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The map label for this gene is bphB [H]

Identifier: 119855008

GI number: 119855008

Start: 125841

End: 126692

Strand: Direct

Name: bphB [H]

Synonym: Mkms_5615

Alternate gene names: 119855008

Gene position: 125841-126692 (Clockwise)

Preceding gene: 119855007

Following gene: 119855009

Centisome position: 41.66

GC content: 63.73

Gene sequence:

>852_bases
GTGGGTTGGTTGACCGGGCAGGTCGCCCTGGTGACCGGCGGGGCAGCCGGAATCGGTTTGGCCGTGGTCGAGCGTTTCTT
GGCCGAGGGCGCATGCGTGGGCGTCCTGGATCGCTCGGAAGGCGACCTGGCTACCATCGGCAACGCCGACGGCAGGCTGA
TCGCGGTATCGGGTGACGTGACGTCGTATGCAGACAACGTCATGGCGGTGCGCGAAACGGTCGATGCGTTCGGAAAGCTC
GACGTCTTCGTCGGCAACGCTGGGATCTTCGATTACTTTGCCCCTTTGGTGGGTTTCGACGGAGCCGACCTCAGCAGCGC
CTTCGATGAGATCTTCGCGGTCAATGTCAAGGGTTACCTCCTTGGTGCCAGGGCCGCCGTTCCTGAACTCCTCAAAAGCG
ATGGCCCGAGCATGATCTTCACCGTCTCCAACTCTGGTTTCTATGCCTCCGGTGGCGGCCCGCTGTACACCGCTTCCAAG
CACGTAGTCGTTGGCGTGGTGCGTGAACTGGCCTACGAGTTGGCGCCGAAGATCAGGGTGAATGGCGTCGCTCCAGGCGG
CACGGTAACGGGCCTGCGTGGGATCGAGGACCTCGGCCAGGGTCAGGACGTGTTGTCATCGGTGCCCGGCGTCGCCGACA
TGATGAGTATCACGAACCCTCTGCAGTACGCGCAGCAGCCCGCCGATCATGCCGGCCTGTATCTGCTACTCGCGTCTGCA
GACAACTCGCGAGCGGTGACCGGCGTCGTCATCAACAGTGACGGCGGCTTGGGCGTGCGGGGCCTGAACCAGCCGTCCGG
AGGGCTGGAACTTGCCACCGGCGCGATGCGCATCGACGTCGGGTCAACATAG

Upstream 100 bases:

>100_bases
GTTCCAACAGCGCTGCGCGGATAGACCACGCATTCCTCGACGAGGAGCCTAGTGAGCAAATGAAGGAACTGGATCGGTGC
GCATCACAGAGGGGTGAAGT

Downstream 100 bases:

>100_bases
GAGGTTTTACACATGTTGGTGAAAGCGTTGGGTTATGTGGGTGTGGAGTCTCCGGATGCGAAGGAGTGGTTGGCGTTCGG
TCCGGAGGTTTTGGGGATGG

Product: 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase

Products: NA

Alternate protein names: 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase; 2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase; Biphenyl-2,3-dihydro-2,3-diol dehydrogenase; Biphenyl-cis-diol dehydrogenase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MGWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRLIAVSGDVTSYADNVMAVRETVDAFGKL
DVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPELLKSDGPSMIFTVSNSGFYASGGGPLYTASK
HVVVGVVRELAYELAPKIRVNGVAPGGTVTGLRGIEDLGQGQDVLSSVPGVADMMSITNPLQYAQQPADHAGLYLLLASA
DNSRAVTGVVINSDGGLGVRGLNQPSGGLELATGAMRIDVGST

Sequences:

>Translated_283_residues
MGWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRLIAVSGDVTSYADNVMAVRETVDAFGKL
DVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPELLKSDGPSMIFTVSNSGFYASGGGPLYTASK
HVVVGVVRELAYELAPKIRVNGVAPGGTVTGLRGIEDLGQGQDVLSSVPGVADMMSITNPLQYAQQPADHAGLYLLLASA
DNSRAVTGVVINSDGGLGVRGLNQPSGGLELATGAMRIDVGST
>Mature_282_residues
GWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRLIAVSGDVTSYADNVMAVRETVDAFGKLD
VFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYLLGARAAVPELLKSDGPSMIFTVSNSGFYASGGGPLYTASKH
VVVGVVRELAYELAPKIRVNGVAPGGTVTGLRGIEDLGQGQDVLSSVPGVADMMSITNPLQYAQQPADHAGLYLLLASAD
NSRAVTGVVINSDGGLGVRGLNQPSGGLELATGAMRIDVGST

Specific function: Converts Cis-3-(3-Carboxyethyl)-3,5-Cyclohexadiene-1,2- Diol (Pp-Dihydrodiol) Into 3-(2,3-Dihydroxylphenyl)Propionate (Dhpp). [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=29.7709923664122, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=32.7868852459016, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=249, Percent_Identity=29.3172690763052, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723750, Length=267, Percent_Identity=28.8389513108614, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI10190704, Length=271, Percent_Identity=27.3062730627306, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=31.2252964426877, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI31542939, Length=233, Percent_Identity=26.1802575107296, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4504505, Length=209, Percent_Identity=33.4928229665072, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788891, Length=273, Percent_Identity=48.3516483516484, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1787526, Length=260, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=29.811320754717, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=34, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=213, Percent_Identity=30.5164319248826, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787905, Length=278, Percent_Identity=29.8561151079137, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367365, Length=262, Percent_Identity=29.3893129770992, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=30.2325581395349, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789208, Length=267, Percent_Identity=27.7153558052434, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=31.9391634980989, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=28.8389513108614, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=280, Percent_Identity=26.7857142857143, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=278, Percent_Identity=29.136690647482, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=215, Percent_Identity=29.3023255813954, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=28.9473684210526, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=28.3018867924528, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=27.9245283018868, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=286, Percent_Identity=27.972027972028, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=28.6764705882353, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=274, Percent_Identity=29.1970802919708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=273, Percent_Identity=28.9377289377289, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=280, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=27.3408239700375, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=261, Percent_Identity=31.4176245210728, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=268, Percent_Identity=27.6119402985075, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=24.8175182481752, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=269, Percent_Identity=28.2527881040892, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355319, Length=216, Percent_Identity=31.9444444444444, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=33.6787564766839, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=32.9896907216495, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24643142, Length=262, Percent_Identity=31.2977099236641, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571526, Length=266, Percent_Identity=29.3233082706767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357041, Length=202, Percent_Identity=29.2079207920792, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017711
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.56 [H]

Molecular weight: Translated: 28728; Mature: 28597

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRLIAVSGDV
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEEECCH
TSYADNVMAVRETVDAFGKLDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYL
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHEEEEECEEE
LGARAAVPELLKSDGPSMIFTVSNSGFYASGGGPLYTASKHVVVGVVRELAYELAPKIRV
EECHHHHHHHHHCCCCCEEEEEECCCEEECCCCCEEECCCHHHHHHHHHHHHHHCCCEEE
NGVAPGGTVTGLRGIEDLGQGQDVLSSVPGVADMMSITNPLQYAQQPADHAGLYLLLASA
EEECCCCCCHHHHCHHHHCCCHHHHHHCCCHHHHHHHHCHHHHHHCCCCCCCEEEEEEEC
DNSRAVTGVVINSDGGLGVRGLNQPSGGLELATGAMRIDVGST
CCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCEEEEECCCC
>Mature Secondary Structure 
GWLTGQVALVTGGAAGIGLAVVERFLAEGACVGVLDRSEGDLATIGNADGRLIAVSGDV
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEEECCH
TSYADNVMAVRETVDAFGKLDVFVGNAGIFDYFAPLVGFDGADLSSAFDEIFAVNVKGYL
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHEEEEECEEE
LGARAAVPELLKSDGPSMIFTVSNSGFYASGGGPLYTASKHVVVGVVRELAYELAPKIRV
EECHHHHHHHHHCCCCCEEEEEECCCEEECCCCCEEECCCHHHHHHHHHHHHHHCCCEEE
NGVAPGGTVTGLRGIEDLGQGQDVLSSVPGVADMMSITNPLQYAQQPADHAGLYLLLASA
EEECCCCCCHHHHCHHHHCCCHHHHHHCCCHHHHHHHHCHHHHHHCCCCCCCEEEEEEEC
DNSRAVTGVVINSDGGLGVRGLNQPSGGLELATGAMRIDVGST
CCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8048958 [H]