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The map label for this gene is lolC [H]

Identifier: 119774469

GI number: 119774469

Start: 1623415

End: 1624650

Strand: Direct

Name: lolC [H]

Synonym: Sama_1332

Alternate gene names: 119774469

Gene position: 1623415-1624650 (Clockwise)

Preceding gene: 119774465

Following gene: 119774470

Centisome position: 37.7

GC content: 57.04

Gene sequence:

>1236_bases
ATGTTTTCTTCCTCTGCCTTTCTTATCGGATATCGCTACTGGCGGGCCCGCAAAGCCAATGCCTTTGCCTCCTTTATTAC
CCTGTTTGCCGTGAGTGGTATTTTCCTCGGAGTTGCCGCCCTGATTGTGGTCAGCTCAGTGATGAATGGCCTGGAAGGGC
AACTCAAAACGCGCATTCTTGGCGCCGTGCCCCAGGTGGTTGTTGAAAAAAACGATGGCTTCGCCGACTGGCGTCAAACG
GCCGACCAGCTGCAAGCAACGTTGCCGGGCATTGTGGGCGTAAGCCCATCCACAGGGACCCAGGCCATGTTGCAATCGAG
CAGCAACATCGGTGCCGTGCAGCTTTCCGGTATTCTGCCTGAGGTGGAGTCAGCCCTGGCGAGCCGAACTACCACTGTCT
ACTCTCCCGCCTTCGACAGCCTTATCAGCGGCGAATACCGGATAATCCTTGGGGTACAGCTCGCGTCAGAGCTGGATGTG
GCCGTGGGGGACACCATCCGGGTGCTCAGCGGCGAAGGCGTGGTGTTTTCACCTTTGGGGCCCGTACCCAGCCAGCGTAA
GTTTATCGTATCGGGGCTCTTTCAGATGGGGTCTCAGGTGGATGCCCAACTTGCTTTTATTCATTATGACGATGCCCGCC
GTCTGATGCGAAAAGCACCGGACAAGGTGGATGGCCTCAGATTGTATCTGGACGATCCCTTTGAGGCCGAAGCCACAGGC
AAGGCTGTGCCGCAGATATTGGCAGCTGAGGGCGATACGCTCAATGTTCATGACTGGCGCGACGGCTACGGCCACCTGTT
TGGTGCAGTCAAAATGGAAAAGAATATGACGTCGCTGATGCTCAGCCTGATAGTGGCGGTGGCAGCGTTTAACATAGTAT
CGGCGCTGGTGATGATGGTGGTGGATAAAACCACCGATGTGGCCGTACTGATGACCCAGGGACTGACCCGCAGTGCCGTG
ATGGGGATTTTTGTGACCCAGGGTTCCCTGAATGCCTTACTGGGACTGGTGCTTGGGCTGATTGCCGGTTTAGTACTGAC
GCTGAACCTGAATCCGCTGCTCAGCGCTCTGGGGATTGCTGTGCTGGGCGCAGGGCAGCCTCTGCCGGTGATAATCGCTG
CCGAGCAGCTCTGGCTGATAGTGATTGGCACTGTGGCCATAACTTTGCTGGCGACTCTGTACCCGGCACTCAGGGCGTCC
CGGGTGGAACCCGCTTCGGCGCTCAGATACGAATAA

Upstream 100 bases:

>100_bases
GGCTAACAAGGACATGCCTCTTTATTTATAGGTGAGATACCCCTATTATCGTGCCCACTCAAATAAATACGCAAGCATAG
CCAAGGCATCAGCAGCGCAC

Downstream 100 bases:

>100_bases
TTCAGGTACGAATAATTTATGCCCAAGGCATTCAGGCGCGTGGCGCCGGTGAGAGAGAATACAGATGCAAGACATACTGC
TTAAGGTCGAAAACGTCAGC

Product: lipoprotein releasing system transmembrane protein LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MFSSSAFLIGYRYWRARKANAFASFITLFAVSGIFLGVAALIVVSSVMNGLEGQLKTRILGAVPQVVVEKNDGFADWRQT
ADQLQATLPGIVGVSPSTGTQAMLQSSSNIGAVQLSGILPEVESALASRTTTVYSPAFDSLISGEYRIILGVQLASELDV
AVGDTIRVLSGEGVVFSPLGPVPSQRKFIVSGLFQMGSQVDAQLAFIHYDDARRLMRKAPDKVDGLRLYLDDPFEAEATG
KAVPQILAAEGDTLNVHDWRDGYGHLFGAVKMEKNMTSLMLSLIVAVAAFNIVSALVMMVVDKTTDVAVLMTQGLTRSAV
MGIFVTQGSLNALLGLVLGLIAGLVLTLNLNPLLSALGIAVLGAGQPLPVIIAAEQLWLIVIGTVAITLLATLYPALRAS
RVEPASALRYE

Sequences:

>Translated_411_residues
MFSSSAFLIGYRYWRARKANAFASFITLFAVSGIFLGVAALIVVSSVMNGLEGQLKTRILGAVPQVVVEKNDGFADWRQT
ADQLQATLPGIVGVSPSTGTQAMLQSSSNIGAVQLSGILPEVESALASRTTTVYSPAFDSLISGEYRIILGVQLASELDV
AVGDTIRVLSGEGVVFSPLGPVPSQRKFIVSGLFQMGSQVDAQLAFIHYDDARRLMRKAPDKVDGLRLYLDDPFEAEATG
KAVPQILAAEGDTLNVHDWRDGYGHLFGAVKMEKNMTSLMLSLIVAVAAFNIVSALVMMVVDKTTDVAVLMTQGLTRSAV
MGIFVTQGSLNALLGLVLGLIAGLVLTLNLNPLLSALGIAVLGAGQPLPVIIAAEQLWLIVIGTVAITLLATLYPALRAS
RVEPASALRYE
>Mature_411_residues
MFSSSAFLIGYRYWRARKANAFASFITLFAVSGIFLGVAALIVVSSVMNGLEGQLKTRILGAVPQVVVEKNDGFADWRQT
ADQLQATLPGIVGVSPSTGTQAMLQSSSNIGAVQLSGILPEVESALASRTTTVYSPAFDSLISGEYRIILGVQLASELDV
AVGDTIRVLSGEGVVFSPLGPVPSQRKFIVSGLFQMGSQVDAQLAFIHYDDARRLMRKAPDKVDGLRLYLDDPFEAEATG
KAVPQILAAEGDTLNVHDWRDGYGHLFGAVKMEKNMTSLMLSLIVAVAAFNIVSALVMMVVDKTTDVAVLMTQGLTRSAV
MGIFVTQGSLNALLGLVLGLIAGLVLTLNLNPLLSALGIAVLGAGQPLPVIIAAEQLWLIVIGTVAITLLATLYPALRAS
RVEPASALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=412, Percent_Identity=41.0194174757282, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1787362, Length=412, Percent_Identity=32.2815533980583, Blast_Score=177, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43550; Mature: 43550

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSSAFLIGYRYWRARKANAFASFITLFAVSGIFLGVAALIVVSSVMNGLEGQLKTRIL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVPQVVVEKNDGFADWRQTADQLQATLPGIVGVSPSTGTQAMLQSSSNIGAVQLSGILP
HHCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCCEEEECCCCH
EVESALASRTTTVYSPAFDSLISGEYRIILGVQLASELDVAVGDTIRVLSGEGVVFSPLG
HHHHHHHHCCCEEECHHHHHHHCCCEEEEEEEEHHHHCCHHCCCEEEEEECCCEEEECCC
PVPSQRKFIVSGLFQMGSQVDAQLAFIHYDDARRLMRKAPDKVDGLRLYLDDPFEAEATG
CCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
KAVPQILAAEGDTLNVHDWRDGYGHLFGAVKMEKNMTSLMLSLIVAVAAFNIVSALVMMV
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKTTDVAVLMTQGLTRSAVMGIFVTQGSLNALLGLVLGLIAGLVLTLNLNPLLSALGIA
HCCCCCEEHHHHCCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VLGAGQPLPVIIAAEQLWLIVIGTVAITLLATLYPALRASRVEPASALRYE
HCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCC
>Mature Secondary Structure
MFSSSAFLIGYRYWRARKANAFASFITLFAVSGIFLGVAALIVVSSVMNGLEGQLKTRIL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVPQVVVEKNDGFADWRQTADQLQATLPGIVGVSPSTGTQAMLQSSSNIGAVQLSGILP
HHCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCCEEEECCCCH
EVESALASRTTTVYSPAFDSLISGEYRIILGVQLASELDVAVGDTIRVLSGEGVVFSPLG
HHHHHHHHCCCEEECHHHHHHHCCCEEEEEEEEHHHHCCHHCCCEEEEEECCCEEEECCC
PVPSQRKFIVSGLFQMGSQVDAQLAFIHYDDARRLMRKAPDKVDGLRLYLDDPFEAEATG
CCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
KAVPQILAAEGDTLNVHDWRDGYGHLFGAVKMEKNMTSLMLSLIVAVAAFNIVSALVMMV
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKTTDVAVLMTQGLTRSAVMGIFVTQGSLNALLGLVLGLIAGLVLTLNLNPLLSALGIA
HCCCCCEEHHHHCCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VLGAGQPLPVIIAAEQLWLIVIGTVAITLLATLYPALRASRVEPASALRYE
HCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]