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The map label for this gene is cueR [H]

Identifier: 119775865

GI number: 119775865

Start: 3266587

End: 3266994

Strand: Reverse

Name: cueR [H]

Synonym: Sama_2733

Alternate gene names: 119775865

Gene position: 3266994-3266587 (Counterclockwise)

Preceding gene: 119775866

Following gene: 119775864

Centisome position: 75.87

GC content: 56.86

Gene sequence:

>408_bases
ATGGGAGAAGGAGTGCAGATGTATATAGGTGAGGCGGCCAGGGTTACAGGACTTACCATCAAAGCCATCCGCTTTTACGA
GCAGAAAGGCTTATTGCCATCCCCTCAGCGTGATGGCCGCTATCGGGTCTATTCGCCTCAGCATCTCGAGCTGCTGCGCC
TTATTCGCGATGCCAAAGCCTTGGGTGTACCGCTGACCAAGCTCATGGCCGTCGTCCCAGCCAAGGGGGATACGCTCGAC
TGGCAGCAAATACGCCGCTTTCTCGAGGGCATTAAACAGGATATCCGGGCGCAGCAGCTCAGGCTAGAACAGCAACTGGC
GACGGTGGACGAGTGTCTGTCGGCCATAGACGATTGCCCGGGGCTTGGCGATTACGCCCTTGACTCTGCCCTTAAGAGGA
GACTTTAG

Upstream 100 bases:

>100_bases
CAAAATACCTCAGGCTGTCGTGCTATCCCGGCTGCGGAAATGACCCGTCGTCTTGCGGCAGGGGTGATGTTCTGAGTTTG
GGGACGCTGAGAGTGAATGC

Downstream 100 bases:

>100_bases
AATCGTCCCCGTTAACCTCGATAAGGAGTATGGGAATGAAAAATATTCTGATAGTAAACGCCAACCCAAAAGCCGACAGC
CTGTGCAAACATTTGGCGGA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MGEGVQMYIGEAARVTGLTIKAIRFYEQKGLLPSPQRDGRYRVYSPQHLELLRLIRDAKALGVPLTKLMAVVPAKGDTLD
WQQIRRFLEGIKQDIRAQQLRLEQQLATVDECLSAIDDCPGLGDYALDSALKRRL

Sequences:

>Translated_135_residues
MGEGVQMYIGEAARVTGLTIKAIRFYEQKGLLPSPQRDGRYRVYSPQHLELLRLIRDAKALGVPLTKLMAVVPAKGDTLD
WQQIRRFLEGIKQDIRAQQLRLEQQLATVDECLSAIDDCPGLGDYALDSALKRRL
>Mature_134_residues
GEGVQMYIGEAARVTGLTIKAIRFYEQKGLLPSPQRDGRYRVYSPQHLELLRLIRDAKALGVPLTKLMAVVPAKGDTLDW
QQIRRFLEGIKQDIRAQQLRLEQQLATVDECLSAIDDCPGLGDYALDSALKRRL

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=120, Percent_Identity=37.5, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15223; Mature: 15092

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEGVQMYIGEAARVTGLTIKAIRFYEQKGLLPSPQRDGRYRVYSPQHLELLRLIRDAKA
CCCCCEEHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LGVPLTKLMAVVPAKGDTLDWQQIRRFLEGIKQDIRAQQLRLEQQLATVDECLSAIDDCP
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLGDYALDSALKRRL
CCCHHHHHHHHHHCC
>Mature Secondary Structure 
GEGVQMYIGEAARVTGLTIKAIRFYEQKGLLPSPQRDGRYRVYSPQHLELLRLIRDAKA
CCCCEEHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LGVPLTKLMAVVPAKGDTLDWQQIRRFLEGIKQDIRAQQLRLEQQLATVDECLSAIDDCP
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLGDYALDSALKRRL
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 12147073 [H]