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The map label for this gene is apt

Identifier: 119774446

GI number: 119774446

Start: 1591486

End: 1592031

Strand: Direct

Name: apt

Synonym: Sama_1309

Alternate gene names: 119774446

Gene position: 1591486-1592031 (Clockwise)

Preceding gene: 119774445

Following gene: 119774447

Centisome position: 36.96

GC content: 52.56

Gene sequence:

>546_bases
ATGAACACAGATAGCTTAGCGCTTATCAAGCAAAGCATTAAAACCATTCCTGATTACCCCAAAGCCGGCATTATGTTCCG
TGATGTGACAAGCCTGCTTGAGGATCACACTGCTTACCAAACAGCTATGAAGCTGCTCGTTGAACGCTACAAGGATTCCG
GCTTCACTAAGGTCGTGGGAACCGAATCCCGCGGTTTCCTGTTCGGTGCACCGCTTGCGTTGGAGCTGGGTGTGGGTTTT
GTGCCTGTACGCAAGCCTGGCAAACTGCCCCGTGAAACCATCAGCGAAAGCTATGAGCTGGAATACGGACACGACACCCT
GGAAATCCACGTCGATGCTATCAAGGCTGGTGACAAGGTGTTGGTGATAGACGATCTGCTGGCCACCGGCGGTACTATCG
AAGCCACGGTTAAACTCATTCGCCGTCTGGGCGGTGATGTGGCCCACGCGGCCTTTGTTATTTCCCTGCCGGATCTGGGT
GGTGAAAAACGGTTGCAGGCCATGGGCCTGGAAATCTGTAAATTGTGTGAGTTCGAAGGCGATTAA

Upstream 100 bases:

>100_bases
GGAGCTTAAGCTTTAGCCGGATTAAATTTGAAGTCCACATTTCGTGGACTTTTTTGTTGTCAAAGTCCGGCGAAGCCGGC
AAATCTAACGTGAATGTCCT

Downstream 100 bases:

>100_bases
TCCAACGCTTGAACCCTTACACTTCCTGCCCCGTCATGGCGTTATGGCATCGCCCCCCTCAGCGTGGTATGTTTGCCCCA
TGACGGGACACAGGCTCCCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVGTESRGFLFGAPLALELGVGF
VPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKVLVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLG
GEKRLQAMGLEICKLCEFEGD

Sequences:

>Translated_181_residues
MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVGTESRGFLFGAPLALELGVGF
VPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKVLVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLG
GEKRLQAMGLEICKLCEFEGD
>Mature_181_residues
MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVGTESRGFLFGAPLALELGVGF
VPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKVLVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLG
GEKRLQAMGLEICKLCEFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=168, Percent_Identity=42.8571428571429, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=45.8646616541353, Blast_Score=120, Evalue=5e-28,
Organism=Escherichia coli, GI1786675, Length=179, Percent_Identity=73.1843575418994, Blast_Score=261, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=44.5121951219512, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=42.9447852760736, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=38.6503067484663, Blast_Score=94, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=46.3414634146341, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SHEAM (A1S560)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927186.1
- ProteinModelPortal:   A1S560
- SMR:   A1S560
- STRING:   A1S560
- GeneID:   4603561
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1309
- NMPDR:   fig|326297.7.peg.1236
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A1S560
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19723; Mature: 19723

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TESRGFLFGAPLALELGVGFVPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKV
CCCCCEEEECCHHEECCCCEEECCCCCCCCHHHHCCCEEEECCCCEEEEEEEEECCCCEE
LVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLGGEKRLQAMGLEICKLCEFEG
EEEEHHHHCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
D
C
>Mature Secondary Structure
MNTDSLALIKQSIKTIPDYPKAGIMFRDVTSLLEDHTAYQTAMKLLVERYKDSGFTKVVG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TESRGFLFGAPLALELGVGFVPVRKPGKLPRETISESYELEYGHDTLEIHVDAIKAGDKV
CCCCCEEEECCHHEECCCCEEECCCCCCCCHHHHCCCEEEECCCCEEEEEEEEECCCCEE
LVIDDLLATGGTIEATVKLIRRLGGDVAHAAFVISLPDLGGEKRLQAMGLEICKLCEFEG
EEEEHHHHCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA