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The map label for this gene is cpxR [H]

Identifier: 119773770

GI number: 119773770

Start: 784754

End: 785461

Strand: Reverse

Name: cpxR [H]

Synonym: Sama_0632

Alternate gene names: 119773770

Gene position: 785461-784754 (Counterclockwise)

Preceding gene: 119773771

Following gene: 119773769

Centisome position: 18.24

GC content: 53.81

Gene sequence:

>708_bases
TTGGGATCTGCTGTAAAACACAAACTGCTGCTGATTGAAGACGACTTGCCCCTGGCAGAACTCATTGTGGATTTTCTCGA
GGCCGAGGAGTTCATTGTTATCCATGCCGAGTCCATCGAAGACGCCTTTACCAAAAGCCAGGGCCAGAACATAGAATTGG
TGCTCTGTGATGTGATGCTGCCCGGACAGGACGGCTTCAGCGCCTTTCCGACCTTGTCCAAAAAGGTTCCTGCACCCATT
ATTTTTATGACGGCACTGGCCGCACCGGAAGATGAAATCTTTGGTCTGGAGCTCGGTGCGGCCGACTATATCAGCAAGCC
CGTGGTGCCCAACCTGCTGCTTGCGCGCATCCGCGCCCGACTCAGTCGTCAGCCATCCCCCCAAAGTAACAGCCAAATTT
GGGAGCAGGATGGCCTCATCCTGCACAAGGCACATCAACAACTGTGCTTTGCAGATCAGAATTACCCGCTGACGACCCAG
GAAACCGAACTCTTGTGGGTCTTTGTGCACCATTTGGAGCAGGTATTAAGCCGCGAATTCCTGTTTGAGCAAATCATAGG
TCGCGAGTACGACGGCCTTGACCGGGCCATGGATCTGAAAATCTCCCGCCTGAGACGTAAGCTGGAAAACATCGGTATCC
CGGGTCTGGCCATTCGTACCGTGCACGGCCGGGGTTATCTGCTGAGCTTTGCGACTGACGAGATATGA

Upstream 100 bases:

>100_bases
CCATCGAAATCCGGGACATGAATTCCCGTGTACTGCTCTCAACCCAGGTGTCGGTGGTCTTGTTTCAACCACCGCAAAAA
CGCAAACGCAGGGGGCTGAA

Downstream 100 bases:

>100_bases
AGCCTCAGCTCATCCGGCTGTTTGTTCTTATCATTGCTTCCTGCGCCTTTATCGTTTGGTCCTTTAACCTTATTTACAGC
GCGTCCGACGAGGCATATGG

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MGSAVKHKLLLIEDDLPLAELIVDFLEAEEFIVIHAESIEDAFTKSQGQNIELVLCDVMLPGQDGFSAFPTLSKKVPAPI
IFMTALAAPEDEIFGLELGAADYISKPVVPNLLLARIRARLSRQPSPQSNSQIWEQDGLILHKAHQQLCFADQNYPLTTQ
ETELLWVFVHHLEQVLSREFLFEQIIGREYDGLDRAMDLKISRLRRKLENIGIPGLAIRTVHGRGYLLSFATDEI

Sequences:

>Translated_235_residues
MGSAVKHKLLLIEDDLPLAELIVDFLEAEEFIVIHAESIEDAFTKSQGQNIELVLCDVMLPGQDGFSAFPTLSKKVPAPI
IFMTALAAPEDEIFGLELGAADYISKPVVPNLLLARIRARLSRQPSPQSNSQIWEQDGLILHKAHQQLCFADQNYPLTTQ
ETELLWVFVHHLEQVLSREFLFEQIIGREYDGLDRAMDLKISRLRRKLENIGIPGLAIRTVHGRGYLLSFATDEI
>Mature_234_residues
GSAVKHKLLLIEDDLPLAELIVDFLEAEEFIVIHAESIEDAFTKSQGQNIELVLCDVMLPGQDGFSAFPTLSKKVPAPII
FMTALAAPEDEIFGLELGAADYISKPVVPNLLLARIRARLSRQPSPQSNSQIWEQDGLILHKAHQQLCFADQNYPLTTQE
TELLWVFVHHLEQVLSREFLFEQIIGREYDGLDRAMDLKISRLRRKLENIGIPGLAIRTVHGRGYLLSFATDEI

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=38.3620689655172, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=36.6379310344828, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.7777777777778, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=31.1965811965812, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=32.8828828828829, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=29.6803652968037, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=32.4444444444444, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=29.3333333333333, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=31.25, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=28.8288288288288, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=29.5652173913043, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786911, Length=203, Percent_Identity=25.1231527093596, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787375, Length=180, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26457; Mature: 26326

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAVKHKLLLIEDDLPLAELIVDFLEAEEFIVIHAESIEDAFTKSQGQNIELVLCDVML
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEEEEEEEE
PGQDGFSAFPTLSKKVPAPIIFMTALAAPEDEIFGLELGAADYISKPVVPNLLLARIRAR
CCCCCCCCCCCCHHCCCCCEEEEHHHCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHH
LSRQPSPQSNSQIWEQDGLILHKAHQQLCFADQNYPLTTQETELLWVFVHHLEQVLSREF
HCCCCCCCCCCCHHHHCCEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFEQIIGREYDGLDRAMDLKISRLRRKLENIGIPGLAIRTVHGRGYLLSFATDEI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC
>Mature Secondary Structure 
GSAVKHKLLLIEDDLPLAELIVDFLEAEEFIVIHAESIEDAFTKSQGQNIELVLCDVML
CCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEEEEEEEE
PGQDGFSAFPTLSKKVPAPIIFMTALAAPEDEIFGLELGAADYISKPVVPNLLLARIRAR
CCCCCCCCCCCCHHCCCCCEEEEHHHCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHH
LSRQPSPQSNSQIWEQDGLILHKAHQQLCFADQNYPLTTQETELLWVFVHHLEQVLSREF
HCCCCCCCCCCCHHHHCCEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFEQIIGREYDGLDRAMDLKISRLRRKLENIGIPGLAIRTVHGRGYLLSFATDEI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]