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The map label for this gene is lpxK

Identifier: 119774475

GI number: 119774475

Start: 1631534

End: 1632583

Strand: Direct

Name: lpxK

Synonym: Sama_1338

Alternate gene names: 119774475

Gene position: 1631534-1632583 (Clockwise)

Preceding gene: 119774474

Following gene: 119774476

Centisome position: 37.89

GC content: 58.0

Gene sequence:

>1050_bases
ATGCAAAGTTTTGTGCACAAAATCTGGTATCAGGGGCACCCGGCAGCCTGGCTGCTGTTGCCCCTGTCGCTGCTGTTTTG
GCTGGTCAGTAGTCTGCGCCGTGCGGCCTTCAGGTTGGGGCTTAAGCGCAGCGAGCGCTTACCTGTGCCCGTGGTGGTGG
TGGGTAATATCACCGCCGGTGGCAGCGGCAAAACCCCCACAGTGCTCTATCTTATTGAGCTGCTGCGCCGGGAAGGCTGG
CGCCCCGGCGTCATAAGCCGTGGCTATGGCGCCTCCTTTGACGGTGAGTTGGACGTAGTCGCAGGCATGTCACCCGCCCA
AGTGGGGGATGAGCCTGCCATGATAGCCATGCGCACCGGCATCCCTATGGTCGTGGGACGAAACCGTATCAAGGCTGCCC
ATAAGCTGCTGCAATGCCACGATGTAAACGTGATTCTGTGCGACGACGGCCTGCAGCATTACGCCCTCGAGCGGGATGTC
GAAATATTGGTGATTGATGGCGAACGCCGCTTTGGCAATGGCTGGCTGTTGCCTGCGGGGCCGCTGCGAGAAGGTGCATG
GCGTAAAAATTCGGTGAATTTTGTGCTCTGCAATGGCGCGAGCGCAGAAGCAGACGAATATGCCATGACCCTGGAACCAA
CTGGCCTTGTCGCGGTAGCCGCTATTCACGGCAAGTCTCAAGCCAAGGACAACAGCCACAATGCGCAGGATAATGCGACG
CCGCGCCCCGGGGATACCGTGAACGCCATGGCGGGCATTGGCAACCCACAGCGTTTTTTCTCGACCCTGATGGCTCAGGG
CTTTGTGCTTGAAAAGGCCCACGAATTTGCCGACCACATGGCCTTCAGTGAAACGGATATCGCCACCATCGACGATGGTC
GCCCACTGCTGATGACCGAAAAAGATGCGGTTAAATGTCGCGAATTTGCCAAACAACACTGGTGGTATCTCGCGGTTGAT
GCGAATCTACCGCCAACATTTTCAACCAGGCTGCTCGATGCCCTGAACCGGGCGGCCACAGCCAAGCAAGGAAACACCCA
TGGCCTTTGA

Upstream 100 bases:

>100_bases
TAGAGCAGGGACGTATTGTGGAGCGCGGCAACCACAAGTCACTGTTGGCGCAGGATGGTATGTACGCCAAACTCTATCAA
ATGCAGTTTACCGGCTGATT

Downstream 100 bases:

>100_bases
TAAAAAACTCCTGGAAATCGTTGCTTGCCCCGTGTGCAAGGGCAAGCTGGAATACGACAAGGCGGCAGAGCAGCTGATCT
GTAAGTTCGACCGACTGGCC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQSFVHKIWYQGHPAAWLLLPLSLLFWLVSSLRRAAFRLGLKRSERLPVPVVVVGNITAGGSGKTPTVLYLIELLRREGW
RPGVISRGYGASFDGELDVVAGMSPAQVGDEPAMIAMRTGIPMVVGRNRIKAAHKLLQCHDVNVILCDDGLQHYALERDV
EILVIDGERRFGNGWLLPAGPLREGAWRKNSVNFVLCNGASAEADEYAMTLEPTGLVAVAAIHGKSQAKDNSHNAQDNAT
PRPGDTVNAMAGIGNPQRFFSTLMAQGFVLEKAHEFADHMAFSETDIATIDDGRPLLMTEKDAVKCREFAKQHWWYLAVD
ANLPPTFSTRLLDALNRAATAKQGNTHGL

Sequences:

>Translated_349_residues
MQSFVHKIWYQGHPAAWLLLPLSLLFWLVSSLRRAAFRLGLKRSERLPVPVVVVGNITAGGSGKTPTVLYLIELLRREGW
RPGVISRGYGASFDGELDVVAGMSPAQVGDEPAMIAMRTGIPMVVGRNRIKAAHKLLQCHDVNVILCDDGLQHYALERDV
EILVIDGERRFGNGWLLPAGPLREGAWRKNSVNFVLCNGASAEADEYAMTLEPTGLVAVAAIHGKSQAKDNSHNAQDNAT
PRPGDTVNAMAGIGNPQRFFSTLMAQGFVLEKAHEFADHMAFSETDIATIDDGRPLLMTEKDAVKCREFAKQHWWYLAVD
ANLPPTFSTRLLDALNRAATAKQGNTHGL
>Mature_349_residues
MQSFVHKIWYQGHPAAWLLLPLSLLFWLVSSLRRAAFRLGLKRSERLPVPVVVVGNITAGGSGKTPTVLYLIELLRREGW
RPGVISRGYGASFDGELDVVAGMSPAQVGDEPAMIAMRTGIPMVVGRNRIKAAHKLLQCHDVNVILCDDGLQHYALERDV
EILVIDGERRFGNGWLLPAGPLREGAWRKNSVNFVLCNGASAEADEYAMTLEPTGLVAVAAIHGKSQAKDNSHNAQDNAT
PRPGDTVNAMAGIGNPQRFFSTLMAQGFVLEKAHEFADHMAFSETDIATIDDGRPLLMTEKDAVKCREFAKQHWWYLAVD
ANLPPTFSTRLLDALNRAATAKQGNTHGL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=340, Percent_Identity=47.0588235294118, Blast_Score=275, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SHEAM (A1S589)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927215.1
- STRING:   A1S589
- GeneID:   4603590
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1338
- NMPDR:   fig|326297.7.peg.1265
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   A1S589
- ProtClustDB:   PRK00652
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38227; Mature: 38227

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSFVHKIWYQGHPAAWLLLPLSLLFWLVSSLRRAAFRLGLKRSERLPVPVVVVGNITAG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEECC
GSGKTPTVLYLIELLRREGWRPGVISRGYGASFDGELDVVAGMSPAQVGDEPAMIAMRTG
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECC
IPMVVGRNRIKAAHKLLQCHDVNVILCDDGLQHYALERDVEILVIDGERRFGNGWLLPAG
CCEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEEECCCEECCEEECCCC
PLREGAWRKNSVNFVLCNGASAEADEYAMTLEPTGLVAVAAIHGKSQAKDNSHNAQDNAT
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCC
PRPGDTVNAMAGIGNPQRFFSTLMAQGFVLEKAHEFADHMAFSETDIATIDDGRPLLMTE
CCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEC
KDAVKCREFAKQHWWYLAVDANLPPTFSTRLLDALNRAATAKQGNTHGL
HHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQSFVHKIWYQGHPAAWLLLPLSLLFWLVSSLRRAAFRLGLKRSERLPVPVVVVGNITAG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEECC
GSGKTPTVLYLIELLRREGWRPGVISRGYGASFDGELDVVAGMSPAQVGDEPAMIAMRTG
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECC
IPMVVGRNRIKAAHKLLQCHDVNVILCDDGLQHYALERDVEILVIDGERRFGNGWLLPAG
CCEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEEECCCEECCEEECCCC
PLREGAWRKNSVNFVLCNGASAEADEYAMTLEPTGLVAVAAIHGKSQAKDNSHNAQDNAT
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCC
PRPGDTVNAMAGIGNPQRFFSTLMAQGFVLEKAHEFADHMAFSETDIATIDDGRPLLMTE
CCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEC
KDAVKCREFAKQHWWYLAVDANLPPTFSTRLLDALNRAATAKQGNTHGL
HHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA