Click here to switch to the map view.

The map label for this gene is ubiH [H]

Identifier: 119775855

GI number: 119775855

Start: 3258150

End: 3259445

Strand: Reverse

Name: ubiH [H]

Synonym: Sama_2723

Alternate gene names: 119775855

Gene position: 3259445-3258150 (Counterclockwise)

Preceding gene: 119775856

Following gene: 119775854

Centisome position: 75.69

GC content: 59.34

Gene sequence:

>1296_bases
ATGGACGACACCCGTCACATCAACCCAACTGGCAGTGACAATGCGCCTGCCGATGTGTCGAATTCAGCGCAGGCGGTCGA
TATCGCTATCGTGGGCGGTGCCATGGCCGGTGCCACTCTGGCGCTCGCCCTCGAGCAGCTCTGCAAGCTATCAGACGCCC
CCCTTTCCATCGCCCTGATTGAAGCCAGGGCGCCCGGCGATGAACATCCCGGCTTTGATGCCCGCGCTATCGCCGTTGCC
GAAGGCTCCATTGAGGAGCTTAAGCGCCTCGGTGTGTGGCGACACCTGAGTCGGCTTGGCACCCCCATTACCGATATTCA
TGTCTCAGACCGTGGCCATTTTGGTATGACGGAGCTCAATAGCAGCGCCTTTGGTCTGCCTTATCTTGGGCAAGTGGTTG
AGCTTGAGGCCGTGGGCAAAGCATTGTTTGATGCCATGGCCAAGACCCGTATCCAACTGCTGTGCCCCGATAGTCTGGTG
GGTATGGAGGCGGGTCAGGATGCACACACCCTGCTGCTGGAGTCCGGTAAAAAGCTGAGTGCAAAGCTTGTCGTCGCTGC
CGATGGTTTGGGTTCTGCCGTACGCAGCCACTTTAACTTACCGCTTGAGCAGGTGGACTTTGATCAGGAAGCTGTGATTG
CCAATGTGGTAACCCGGCAGCCCCATGAACATTGGGCGTGGGAGCGCTTCACAGACACAGGGCCTTTGGCGCTGTTGCCC
ATGGCAGCTATTAATGGGGAACAGCGGCTCTCACTGGTGTGGGCCCTGCCTCCCGACGAAGCCCGAATGCTGCAGGACTG
CGATGAGCAACGCTTTGTGAGTCAATTACAGCAGGCCTTTGGCAACCGGGCCGGGGTCTTCCTTGGCGCCGGTAATCGTC
AGCGTTATCCCCTGAAACTGTCCTGGATGCCAAGACCCATTCACCATCGCTGCGTGTTTGTGGGCAATGCCGCTCAAACC
CTCCATCCCATCGCCGGTCAGGGCTTTAACCTGGGCCTCAGGGATATTGTCGATTTGACCCGGGTGTTGCAGCAGGCACT
CAGTGAAAACCGCCATGCAGATGTGGGCGATATTCGCCTGCTGCATCGTTATTTGACACTTCGCGAGCACGACAGGCGTG
AAACCCTGCTGGCCATCGAATCCCTGGTTCGGGGCTTTTCCAATCAATATTGGCCGCTGGTGGCCGGGCGCAGTGTGGGA
CTTCGGCTGCTGTCCTGGTGTCCGCCGCTCAAGGCGCCGCTTGCAAGCCGGGCCATGGGCTGGCGCCGTGGTGTCCGCCT
GACGCCCAACCTGTAA

Upstream 100 bases:

>100_bases
TCATTGTTATCAGGAATTTGGCCCCCAGGATGGCGGCGGCGCTATACAGCCCAGCAATAATCTGCATTGATATTGGCGGG
ACGTTGAGGAGCTAGGCACC

Downstream 100 bases:

>100_bases
CTATTTCGTCCGAGGACTGACAGATGATGACAACCCAAAGCTGTGATGTGGCCATTGTAGGTGGCGGCATGGTGGGATTG
GCAACCGCCATCGGCCTTGC

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MDDTRHINPTGSDNAPADVSNSAQAVDIAIVGGAMAGATLALALEQLCKLSDAPLSIALIEARAPGDEHPGFDARAIAVA
EGSIEELKRLGVWRHLSRLGTPITDIHVSDRGHFGMTELNSSAFGLPYLGQVVELEAVGKALFDAMAKTRIQLLCPDSLV
GMEAGQDAHTLLLESGKKLSAKLVVAADGLGSAVRSHFNLPLEQVDFDQEAVIANVVTRQPHEHWAWERFTDTGPLALLP
MAAINGEQRLSLVWALPPDEARMLQDCDEQRFVSQLQQAFGNRAGVFLGAGNRQRYPLKLSWMPRPIHHRCVFVGNAAQT
LHPIAGQGFNLGLRDIVDLTRVLQQALSENRHADVGDIRLLHRYLTLREHDRRETLLAIESLVRGFSNQYWPLVAGRSVG
LRLLSWCPPLKAPLASRAMGWRRGVRLTPNL

Sequences:

>Translated_431_residues
MDDTRHINPTGSDNAPADVSNSAQAVDIAIVGGAMAGATLALALEQLCKLSDAPLSIALIEARAPGDEHPGFDARAIAVA
EGSIEELKRLGVWRHLSRLGTPITDIHVSDRGHFGMTELNSSAFGLPYLGQVVELEAVGKALFDAMAKTRIQLLCPDSLV
GMEAGQDAHTLLLESGKKLSAKLVVAADGLGSAVRSHFNLPLEQVDFDQEAVIANVVTRQPHEHWAWERFTDTGPLALLP
MAAINGEQRLSLVWALPPDEARMLQDCDEQRFVSQLQQAFGNRAGVFLGAGNRQRYPLKLSWMPRPIHHRCVFVGNAAQT
LHPIAGQGFNLGLRDIVDLTRVLQQALSENRHADVGDIRLLHRYLTLREHDRRETLLAIESLVRGFSNQYWPLVAGRSVG
LRLLSWCPPLKAPLASRAMGWRRGVRLTPNL
>Mature_431_residues
MDDTRHINPTGSDNAPADVSNSAQAVDIAIVGGAMAGATLALALEQLCKLSDAPLSIALIEARAPGDEHPGFDARAIAVA
EGSIEELKRLGVWRHLSRLGTPITDIHVSDRGHFGMTELNSSAFGLPYLGQVVELEAVGKALFDAMAKTRIQLLCPDSLV
GMEAGQDAHTLLLESGKKLSAKLVVAADGLGSAVRSHFNLPLEQVDFDQEAVIANVVTRQPHEHWAWERFTDTGPLALLP
MAAINGEQRLSLVWALPPDEARMLQDCDEQRFVSQLQQAFGNRAGVFLGAGNRQRYPLKLSWMPRPIHHRCVFVGNAAQT
LHPIAGQGFNLGLRDIVDLTRVLQQALSENRHADVGDIRLLHRYLTLREHDRRETLLAIESLVRGFSNQYWPLVAGRSVG
LRLLSWCPPLKAPLASRAMGWRRGVRLTPNL

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=388, Percent_Identity=26.2886597938144, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI32967307, Length=275, Percent_Identity=29.8181818181818, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1789274, Length=398, Percent_Identity=46.2311557788945, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1789273, Length=401, Percent_Identity=33.4164588528678, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786883, Length=385, Percent_Identity=30.6493506493506, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25146631, Length=445, Percent_Identity=26.7415730337079, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321694, Length=463, Percent_Identity=23.5421166306695, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920760, Length=449, Percent_Identity=27.1714922048998, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 47137; Mature: 47137

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDTRHINPTGSDNAPADVSNSAQAVDIAIVGGAMAGATLALALEQLCKLSDAPLSIALI
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEE
EARAPGDEHPGFDARAIAVAEGSIEELKRLGVWRHLSRLGTPITDIHVSDRGHFGMTELN
EECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCC
SSAFGLPYLGQVVELEAVGKALFDAMAKTRIQLLCPDSLVGMEAGQDAHTLLLESGKKLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCCHHHHHHHCCCCCE
AKLVVAADGLGSAVRSHFNLPLEQVDFDQEAVIANVVTRQPHEHWAWERFTDTGPLALLP
EEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCCCHHHCHHHCCCCCCCHHHH
MAAINGEQRLSLVWALPPDEARMLQDCDEQRFVSQLQQAFGNRAGVFLGAGNRQRYPLKL
HHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEE
SWMPRPIHHRCVFVGNAAQTLHPIAGQGFNLGLRDIVDLTRVLQQALSENRHADVGDIRL
ECCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LHRYLTLREHDRRETLLAIESLVRGFSNQYWPLVAGRSVGLRLLSWCPPLKAPLASRAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHH
WRRGVRLTPNL
HHCCEEECCCC
>Mature Secondary Structure
MDDTRHINPTGSDNAPADVSNSAQAVDIAIVGGAMAGATLALALEQLCKLSDAPLSIALI
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEE
EARAPGDEHPGFDARAIAVAEGSIEELKRLGVWRHLSRLGTPITDIHVSDRGHFGMTELN
EECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCC
SSAFGLPYLGQVVELEAVGKALFDAMAKTRIQLLCPDSLVGMEAGQDAHTLLLESGKKLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCCHHHHHHHCCCCCE
AKLVVAADGLGSAVRSHFNLPLEQVDFDQEAVIANVVTRQPHEHWAWERFTDTGPLALLP
EEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHCCCCHHHCHHHCCCCCCCHHHH
MAAINGEQRLSLVWALPPDEARMLQDCDEQRFVSQLQQAFGNRAGVFLGAGNRQRYPLKL
HHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEE
SWMPRPIHHRCVFVGNAAQTLHPIAGQGFNLGLRDIVDLTRVLQQALSENRHADVGDIRL
ECCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LHRYLTLREHDRRETLLAIESLVRGFSNQYWPLVAGRSVGLRLLSWCPPLKAPLASRAMG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHH
WRRGVRLTPNL
HHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]