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The map label for this gene is ung [H]

Identifier: 119775963

GI number: 119775963

Start: 3368450

End: 3369115

Strand: Reverse

Name: ung [H]

Synonym: Sama_2831

Alternate gene names: 119775963

Gene position: 3369115-3368450 (Counterclockwise)

Preceding gene: 119775965

Following gene: 119775961

Centisome position: 78.24

GC content: 54.65

Gene sequence:

>666_bases
ATGGCCGTTGCATGTTGGCAGGACTTTATTGCCGCCGAATCCGAGAAACCTTACTTTAAATCTCTCACTGAATTTGTTGC
CGCCGAACGCCAAAGTGGCAAAACCATTTTTCCTCCTGAAGCAGAAGTATTCGCGGCGTTTGAGCACACGCCATTGGATA
AGGTGCGGGTCGTGCTGATTGGCCAGGACCCATACCATGGTGCCGGGCAGGCCCATGGACTCTGTTTCTCGGTTAAGCCT
GGTATTAAGCCGCCGCCCTCGCTGGTGAATATGTATAAAGAGCTCTCAGCCGATATCCCCGACTTTGAGACACCGTCACA
CGGGTACTTACTGCCCTGGGCCAGACAGGGTGTGTTGATGCTCAACACCGTGCTCACGGTTGAGGAGGGCAAGGCACACT
CCCACGCCAAGGCGGGCTGGGAAACCTTTACAGCGGCCGCGCTTAAGCTGCTCAATGAGCGTGATACGCCGATTATCTTT
GTGCTTTGGGGCAGCCATGCCATCAAGAAGGGCAAGGGTATTACTGCGCCTCAGCATCAGGTGTTGTCGGGTGTGCACCC
ATCGCCCTTATCCGCCTATCGCGGCTTTTTTGGATGCGGCCACTTTTCGAAAATCAACGAGTTATTGAAAGCACATGGCG
GTGAGCCCATCGACTGGCGCCTGTAA

Upstream 100 bases:

>100_bases
TCTTGGTCGTGACGTGGCCGGAGCATCTGGCATGGAGGCTGATTTGCCATGGCCAATAAGATACACTCCTTTGCAGTGAA
TCATTCAGCCCGGGAGCCCC

Downstream 100 bases:

>100_bases
CGCTCGTTGTGTGGATAAACACAGCCCAATAAAAAACCTCGCCGATGCGAGGTTTTTTATTGGGTCTGGCAAGCTATCAG
TTGCTGCGGGATACGGCGAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAVACWQDFIAAESEKPYFKSLTEFVAAERQSGKTIFPPEAEVFAAFEHTPLDKVRVVLIGQDPYHGAGQAHGLCFSVKP
GIKPPPSLVNMYKELSADIPDFETPSHGYLLPWARQGVLMLNTVLTVEEGKAHSHAKAGWETFTAAALKLLNERDTPIIF
VLWGSHAIKKGKGITAPQHQVLSGVHPSPLSAYRGFFGCGHFSKINELLKAHGGEPIDWRL

Sequences:

>Translated_221_residues
MAVACWQDFIAAESEKPYFKSLTEFVAAERQSGKTIFPPEAEVFAAFEHTPLDKVRVVLIGQDPYHGAGQAHGLCFSVKP
GIKPPPSLVNMYKELSADIPDFETPSHGYLLPWARQGVLMLNTVLTVEEGKAHSHAKAGWETFTAAALKLLNERDTPIIF
VLWGSHAIKKGKGITAPQHQVLSGVHPSPLSAYRGFFGCGHFSKINELLKAHGGEPIDWRL
>Mature_220_residues
AVACWQDFIAAESEKPYFKSLTEFVAAERQSGKTIFPPEAEVFAAFEHTPLDKVRVVLIGQDPYHGAGQAHGLCFSVKPG
IKPPPSLVNMYKELSADIPDFETPSHGYLLPWARQGVLMLNTVLTVEEGKAHSHAKAGWETFTAAALKLLNERDTPIIFV
LWGSHAIKKGKGITAPQHQVLSGVHPSPLSAYRGFFGCGHFSKINELLKAHGGEPIDWRL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=54.4186046511628, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=54.1666666666667, Blast_Score=241, Evalue=3e-64,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=59.5348837209302, Blast_Score=273, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17556304, Length=215, Percent_Identity=48.3720930232558, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=47.6394849785408, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24254; Mature: 24123

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVACWQDFIAAESEKPYFKSLTEFVAAERQSGKTIFPPEAEVFAAFEHTPLDKVRVVLI
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCHHEEEECCCCCCCCEEEEEE
GQDPYHGAGQAHGLCFSVKPGIKPPPSLVNMYKELSADIPDFETPSHGYLLPWARQGVLM
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCEEE
LNTVLTVEEGKAHSHAKAGWETFTAAALKLLNERDTPIIFVLWGSHAIKKGKGITAPQHQ
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCCCCHHH
VLSGVHPSPLSAYRGFFGCGHFSKINELLKAHGGEPIDWRL
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AVACWQDFIAAESEKPYFKSLTEFVAAERQSGKTIFPPEAEVFAAFEHTPLDKVRVVLI
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCHHEEEECCCCCCCCEEEEEE
GQDPYHGAGQAHGLCFSVKPGIKPPPSLVNMYKELSADIPDFETPSHGYLLPWARQGVLM
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCEEE
LNTVLTVEEGKAHSHAKAGWETFTAAALKLLNERDTPIIFVLWGSHAIKKGKGITAPQHQ
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCCCCHHH
VLSGVHPSPLSAYRGFFGCGHFSKINELLKAHGGEPIDWRL
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]