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The map label for this gene is 119854951

Identifier: 119854951

GI number: 119854951

Start: 66747

End: 67733

Strand: Direct

Name: 119854951

Synonym: Mkms_5557

Alternate gene names: NA

Gene position: 66747-67733 (Clockwise)

Preceding gene: 119854950

Following gene: 119854955

Centisome position: 22.1

GC content: 66.87

Gene sequence:

>987_bases
GTGACCCGCGCATCGTTGTCCCCCGACCGCCTCGTGGCCCCTGCGCCCATGTTGGCGACGCTGGGACCGGCCCCGCGCGG
CGGTCAGTTTGCTGTAGAGGTGAAGTTTGATGGCCAGCGGGGAATATTGACTGTTGATCGCCGCGTGCAGGTGACGTCTC
GCAATGGGGCGGACATCACTGAAACTTTCCCCGAGTTGTCCGCCGTCGCGGCTGCGGTCGGCGGCCGTCGGATGGTCCTT
GACGGTGAGATCGTCGCCGTCGACGAGCACGGCCGCCCGTCGTTTAGACGGCTTCAGCGGCGGTGGCCTCAGCAGCGGCG
GCCCGGCGCGCAGCTCGTGCGTGAGGTTCCCACGCGTTTTCTAGCCTTCGATGTGATGAACATCGAGGGCGAAGACATCA
CGCACTGGCCTTACCGGGAGCGCCGCGAGCTGTTGGACACGCTGATGGTGATGGAGAGTTCGCCAGCACTGACGGTGCCT
AGGCATTGGACCGATGTCGCGCCTGCCGACATGCTCGCTATATGCGCTGATCAGCACCACGAGGGCATCGTGTGTAAACG
GCTGGATTCGCCATACCGGTCGGGCCGGTCCCGGGACTGGATTAAGTGCCCAGTGCGCGCGACAACCGAGGCGGTGATCG
TGGGGGCGTTCGCCGGCCATCGCGGCGAGGTTGGGACCCTGGTCTTGGCCGCCCACGACGAGGCGGGACAACTCGTGCTG
TTGGGTCAGGTGGGCACGGGTTTTAGTGGTGCCGAGCGTCGCCGTCTGGCCACACTGTTGGCCGGGACTGAGGTCTCCGC
GCCGCCGGTTGCGGTGGGGGCGTCGATGTCGGGGGTCCAGTGGTTCAAGCCGCGGTATGTCGGTGAGGTTGCCTACCGCG
AGTATCACGCGGGCAAAGGTCTGCGCCATGCGTCGTGGAAGGGGCTGCGTTCCGAGCCCGCGTCGGGGGTGTGTTTGCCG
CGCGATGCCGGCGCGGCGCCCGGCTAA

Upstream 100 bases:

>100_bases
CACCTGCAAATCCTCTGGCCAGACGATCGAGATTTGCGACATGGTTTTACACCTGACGCGGTGACAATGACCCGCTGCCA
CCGGTGGGTACCTTCGAAGC

Downstream 100 bases:

>100_bases
TTACGAGTGCGTGCCCCACCAGGCGTAGAGCTGGTCCAGCCGAGGGTCGTTGGGGCCATCGGATTGCACGTCGGCGATGA
GCCGTTGCGCGTCGTTGGTC

Product: DNA ligase (ATP)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTRASLSPDRLVAPAPMLATLGPAPRGGQFAVEVKFDGQRGILTVDRRVQVTSRNGADITETFPELSAVAAAVGGRRMVL
DGEIVAVDEHGRPSFRRLQRRWPQQRRPGAQLVREVPTRFLAFDVMNIEGEDITHWPYRERRELLDTLMVMESSPALTVP
RHWTDVAPADMLAICADQHHEGIVCKRLDSPYRSGRSRDWIKCPVRATTEAVIVGAFAGHRGEVGTLVLAAHDEAGQLVL
LGQVGTGFSGAERRRLATLLAGTEVSAPPVAVGASMSGVQWFKPRYVGEVAYREYHAGKGLRHASWKGLRSEPASGVCLP
RDAGAAPG

Sequences:

>Translated_328_residues
MTRASLSPDRLVAPAPMLATLGPAPRGGQFAVEVKFDGQRGILTVDRRVQVTSRNGADITETFPELSAVAAAVGGRRMVL
DGEIVAVDEHGRPSFRRLQRRWPQQRRPGAQLVREVPTRFLAFDVMNIEGEDITHWPYRERRELLDTLMVMESSPALTVP
RHWTDVAPADMLAICADQHHEGIVCKRLDSPYRSGRSRDWIKCPVRATTEAVIVGAFAGHRGEVGTLVLAAHDEAGQLVL
LGQVGTGFSGAERRRLATLLAGTEVSAPPVAVGASMSGVQWFKPRYVGEVAYREYHAGKGLRHASWKGLRSEPASGVCLP
RDAGAAPG
>Mature_327_residues
TRASLSPDRLVAPAPMLATLGPAPRGGQFAVEVKFDGQRGILTVDRRVQVTSRNGADITETFPELSAVAAAVGGRRMVLD
GEIVAVDEHGRPSFRRLQRRWPQQRRPGAQLVREVPTRFLAFDVMNIEGEDITHWPYRERRELLDTLMVMESSPALTVPR
HWTDVAPADMLAICADQHHEGIVCKRLDSPYRSGRSRDWIKCPVRATTEAVIVGAFAGHRGEVGTLVLAAHDEAGQLVLL
GQVGTGFSGAERRRLATLLAGTEVSAPPVAVGASMSGVQWFKPRYVGEVAYREYHAGKGLRHASWKGLRSEPASGVCLPR
DAGAAPG

Specific function: Unknown

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=300, Percent_Identity=26, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320038, Length=307, Percent_Identity=25.7328990228013, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR014146
- InterPro:   IPR002755
- InterPro:   IPR014144
- InterPro:   IPR014145
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF01896 DNA_primase_S [H]

EC number: NA

Molecular weight: Translated: 35662; Mature: 35531

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRASLSPDRLVAPAPMLATLGPAPRGGQFAVEVKFDGQRGILTVDRRVQVTSRNGADIT
CCCCCCCCCCEECCCCHHHHCCCCCCCCEEEEEEEECCCCCEEEECCEEEEECCCCCCHH
ETFPELSAVAAAVGGRRMVLDGEIVAVDEHGRPSFRRLQRRWPQQRRPGAQLVREVPTRF
HHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHE
LAFDVMNIEGEDITHWPYRERRELLDTLMVMESSPALTVPRHWTDVAPADMLAICADQHH
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHCCCC
EGIVCKRLDSPYRSGRSRDWIKCPVRATTEAVIVGAFAGHRGEVGTLVLAAHDEAGQLVL
CCEEEEECCCHHHCCCCCCEEECCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCEEE
LGQVGTGFSGAERRRLATLLAGTEVSAPPVAVGASMSGVQWFKPRYVGEVAYREYHAGKG
EECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
LRHASWKGLRSEPASGVCLPRDAGAAPG
CCCCCCCCCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
TRASLSPDRLVAPAPMLATLGPAPRGGQFAVEVKFDGQRGILTVDRRVQVTSRNGADIT
CCCCCCCCCEECCCCHHHHCCCCCCCCEEEEEEEECCCCCEEEECCEEEEECCCCCCHH
ETFPELSAVAAAVGGRRMVLDGEIVAVDEHGRPSFRRLQRRWPQQRRPGAQLVREVPTRF
HHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHE
LAFDVMNIEGEDITHWPYRERRELLDTLMVMESSPALTVPRHWTDVAPADMLAICADQHH
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHCCCC
EGIVCKRLDSPYRSGRSRDWIKCPVRATTEAVIVGAFAGHRGEVGTLVLAAHDEAGQLVL
CCEEEEECCCHHHCCCCCCEEECCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCEEE
LGQVGTGFSGAERRRLATLLAGTEVSAPPVAVGASMSGVQWFKPRYVGEVAYREYHAGKG
EECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
LRHASWKGLRSEPASGVCLPRDAGAAPG
CCCCCCCCCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]