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The map label for this gene is garR [H]

Identifier: 119855041

GI number: 119855041

Start: 161320

End: 162198

Strand: Direct

Name: garR [H]

Synonym: Mkms_5650

Alternate gene names: 119855041

Gene position: 161320-162198 (Clockwise)

Preceding gene: 119855040

Following gene: 119855042

Centisome position: 53.4

GC content: 64.05

Gene sequence:

>879_bases
ATGAGGCGGGTCGGCGTGATCGGCTTGGGCGGCATGGGTTCCGCGCTGGCGGCGTCACTTCTTGCGACGGACCATTACGT
AGTCTGTTTCGACATTCGGCCCGACGTATTACGCCCAATTGTCGAGCTAGGCGCCGAGGCTGCTGCGGACGCGCGTGAGT
TGGCCGGCGCATGTGATGTCGTTTTGACGTTCCTCCCGGGGCCGAGTCAGGTGCTGGAGGTGGCGCTCGGGTCGGAGCGA
GGTGTCCTGGCCGGCCTTGCCGACGGGGCCGCCCTGCTGGATATGTCGACCTGTAATCCCGAGGTTGCAGCAATCATCGG
TCAGGCCTACGACGCGGCTGGGAGGCGTTTTGTCGATTGCCCCGTCAGCCGAAAGGCGCCGAACATGACCGTTCTGGTCG
GAGGCCCAAGCGGGGTGCTCGGCCCTGATGCCGATGTCCTCGCCGCCGTCTCGCGCACCTTGGTGTACTGCGGCCATCGA
GGTGCGGGATATGCCACCAAGCTCCTCAACCAGCACATCAAGTACAGCTGGTACCTCGCTTCGGCGGAAGCCCTCTTAAT
CGCTGAGGCGATGGGATTGAATGCCGGCGAGGTAGCCGACGCGATCGCGGAGTGCAGCGGGGGGGACTCGGGTCTCACCA
CGGCGGCGGCGTACTTCCGCCACGACACCGAGTCAGTTAGAAACCGCGCCCCCGCTAGCACCATTACGAAAGACTCCGCG
CTCGCGGAACGAATGGCGACGAACGCCGGTATCCGCAGCAGGACGCTTGAGCCCGTCGTGGACTTCTTCCAAAGCGTTGC
GGCCTCGGAGTTTCGCGACCGTGCCTACCCCGAAAGCACAGAACTTCTTCAACGAATCCGGTCGATGCCTCCGAAGTGA

Upstream 100 bases:

>100_bases
CGCTGGGATAGCCGTCTGTTGAGCCACCATGCCGCAGATGCCGGCATTCGCCGACTGTGTCGGTAGTCGGTTTACGGCCT
GACATTCGGTGGTCGGTGTC

Downstream 100 bases:

>100_bases
ACCCCTACGCCGTGACAGTAAGGCGCTCACGCTGTATAGCTAACTGAATTGTAAACGGGGCCGAATATCGGTGAGCGGAA
AGAAAGACCACCGACCATTT

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSER
GVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLVGGPSGVLGPDADVLAAVSRTLVYCGHR
GAGYATKLLNQHIKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSA
LAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK

Sequences:

>Translated_292_residues
MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSER
GVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLVGGPSGVLGPDADVLAAVSRTLVYCGHR
GAGYATKLLNQHIKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSA
LAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
>Mature_292_residues
MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSER
GVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLVGGPSGVLGPDADVLAAVSRTLVYCGHR
GAGYATKLLNQHIKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSA
LAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=209, Percent_Identity=28.2296650717703, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI40556376, Length=242, Percent_Identity=23.9669421487603, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI145693186, Length=205, Percent_Identity=37.0731707317073, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790315, Length=220, Percent_Identity=30.4545454545455, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786719, Length=195, Percent_Identity=28.7179487179487, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24655230, Length=211, Percent_Identity=28.436018957346, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922568, Length=211, Percent_Identity=28.436018957346, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574115, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30481; Mature: 30481

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDV
CCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHH
VLTFLPGPSQVLEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDC
HHEECCCHHHHHHHHHCCCCCEEEECCCCHHEEECCCCCHHHHHHHHHHHHHCCCEEEEC
PVSRKAPNMTVLVGGPSGVLGPDADVLAAVSRTLVYCGHRGAGYATKLLNQHIKYSWYLA
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEE
SAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSA
CHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
LAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDV
CCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHH
VLTFLPGPSQVLEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDC
HHEECCCHHHHHHHHHCCCCCEEEECCCCHHEEECCCCCHHHHHHHHHHHHHCCCEEEEC
PVSRKAPNMTVLVGGPSGVLGPDADVLAAVSRTLVYCGHRGAGYATKLLNQHIKYSWYLA
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEE
SAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSA
CHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
LAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]