649, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17556548, Length=598, Percent_Identity=29.4314381270903, Blast_Score=176, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320475, Length=555, Percent_Identity=28.8288288288288, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319772, Length=547, Percent_Identity=25.2285191956124, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6325221, Length=557, Percent_Identity=25.3141831238779, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321430, Length=557, Percent_Identity=24.9551166965889, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321271, Length=223, Percent_Identity=24.6636771300448, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221329854, Length=353, Percent_Identity=30.5949008498584, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.4 [H]

Molecular weight: Translated: 81327; Mature: 81327

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAQTQWVSRLRPLIEPALVVLTVAALAAGGIAWLAGWRSAADLCWIAGTVLAVVPAVVW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAALRRGRVGVDVIAVLSLVGTLLVHEYLAGALVAVMLAGGRALDAAATRRASHDLRAL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LERAPRFARRRTDGQVSVIPLDEVAADDVLVVGPGEVVPVDGRVLDVVAVLDESALTGEP
HHHHHHHHHHCCCCCEEEEEHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHCCCCCCCC
LQVEHAVGEPVRSGVVNAGGAFELRATATAEDSTYAGIVRLARQAGAESAPLVRLADRYA
CEEHHHHCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
AWFLPLTLVLAGAAWLVSGSAVRAVAVLVVATPCPLLLAAPVAIVSGLSRASRSGVIIRS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEC
GGALENLGHATTLVMDKTGTVTMGRPVVVDVAVAPGREPTELLRQAASVDQFSPHVLAEA
CCCHHHCCCCEEEEEECCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHH
IVTEARKRGQSLSLPSDVLEEPGRGVTATVEGQRISVGKLPDRNAVSGWQRGALNRAGLD
HHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHHHHCCCCCCCCC
GAAISWVSIAGEPVGAVLLRDPLRRDAPRTMRRLRAAGLNRLVMLTGDRAEPAREVATVL
CHHHHHHEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
GLDEVYAEQSPADKVAAVRGERERAVTVMVGDGINDAPALAAATVGVAMGARGATASSEA
HHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
ADVVLTTDRVDRLADAMDVARWSRRIAVQSAVVGMSLSLLAMVVAAFGWLPPAAGALLQE
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GIDVAVILNALRALRGNPDSAMDLPPETEQLLHRFAAEHDELRETLPLLRDAADRLAEAP
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAAALDSLTAVHRLLTDRILPHEFAEENELYPALARPLGSGEATATMSRTHAEIKRLADR
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IGTHVRLAESAGAVEPDQVDDLLACLYGLYALLRLHFVQEEENYFTLTEDEPTP
HCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure
MDAQTQWVSRLRPLIEPALVVLTVAALAAGGIAWLAGWRSAADLCWIAGTVLAVVPAVVW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAALRRGRVGVDVIAVLSLVGTLLVHEYLAGALVAVMLAGGRALDAAATRRASHDLRAL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LERAPRFARRRTDGQVSVIPLDEVAADDVLVVGPGEVVPVDGRVLDVVAVLDESALTGEP
HHHHHHHHHHCCCCCEEEEEHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHCCCCCCCC
LQVEHAVGEPVRSGVVNAGGAFELRATATAEDSTYAGIVRLARQAGAESAPLVRLADRYA
CEEHHHHCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
AWFLPLTLVLAGAAWLVSGSAVRAVAVLVVATPCPLLLAAPVAIVSGLSRASRSGVIIRS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEC
GGALENLGHATTLVMDKTGTVTMGRPVVVDVAVAPGREPTELLRQAASVDQFSPHVLAEA
CCCHHHCCCCEEEEEECCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHH
IVTEARKRGQSLSLPSDVLEEPGRGVTATVEGQRISVGKLPDRNAVSGWQRGALNRAGLD
HHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHHHHCCCCCCCCC
GAAISWVSIAGEPVGAVLLRDPLRRDAPRTMRRLRAAGLNRLVMLTGDRAEPAREVATVL
CHHHHHHEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
GLDEVYAEQSPADKVAAVRGERERAVTVMVGDGINDAPALAAATVGVAMGARGATASSEA
HHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
ADVVLTTDRVDRLADAMDVARWSRRIAVQSAVVGMSLSLLAMVVAAFGWLPPAAGALLQE
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GIDVAVILNALRALRGNPDSAMDLPPETEQLLHRFAAEHDELRETLPLLRDAADRLAEAP
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAAALDSLTAVHRLLTDRILPHEFAEENELYPALARPLGSGEATATMSRTHAEIKRLADR
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IGTHVRLAESAGAVEPDQVDDLLACLYGLYALLRLHFVQEEENYFTLTEDEPTP
HCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]