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The map label for this gene is trxA [H]

Identifier: 119776348

GI number: 119776348

Start: 3808397

End: 3808723

Strand: Direct

Name: trxA [H]

Synonym: Sama_3216

Alternate gene names: 119776348

Gene position: 3808397-3808723 (Clockwise)

Preceding gene: 119776344

Following gene: 119776349

Centisome position: 88.44

GC content: 51.68

Gene sequence:

>327_bases
ATGAGCGACAAAATTGTAACCCTGAGCGACGACAGCTTTGAAAACGACGTACTGAAGTCTGAACTGCCAGTTCTGGTAGA
CTTCTGGGCAGAATGGTGCGGCCCTTGCAAAATGATCGCCCCAATTCTGGACGACGTAGCTGCCGAATACGAAGGTAAGG
TTACAGTTGCCAAGCTGAACGTTGACCACAACAACGCCTCTCCCGCCAAGTATGGCGTGCGTGGTATCCCAACGCTGCTG
ATGTTCAAAGGCGGCGAACTGGTTGCTACCAAGGTTGGCGCCTTGTCCAAGACTCAATTGAAAGAGTTCATCGACGCTCA
GCTCTAA

Upstream 100 bases:

>100_bases
AGCGACAACAAGTAGGTGGGCACTTGAATTCCTGTAAATCCGCCTCAATATACATGCTAAGCCATTCACAGACCAGCGAT
GGCATCATTTGGAGAACATC

Downstream 100 bases:

>100_bases
TCTTCGCCTGTTGGCGTGACGCCCGGCACAGCTTTTGGGCTAAAATGTGCCGGGCTGCCCTAAAAATCTGGACGCCTCCC
AGCTTAGGTGCTACTTTAAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIVTLSDDSFENDVLKSELPVLVDFWAEWCGPCKMIAPILDDVAAEYEGKVTVAKLNVDHNNASPAKYGVRGIPTLL
MFKGGELVATKVGALSKTQLKEFIDAQL

Sequences:

>Translated_108_residues
MSDKIVTLSDDSFENDVLKSELPVLVDFWAEWCGPCKMIAPILDDVAAEYEGKVTVAKLNVDHNNASPAKYGVRGIPTLL
MFKGGELVATKVGALSKTQLKEFIDAQL
>Mature_107_residues
SDKIVTLSDDSFENDVLKSELPVLVDFWAEWCGPCKMIAPILDDVAAEYEGKVTVAKLNVDHNNASPAKYGVRGIPTLLM
FKGGELVATKVGALSKTQLKEFIDAQL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=41.304347826087, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=34, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=72.2222222222222, Blast_Score=170, Evalue=2e-44,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=41.2371134020619, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=47.887323943662, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=111, Percent_Identity=34.2342342342342, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=111, Percent_Identity=34.2342342342342, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532254, Length=113, Percent_Identity=31.858407079646, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=31.858407079646, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=84, Percent_Identity=39.2857142857143, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=105, Percent_Identity=30.4761904761905, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=37, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=37.5, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=36.7816091954023, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=108, Percent_Identity=32.4074074074074, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=82, Percent_Identity=43.9024390243902, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=46.4788732394366, Blast_Score=68, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=42.5287356321839, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=36.9565217391304, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=38.6363636363636, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=36.046511627907, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=36.4705882352941, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=36.4705882352941, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11771; Mature: 11639

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIVTLSDDSFENDVLKSELPVLVDFWAEWCGPCKMIAPILDDVAAEYEGKVTVAKLN
CCCCEEEECCCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEE
VDHNNASPAKYGVRGIPTLLMFKGGELVATKVGALSKTQLKEFIDAQL
CCCCCCCCCCCCCCCCCEEEEECCCCEEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDKIVTLSDDSFENDVLKSELPVLVDFWAEWCGPCKMIAPILDDVAAEYEGKVTVAKLN
CCCEEEECCCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEE
VDHNNASPAKYGVRGIPTLLMFKGGELVATKVGALSKTQLKEFIDAQL
CCCCCCCCCCCCCCCCCEEEEECCCCEEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]