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The map label for this gene is tyrP [H]

Identifier: 119776071

GI number: 119776071

Start: 3493528

End: 3494715

Strand: Reverse

Name: tyrP [H]

Synonym: Sama_2939

Alternate gene names: 119776071

Gene position: 3494715-3493528 (Counterclockwise)

Preceding gene: 119776073

Following gene: 119776070

Centisome position: 81.16

GC content: 57.41

Gene sequence:

>1188_bases
GTGAATTTGAAAACACTTGGCTCTATCGCCATTGTGGCGGGTACCGCCATTGGGGCCGGCATGTTGGCGTTGCCGCTGGC
GACCGCCGCCCTTGGGGTGATCCCCGCGCTGTTATTGCTGCTGGTCGTGTGGGCCATTTCGGCATATACCTCCCTCCTTA
TGCTCGAAATTAACCTGCGCAGTGGCGTGGGTGACAATGTGCACGCCATCACCGGCAAGACACTGGGCAAAAAGGGGCAG
CTTATCCAGGGCGCCTCTTTCCTGAGTTTACTGTATGCCCTGACGGCTGCCTATCTGACCGGCGGCTCCTCCTTGCTGGT
ACACCGCATGGAGTCGGTATTTTCCATCAATCTCGATGGTCAGCTGGCGGTACTGCTTTTTACGCTGGTGCTTGGCAGCG
TGGCCGCATTGGGTGTGAGCTGGGTGGATAAGCTCTCCCGCTTGCTGTTCAGCTTGATGGTGGTGCTCCTGGTGCTGGTG
GTGGGCTTCCTGTTGCCTGAAATCCGCCCCTCTGTGATTGCCGCCGATGCCTTCGAAAAAGTGTCGGCCAATGCCTGGAT
GGCTGCTATTCCCGTCGTATTTACGTCTTTTGGTTTCCATGTGTGTATTGCCACATTGGTGCGCTACCTCGACGGTGATG
CGGTTAACCTGCGCAAGGTGCTGCTGATTGGCTCGACCATCCCACTGGTGTGTTACATCCTGTGGCTGCTGGTGACCCTG
GGAACCGTGGGTGGAGATGAAATTGCCACCTTCAACGGCGCCCTGCCCAAGCTTATCAGCGCCCTTCAGGAGCTGGCGGC
ACACCCCGTAGTGGGTCAGAGCATTGCGGTGTTTGCCGATCTGGCGCTGGTGACCTCCTTCCTTGGAGTAACCATGAGCC
TGTTTGATTTTCTGGCCGAAATGACCCGCTCAAAAGGCGGTATCGGTGGCCGTTTGCAGACCTGGATTATCACCTTTTTA
CCACCACTGCTGTGTGCGCTCTTTGTGCCCGAAGGCTTTGTGGCCGTGCTGGGTTTTGCCGCCATTCCGCTGGTGTTTAT
GATCATTTTCCTGCCGATTGCCATGGCACTGAATCAGCGTGCACAGTACCGGGACGGTTATCAGGTCAGCGGCGGCAAGC
TGGCCTTGTCGCTGATTGGTGTCGCAGGGGTGGCGATTATTGCCGCCCAGCTGTGGGTGGCACTGTAA

Upstream 100 bases:

>100_bases
GCGGGTGCGTCCTCTCAAGGCGATGGCCTTTCGGCAGTTCTAAAAATTGGCTCATACCTATAACTACAAATGATTTATCA
GACTTGAACAGGACAGTTCC

Downstream 100 bases:

>100_bases
AAAGCCTTTTGTAACGGAAGTTTGCCAAGGCTGTGACAGCTTGTAACCCTGTGGTAAAGTCGGGTCTTCGCGCCCGGCTT
TTTTGTACCCGCCGTTTGGG

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNLKTLGSIAIVAGTAIGAGMLALPLATAALGVIPALLLLLVVWAISAYTSLLMLEINLRSGVGDNVHAITGKTLGKKGQ
LIQGASFLSLLYALTAAYLTGGSSLLVHRMESVFSINLDGQLAVLLFTLVLGSVAALGVSWVDKLSRLLFSLMVVLLVLV
VGFLLPEIRPSVIAADAFEKVSANAWMAAIPVVFTSFGFHVCIATLVRYLDGDAVNLRKVLLIGSTIPLVCYILWLLVTL
GTVGGDEIATFNGALPKLISALQELAAHPVVGQSIAVFADLALVTSFLGVTMSLFDFLAEMTRSKGGIGGRLQTWIITFL
PPLLCALFVPEGFVAVLGFAAIPLVFMIIFLPIAMALNQRAQYRDGYQVSGGKLALSLIGVAGVAIIAAQLWVAL

Sequences:

>Translated_395_residues
MNLKTLGSIAIVAGTAIGAGMLALPLATAALGVIPALLLLLVVWAISAYTSLLMLEINLRSGVGDNVHAITGKTLGKKGQ
LIQGASFLSLLYALTAAYLTGGSSLLVHRMESVFSINLDGQLAVLLFTLVLGSVAALGVSWVDKLSRLLFSLMVVLLVLV
VGFLLPEIRPSVIAADAFEKVSANAWMAAIPVVFTSFGFHVCIATLVRYLDGDAVNLRKVLLIGSTIPLVCYILWLLVTL
GTVGGDEIATFNGALPKLISALQELAAHPVVGQSIAVFADLALVTSFLGVTMSLFDFLAEMTRSKGGIGGRLQTWIITFL
PPLLCALFVPEGFVAVLGFAAIPLVFMIIFLPIAMALNQRAQYRDGYQVSGGKLALSLIGVAGVAIIAAQLWVAL
>Mature_395_residues
MNLKTLGSIAIVAGTAIGAGMLALPLATAALGVIPALLLLLVVWAISAYTSLLMLEINLRSGVGDNVHAITGKTLGKKGQ
LIQGASFLSLLYALTAAYLTGGSSLLVHRMESVFSINLDGQLAVLLFTLVLGSVAALGVSWVDKLSRLLFSLMVVLLVLV
VGFLLPEIRPSVIAADAFEKVSANAWMAAIPVVFTSFGFHVCIATLVRYLDGDAVNLRKVLLIGSTIPLVCYILWLLVTL
GTVGGDEIATFNGALPKLISALQELAAHPVVGQSIAVFADLALVTSFLGVTMSLFDFLAEMTRSKGGIGGRLQTWIITFL
PPLLCALFVPEGFVAVLGFAAIPLVFMIIFLPIAMALNQRAQYRDGYQVSGGKLALSLIGVAGVAIIAAQLWVAL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=401, Percent_Identity=42.643391521197, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1790145, Length=387, Percent_Identity=27.6485788113695, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789552, Length=373, Percent_Identity=29.4906166219839, Blast_Score=154, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 41445; Mature: 41445

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKTLGSIAIVAGTAIGAGMLALPLATAALGVIPALLLLLVVWAISAYTSLLMLEINLR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
SGVGDNVHAITGKTLGKKGQLIQGASFLSLLYALTAAYLTGGSSLLVHRMESVFSINLDG
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCC
QLAVLLFTLVLGSVAALGVSWVDKLSRLLFSLMVVLLVLVVGFLLPEIRPSVIAADAFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VSANAWMAAIPVVFTSFGFHVCIATLVRYLDGDAVNLRKVLLIGSTIPLVCYILWLLVTL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
GTVGGDEIATFNGALPKLISALQELAAHPVVGQSIAVFADLALVTSFLGVTMSLFDFLAE
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTRSKGGIGGRLQTWIITFLPPLLCALFVPEGFVAVLGFAAIPLVFMIIFLPIAMALNQR
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQYRDGYQVSGGKLALSLIGVAGVAIIAAQLWVAL
HHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKTLGSIAIVAGTAIGAGMLALPLATAALGVIPALLLLLVVWAISAYTSLLMLEINLR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
SGVGDNVHAITGKTLGKKGQLIQGASFLSLLYALTAAYLTGGSSLLVHRMESVFSINLDG
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCC
QLAVLLFTLVLGSVAALGVSWVDKLSRLLFSLMVVLLVLVVGFLLPEIRPSVIAADAFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VSANAWMAAIPVVFTSFGFHVCIATLVRYLDGDAVNLRKVLLIGSTIPLVCYILWLLVTL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
GTVGGDEIATFNGALPKLISALQELAAHPVVGQSIAVFADLALVTSFLGVTMSLFDFLAE
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTRSKGGIGGRLQTWIITFLPPLLCALFVPEGFVAVLGFAAIPLVFMIIFLPIAMALNQR
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQYRDGYQVSGGKLALSLIGVAGVAIIAAQLWVAL
HHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]