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The map label for this gene is mutH

Identifier: 119773999

GI number: 119773999

Start: 1052366

End: 1053040

Strand: Reverse

Name: mutH

Synonym: Sama_0862

Alternate gene names: 119773999

Gene position: 1053040-1052366 (Counterclockwise)

Preceding gene: 119774010

Following gene: 119773998

Centisome position: 24.45

GC content: 56.89

Gene sequence:

>675_bases
ATGAACACTCCCCTCCCCCCTCAAAGTCTCGATGAATTGCTGCGCCGGGCCAAAATGATGGCAGGCCTTTCCCTTGGGCA
ACTCGCAGCAGGGCTGGGCTGGCCAGTCCCCGCAAACCTGAAGCGGGATAAGGGCTGGATAGGCCAGCTGATAGAGCAAG
AGCTGGGCGCCACCGCAGGCTCAAGACCCGAACAGGACTTTCTGCATCTGGGGGTGGAGCTCAAAACCATTCCCATCGAT
CGCAGCGGTAAGCCGTTGGAAACCACCTATGTGTGTGTTGCTCCCTTAATGGATACCCATGGGCTGCGTTGGGAGCAAAG
TCTGGTAAAGCACAAACTCGAGCGGGTACTTTGGGTTCCGGTGGAAGGCGAACGAGACATTCCGGTTGCCGACAGGCGCA
TAGGCACCGCTATTTTGTGGCAACCCACGCCACAACAGAGTGCATCGCTTCGCCAGGACTGGGAAGAAATCATGGAGTTC
ATCGCCCTGGGTAAGGTGCATCGCCTCAGCGCAAGACACGGTGAGGTGTTACAGCTTCGTCCCAAAGCGGCCAATGCTGC
TGCCAAAACCGAGTGCATTATGGAAGACGGCACCGTCGGACTGACCAATCCCCGAGGCTTTTATCTGAAGATCCCCTTCA
CTCAAGCCATACTGCGCCAGGCTTTTGACTACTAG

Upstream 100 bases:

>100_bases
AGTTAGTAGATACAACTATCAAAAAACTTATCCAAGTCGAAGATGAGGTCAAAAATGCAGCAATATTGATCTTATCCCCA
AAGTGGGTAGAATCCGCTCC

Downstream 100 bases:

>100_bases
CCGTCATCGAATCGACACCTGAATTGATTCAGATCACGTTAAGGGCTGGTAATGAGGCATAGGTTTTCTATACACTAGCT
CCTTCTTCGTAAAGGCTAAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAGSRPEQDFLHLGVELKTIPID
RSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVPVEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEF
IALGKVHRLSARHGEVLQLRPKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY

Sequences:

>Translated_224_residues
MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAGSRPEQDFLHLGVELKTIPID
RSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVPVEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEF
IALGKVHRLSARHGEVLQLRPKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY
>Mature_224_residues
MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAGSRPEQDFLHLGVELKTIPID
RSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVPVEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEF
IALGKVHRLSARHGEVLQLRPKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family

Homologues:

Organism=Escherichia coli, GI1789196, Length=217, Percent_Identity=59.9078341013825, Blast_Score=268, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTH_SHEAM (A1S3W3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926739.1
- ProteinModelPortal:   A1S3W3
- SMR:   A1S3W3
- STRING:   A1S3W3
- GeneID:   4603114
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0862
- NMPDR:   fig|326297.7.peg.813
- eggNOG:   COG3066
- HOGENOM:   HBG296591
- OMA:   QDWEELM
- PhylomeDB:   A1S3W3
- ProtClustDB:   PRK05070
- GO:   GO:0005737
- HAMAP:   MF_00759
- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335
- Gene3D:   G3DSA:3.40.600.10
- SMART:   SM00927
- TIGRFAMs:   TIGR02248

Pfam domain/function: PF02976 MutH; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 25029; Mature: 25029

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAG
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SRPEQDFLHLGVELKTIPIDRSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVP
CCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHEEEEE
VEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEFIALGKVHRLSARHGEVLQLR
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEC
PKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY
CCCCCHHHHHHHHHCCCCEECCCCCCEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAG
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SRPEQDFLHLGVELKTIPIDRSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVP
CCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHEEEEE
VEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEFIALGKVHRLSARHGEVLQLR
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEC
PKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY
CCCCCHHHHHHHHHCCCCEECCCCCCEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA