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The map label for this gene is pcoA [H]

Identifier: 119855090

GI number: 119855090

Start: 213334

End: 214890

Strand: Direct

Name: pcoA [H]

Synonym: Mkms_5702

Alternate gene names: 119855090

Gene position: 213334-214890 (Clockwise)

Preceding gene: 119855089

Following gene: 119855091

Centisome position: 70.62

GC content: 65.77

Gene sequence:

>1557_bases
ATGAACGGTCAGAGCGTCGGCACGACGATATTGACACGACGCACGTTTCTCGCGGCCACCCTCGCTGCCAGTACCGCCGC
CATGGCTGCGTGCGGAAAGCCCACAAGTGTCAACCCGGCTACGGATCCGATCGGCGCCGCCGAAGCCGCGCGGCCCCACA
CCGGGCGCACTGTCACTGCGGCGTTGACACCTGGGCCGGCGGACATCGATCTGGGCGGACCCGTCGCCCGCACACTGGCG
TACAACAACATTGTTCCCGGACCGTTGATCCGCGCCAACGTCGGCGACGAACTGGCGATTAGCGTCACCAACGGTCTGAA
CCACCCGTCTTCGCTGCACTGGCATGGCATCGCGCTGCGCAACGATATGGATGGGGCAACGCCGGCGACCCCGAACATCG
ACCCGTCCTCGAACTTCACTTACCGGTTTTCTGCGCCTCATCCCGGTACCTACTGGGCGCATCCGCACACCGGCCTCGAC
GCCGACTACGGACTCTACGCGCCGGTCATCATCGACGATCCGGCCGAACCGGGAGGCTACGACGCCGAGTGGATCGTGGT
GCTCGATGACTGGACCGACGGCATCGGCTCCAGTCCGCAGCAGCTCTACGAGGGGCTGCGTCCCATCTCGGGAGTCGGCG
GCCACTCGGGTGGCATGCCAGGCATGCCCGGCATGCCCGGCATGCCCGGCATGAGCGGAACACCTGGAATGCCAGGGGTT
CCCGGTGTCGGCGGCGTGGGCGCGAGCCCGCTTCTCGGGGGCGACGCGGGTGACGTCAGCTACCCCTTCTACCTGGCGAA
CGGTCGTATTCCGGCGGCACCGACCACTCTCACCGCTCGCCCTGGGCAGCGGATAAGGATGCGGATCATCAACGCCGCGT
CCGATACCGCTTTTCGGGTCGCGTTGGCCGGGCATCGGATGACCGTCACCCACACCGACGGCTTCCCTGTGGTGCCGACC
GAGGTGGACGCGCTTCTGATCGGCATGGGTGAGCGCTATGACGTGCTCATCACCACCGGTGACGGCGTGTTCTCCTTTGT
CGCTTCGGCCGAAGGGAAGAACGCGCTCGCGCGAGCCATACTGTCGACCGGTGCCGGTGCCGCACCCGATCCGACGTTCA
TGCCACCCGAACTGCAGCGCCGGGTCGGCACCGTCGGCGTGTTCACCGCCGCGCCCGAGGCGGTATTGGATGTCAGCAGG
GCCGATGTCGCTCTGTCGGCCCGGCTTTCCGGTTCCATGGCGTCCTACGACTGGACGATCAACGGCAGACCGTTCGAAGA
CACCGTCCCACTGACTGTGAGGCAAGGCCAGAAGGCGACGTTGACCTTCGCCAATACCACCATGATGTGGCATCCCATGC
ACCTGCACGGCCACACCTTTCAAGTGATCAAGCCGGACGGGACTCCGGGCCCACGCAAGGACACCGTCATCGTTCTGCCG
ATGCAGGAGCTGACGGTGGCGCTCGCCGCCGACAACCCGGGCGTCTGGATGATGCACTGCCACAACACCTATCACCAGGA
AGCCGGCATGATGACGAGCCTGAACTACTCGCCCTAG

Upstream 100 bases:

>100_bases
CACCGCAGCGCCGCCAGGACATTGAAATCCAGCGCGACGCTCCGTTGCCCGGCCTCACCGCCGCCGATTGCGTCGCGACG
ACGAACCCCCCGCAACGACC

Downstream 100 bases:

>100_bases
CCCGGTGCCGCGCCCTTCGCACGGTCAGCGGCAATGAGGCCCAAAGACCTTGAAGCGCAGTGCTCTTGACTCTGTCGGGA
CGAGACGCAAACCGTAAGAC

Product: multicopper oxidase, type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNGQSVGTTILTRRTFLAATLAASTAAMAACGKPTSVNPATDPIGAAEAARPHTGRTVTAALTPGPADIDLGGPVARTLA
YNNIVPGPLIRANVGDELAISVTNGLNHPSSLHWHGIALRNDMDGATPATPNIDPSSNFTYRFSAPHPGTYWAHPHTGLD
ADYGLYAPVIIDDPAEPGGYDAEWIVVLDDWTDGIGSSPQQLYEGLRPISGVGGHSGGMPGMPGMPGMPGMSGTPGMPGV
PGVGGVGASPLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAASDTAFRVALAGHRMTVTHTDGFPVVPT
EVDALLIGMGERYDVLITTGDGVFSFVASAEGKNALARAILSTGAGAAPDPTFMPPELQRRVGTVGVFTAAPEAVLDVSR
ADVALSARLSGSMASYDWTINGRPFEDTVPLTVRQGQKATLTFANTTMMWHPMHLHGHTFQVIKPDGTPGPRKDTVIVLP
MQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSP

Sequences:

>Translated_518_residues
MNGQSVGTTILTRRTFLAATLAASTAAMAACGKPTSVNPATDPIGAAEAARPHTGRTVTAALTPGPADIDLGGPVARTLA
YNNIVPGPLIRANVGDELAISVTNGLNHPSSLHWHGIALRNDMDGATPATPNIDPSSNFTYRFSAPHPGTYWAHPHTGLD
ADYGLYAPVIIDDPAEPGGYDAEWIVVLDDWTDGIGSSPQQLYEGLRPISGVGGHSGGMPGMPGMPGMPGMSGTPGMPGV
PGVGGVGASPLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAASDTAFRVALAGHRMTVTHTDGFPVVPT
EVDALLIGMGERYDVLITTGDGVFSFVASAEGKNALARAILSTGAGAAPDPTFMPPELQRRVGTVGVFTAAPEAVLDVSR
ADVALSARLSGSMASYDWTINGRPFEDTVPLTVRQGQKATLTFANTTMMWHPMHLHGHTFQVIKPDGTPGPRKDTVIVLP
MQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSP
>Mature_518_residues
MNGQSVGTTILTRRTFLAATLAASTAAMAACGKPTSVNPATDPIGAAEAARPHTGRTVTAALTPGPADIDLGGPVARTLA
YNNIVPGPLIRANVGDELAISVTNGLNHPSSLHWHGIALRNDMDGATPATPNIDPSSNFTYRFSAPHPGTYWAHPHTGLD
ADYGLYAPVIIDDPAEPGGYDAEWIVVLDDWTDGIGSSPQQLYEGLRPISGVGGHSGGMPGMPGMPGMPGMSGTPGMPGV
PGVGGVGASPLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAASDTAFRVALAGHRMTVTHTDGFPVVPT
EVDALLIGMGERYDVLITTGDGVFSFVASAEGKNALARAILSTGAGAAPDPTFMPPELQRRVGTVGVFTAAPEAVLDVSR
ADVALSARLSGSMASYDWTINGRPFEDTVPLTVRQGQKATLTFANTTMMWHPMHLHGHTFQVIKPDGTPGPRKDTVIVLP
MQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSP

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=568, Percent_Identity=24.2957746478873, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=305, Percent_Identity=24.2622950819672, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574104, Length=346, Percent_Identity=26.878612716763, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859919, Length=307, Percent_Identity=23.1270358306189, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54001; Mature: 54001

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGQSVGTTILTRRTFLAATLAASTAAMAACGKPTSVNPATDPIGAAEAARPHTGRTVTA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCEEEE
ALTPGPADIDLGGPVARTLAYNNIVPGPLIRANVGDELAISVTNGLNHPSSLHWHGIALR
EECCCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEEEEEEE
NDMDGATPATPNIDPSSNFTYRFSAPHPGTYWAHPHTGLDADYGLYAPVIIDDPAEPGGY
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEEEEEECCCCCCCC
DAEWIVVLDDWTDGIGSSPQQLYEGLRPISGVGGHSGGMPGMPGMPGMPGMSGTPGMPGV
CCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGVGGVGASPLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAASDTAFRV
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEE
ALAGHRMTVTHTDGFPVVPTEVDALLIGMGERYDVLITTGDGVFSFVASAEGKNALARAI
EEECCEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEHHHCCCCHHHHHHHH
LSTGAGAAPDPTFMPPELQRRVGTVGVFTAAPEAVLDVSRADVALSARLSGSMASYDWTI
HHCCCCCCCCCCCCCHHHHHHHCEEEEEECCCHHHHCCCCCCEEEEEEECCCEEEEEEEE
NGRPFEDTVPLTVRQGQKATLTFANTTMMWHPMHLHGHTFQVIKPDGTPGPRKDTVIVLP
CCCCCCCCCCEEEECCCEEEEEEEEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEEEEE
MQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSP
HHHEEEEEEECCCCEEEEEECCCHHHHCCCEEECCCCC
>Mature Secondary Structure
MNGQSVGTTILTRRTFLAATLAASTAAMAACGKPTSVNPATDPIGAAEAARPHTGRTVTA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCEEEE
ALTPGPADIDLGGPVARTLAYNNIVPGPLIRANVGDELAISVTNGLNHPSSLHWHGIALR
EECCCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEEEEEEE
NDMDGATPATPNIDPSSNFTYRFSAPHPGTYWAHPHTGLDADYGLYAPVIIDDPAEPGGY
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEEEEEECCCCCCCC
DAEWIVVLDDWTDGIGSSPQQLYEGLRPISGVGGHSGGMPGMPGMPGMPGMSGTPGMPGV
CCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGVGGVGASPLLGGDAGDVSYPFYLANGRIPAAPTTLTARPGQRIRMRIINAASDTAFRV
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEE
ALAGHRMTVTHTDGFPVVPTEVDALLIGMGERYDVLITTGDGVFSFVASAEGKNALARAI
EEECCEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEHHHCCCCHHHHHHHH
LSTGAGAAPDPTFMPPELQRRVGTVGVFTAAPEAVLDVSRADVALSARLSGSMASYDWTI
HHCCCCCCCCCCCCCHHHHHHHCEEEEEECCCHHHHCCCCCCEEEEEEECCCEEEEEEEE
NGRPFEDTVPLTVRQGQKATLTFANTTMMWHPMHLHGHTFQVIKPDGTPGPRKDTVIVLP
CCCCCCCCCCEEEECCCEEEEEEEEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEEEEE
MQELTVALAADNPGVWMMHCHNTYHQEAGMMTSLNYSP
HHHEEEEEEECCCCEEEEEECCCHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]