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The map label for this gene is ubiB [C]

Identifier: 119867024

GI number: 119867024

Start: 1060701

End: 1062059

Strand: Reverse

Name: ubiB [C]

Synonym: Mkms_0972

Alternate gene names: 119867024

Gene position: 1062059-1060701 (Counterclockwise)

Preceding gene: 119867025

Following gene: 119867023

Centisome position: 18.51

GC content: 66.3

Gene sequence:

>1359_bases
ATGAGTGCCACGCGAAAGACCCAGCACCGAGAGGTGGCCAGGCTGGACCGGGTGCCGTTGCCGGTCGAGGCCGCACGCTT
CGGCGCGACCGGGTGGCAGGTCACCCGCACCGGCGCCCGCGTCGTCACGAACCTCCGCGGACGCGGCAGCCTCTCGCAGA
AGATCGTCAAACAGGTCCCGCAGACCTTCGCCGATCTCGGCCCCACCTACGTCAAATTCGGCCAGATCATCGCGTCGAGT
CCGGGCGCGTTCGGCGAAGGGCTGTCCAAGGAGTTCCGCAGCCTGCTCGACCGGGTGCCGCCGGCCAACCCGGAGCAGGT
CGCCAAGCTGCTGCGGGAGGAACTCGGCGACGACCCGAAGAACCTCTACAAGAGCTTCGACGACACACCGTTCGCCTCGG
CGTCCATTGCGCAGGTGCACTACGCGACGCTGCACACCGGTGAAGAGGTCGTCGTCAAGATCCAGCGTCCCGGCATCCGC
CGGCGCGTCGCGGCGGACCTGCAGATCCTCAAGCGCGGCGCCCGACTGGTCGAGTTCGCCAAGCTCGGCCAGCGGCTGAG
CGCCCAGGACGTCGTCGCCGACTTCGCCGACAACCTCGCCGAGGAACTCGACTTCCGCCTCGAGGCGCAGTCGATGGACG
CGTGGGTGTCGCACATGCACGCCTCGCCGCTGGGCCGCAACATCCGGGTGCCTCAGGTGTACTGGGATCTGACCAGCGAG
AAGGTCCTGACGATGGAGCGGGTGTCGGGTATCCGCATCGACGACGCCGCGGCCATCCGCAAGAAGGGTTTCGACGGCAC
CGAACTGGTCAAGGCGCTGCTGTTCAGCCTGTTCGAGGGCGGGCTGCGGCACGGCCTGTTCCACGGGGACCTGCACGCCG
GCAACCTCTACATCGACGACGACGGCAAGATCGTCTTCTTCGACTTCGGCATCATGGGCCGCATCGACCCGCGCACCCGG
TGGCTGCTGCGAGAACTGGTGTACGCGCTGCTGGTCAAGAAGGATCACGCCGCGGCGGGCAAGATCGTCGTGATGATGGG
CGCCGTCGGCACGGTGAAGCCCGAAGCCCAGGCCGCCAAGGATCTGGAGAAGTTCGCCACGCCGCTGACCATGACGTCGC
TGGGCGATATGAGCTACGCCGAGATCGGCAGGCAGCTGTCGACGCTCGCCGACGCCTACGACGTGAAGCTGCCGCGTGAG
CTGGTGCTCATCGGTAAGCAGTTCCTCTACGTCGAGCGGTACATGAAGCTGCTGGCGCCGAAGTGGCAGATGATGAGCGA
TCCGCAGCTGACGGGGTACTTCGCCAACTTCATGGTCGACATCAGCCGTGAGCACAAAGAAGAAGGGCTGGAGGTCTGA

Upstream 100 bases:

>100_bases
GACGCCTACCAACCGCACAGCACCACCGTCGTCACCGGCGGATTGTGACCCGGGGCACACGCTTTTTCGCCTCACCGCGC
ATTTTGCAACACTGGAAGCC

Downstream 100 bases:

>100_bases
GGTGCAGGTCCGCGAAGGCAAGGCGTCGAACGGGGACGTCCAGATCCACTACGAGGACATGGGTGACCCCAACCACCCGG
CCGTGCTGCTCATCATGGGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSATRKTQHREVARLDRVPLPVEAARFGATGWQVTRTGARVVTNLRGRGSLSQKIVKQVPQTFADLGPTYVKFGQIIASS
PGAFGEGLSKEFRSLLDRVPPANPEQVAKLLREELGDDPKNLYKSFDDTPFASASIAQVHYATLHTGEEVVVKIQRPGIR
RRVAADLQILKRGARLVEFAKLGQRLSAQDVVADFADNLAEELDFRLEAQSMDAWVSHMHASPLGRNIRVPQVYWDLTSE
KVLTMERVSGIRIDDAAAIRKKGFDGTELVKALLFSLFEGGLRHGLFHGDLHAGNLYIDDDGKIVFFDFGIMGRIDPRTR
WLLRELVYALLVKKDHAAAGKIVVMMGAVGTVKPEAQAAKDLEKFATPLTMTSLGDMSYAEIGRQLSTLADAYDVKLPRE
LVLIGKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVDISREHKEEGLEV

Sequences:

>Translated_452_residues
MSATRKTQHREVARLDRVPLPVEAARFGATGWQVTRTGARVVTNLRGRGSLSQKIVKQVPQTFADLGPTYVKFGQIIASS
PGAFGEGLSKEFRSLLDRVPPANPEQVAKLLREELGDDPKNLYKSFDDTPFASASIAQVHYATLHTGEEVVVKIQRPGIR
RRVAADLQILKRGARLVEFAKLGQRLSAQDVVADFADNLAEELDFRLEAQSMDAWVSHMHASPLGRNIRVPQVYWDLTSE
KVLTMERVSGIRIDDAAAIRKKGFDGTELVKALLFSLFEGGLRHGLFHGDLHAGNLYIDDDGKIVFFDFGIMGRIDPRTR
WLLRELVYALLVKKDHAAAGKIVVMMGAVGTVKPEAQAAKDLEKFATPLTMTSLGDMSYAEIGRQLSTLADAYDVKLPRE
LVLIGKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVDISREHKEEGLEV
>Mature_451_residues
SATRKTQHREVARLDRVPLPVEAARFGATGWQVTRTGARVVTNLRGRGSLSQKIVKQVPQTFADLGPTYVKFGQIIASSP
GAFGEGLSKEFRSLLDRVPPANPEQVAKLLREELGDDPKNLYKSFDDTPFASASIAQVHYATLHTGEEVVVKIQRPGIRR
RVAADLQILKRGARLVEFAKLGQRLSAQDVVADFADNLAEELDFRLEAQSMDAWVSHMHASPLGRNIRVPQVYWDLTSEK
VLTMERVSGIRIDDAAAIRKKGFDGTELVKALLFSLFEGGLRHGLFHGDLHAGNLYIDDDGKIVFFDFGIMGRIDPRTRW
LLRELVYALLVKKDHAAAGKIVVMMGAVGTVKPEAQAAKDLEKFATPLTMTSLGDMSYAEIGRQLSTLADAYDVKLPREL
VLIGKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVDISREHKEEGLEV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=29.6703296703297, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI40254938, Length=250, Percent_Identity=30.4, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI217035081, Length=246, Percent_Identity=30.8943089430894, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI27363457, Length=270, Percent_Identity=30.3703703703704, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI217416386, Length=210, Percent_Identity=32.3809523809524, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI34147522, Length=272, Percent_Identity=27.2058823529412, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI2367309, Length=364, Percent_Identity=28.8461538461538, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17559152, Length=339, Percent_Identity=27.4336283185841, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=160, Percent_Identity=31.25, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323282, Length=303, Percent_Identity=28.7128712871287, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=319, Percent_Identity=28.5266457680251, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=252, Percent_Identity=24.6031746031746, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24662575, Length=304, Percent_Identity=29.6052631578947, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI22024280, Length=273, Percent_Identity=29.6703296703297, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859849, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50411; Mature: 50280

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATRKTQHREVARLDRVPLPVEAARFGATGWQVTRTGARVVTNLRGRGSLSQKIVKQVP
CCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHH
QTFADLGPTYVKFGQIIASSPGAFGEGLSKEFRSLLDRVPPANPEQVAKLLREELGDDPK
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
NLYKSFDDTPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRVAADLQILKRGARLVEFA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
KLGQRLSAQDVVADFADNLAEELDFRLEAQSMDAWVSHMHASPLGRNIRVPQVYWDLTSE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCC
KVLTMERVSGIRIDDAAAIRKKGFDGTELVKALLFSLFEGGLRHGLFHGDLHAGNLYIDD
HHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCEEECCEEECC
DGKIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVMMGAVGTVKPEAQAAK
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHH
DLEKFATPLTMTSLGDMSYAEIGRQLSTLADAYDVKLPRELVLIGKQFLYVERYMKLLAP
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
KWQMMSDPQLTGYFANFMVDISREHKEEGLEV
CHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SATRKTQHREVARLDRVPLPVEAARFGATGWQVTRTGARVVTNLRGRGSLSQKIVKQVP
CCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHH
QTFADLGPTYVKFGQIIASSPGAFGEGLSKEFRSLLDRVPPANPEQVAKLLREELGDDPK
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
NLYKSFDDTPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRVAADLQILKRGARLVEFA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
KLGQRLSAQDVVADFADNLAEELDFRLEAQSMDAWVSHMHASPLGRNIRVPQVYWDLTSE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCC
KVLTMERVSGIRIDDAAAIRKKGFDGTELVKALLFSLFEGGLRHGLFHGDLHAGNLYIDD
HHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCEEECCEEECC
DGKIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVMMGAVGTVKPEAQAAK
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHH
DLEKFATPLTMTSLGDMSYAEIGRQLSTLADAYDVKLPRELVLIGKQFLYVERYMKLLAP
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
KWQMMSDPQLTGYFANFMVDISREHKEEGLEV
CHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]