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The map label for this gene is murC

Identifier: 119773496

GI number: 119773496

Start: 425464

End: 426918

Strand: Direct

Name: murC

Synonym: Sama_0355

Alternate gene names: 119773496

Gene position: 425464-426918 (Clockwise)

Preceding gene: 119773495

Following gene: 119773497

Centisome position: 9.88

GC content: 58.14

Gene sequence:

>1455_bases
ATGACACAGACAGAGAAGTACAGACAGCTTCGTACCATGATCCCCGAGATGCGCCGCGTGCGCCGCATCCACTTTGTTGG
CATCGGCGGGGCCGGTATGGGCGGGATCGCCGAAGTACTGGTGAACGAAGGCTATCAGGTCAGCGGGTCGGACATTGCCG
ACAATGCCGTGACAGAGCGTCTGGGAAGTCTGGGTGCCCGTATTTTTATAGGTCATGGCGCCGATAACGTCAGTGGTGTG
GATGTAGTGGTGGTATCGACCGCCATCAAGCACGACAACCCTGAAATCGCTGCGGCCAAAGAGAAGCGTATTCCCATTGT
GCGCCGTGCAGAGATGCTTGCCGAGCTGATGCGTTATCGCCATGGCGTGGCCGTTGCCGGTACCCACGGTAAAACCACCA
CTACCAGTTTGATTGCCAGTATCTATGGGCAGGCCGAGCGTGACCCGACTTTTGTGATTGGTGGGCTGCTTAACAGTGCC
GGTACCAATGCCCGTCTGGGCTCAAGCCGTTATCTGATTGCCGAAGCCGACGAGAGTGATGCGAGCTTCCTGCACCTGCA
GCCAATGGTGACCGTGGTCACCAACATCGAAGCCGACCACATGGATACCTATGGCGGTGACTTCGAAAAGCTCAAGTCCA
CTTTCGTGGATTTTATGCACAATCTGCCGTTTTACGGTGTGGCCGTGGTCTGCGTGGACGACCCTGTGGTGCGCGAGCTT
ATCCCACGCATTGGCCGCCAGGTAGTGACTTATGGTTTCAGTGACGATGCCGACGTGCAGGCGCTGAACTTTGTACAGGA
AGGCCACAGCTGCCGCTTTACCGTGCGCCGCAAGGGCAAAGACGATCTGTCGCTCAAGGTCAATCTGCCGGGGCAGCACA
ATGTGCTTAACTCCCTGGCGGCCATTGCCGTGGCCACCGAGGATGACATTGAAGACGAGGCTATCGTCAAGGCGCTGGCC
GAATTCCAGGGCATTGGCCGCCGCTTCCAGCATCTGGGTAAGTTTGCGACCCCCAACGGTGAGGTCATGCTGGTGGATGA
CTACGGCCACCACCCCAGCGAAGTGCTTGCGACCATTAAAGCCGCCCGCGCCGGTTGGCCCGATAAGCGCCTTGTGATGG
CCTATCAGCCCCACAGGTACACACGTACCCGTGACCTGTACGAGGACTTCGTCGAGGTCTTGTCTCAGGTCGACAAGCTG
GTATTGCTGGAAGTGTACGCCGCGGGCGAAACGCCCATTCCCGGCGCTGATGGCCGCGCCTTATGCCGCTCAATCCGTCA
GCGTGGTCAGTTGGAACCGATTTTTGTGGCAAGCCCAGAGCAGCTGACATCAGTGCTGCCGGATGTGTTGGCCGATGGCG
ATCTACTGCTGTGTCAGGGCGCAGGCAATATAGGTGCCTTGTCCCGGGAGTTGGCGGCGACAGAGCTTGGATTTGCCAAG
GTGGAAAATAACTGA

Upstream 100 bases:

>100_bases
ATTGACCCGTATGGGTGAAAGGGCCAGGGCGGCGGCCGTACTGGATGCCACCGAACGTGTGGCAGAGGTTTGCCGCGAAC
TGGCGAAATAAAGGTTAGTT

Downstream 100 bases:

>100_bases
ATGCTGTTGAAAATTTCATCAGTTAAGTGGTTGTTCTCTTTGGCCTTTGACCTGAGATCCCGGGTCTATATAATGGCCGG
TTATTCTGTGGCTCGGCGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTQTEKYRQLRTMIPEMRRVRRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIADNAVTERLGSLGARIFIGHGADNVSGV
DVVVVSTAIKHDNPEIAAAKEKRIPIVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGQAERDPTFVIGGLLNSA
GTNARLGSSRYLIAEADESDASFLHLQPMVTVVTNIEADHMDTYGGDFEKLKSTFVDFMHNLPFYGVAVVCVDDPVVREL
IPRIGRQVVTYGFSDDADVQALNFVQEGHSCRFTVRRKGKDDLSLKVNLPGQHNVLNSLAAIAVATEDDIEDEAIVKALA
EFQGIGRRFQHLGKFATPNGEVMLVDDYGHHPSEVLATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDKL
VLLEVYAAGETPIPGADGRALCRSIRQRGQLEPIFVASPEQLTSVLPDVLADGDLLLCQGAGNIGALSRELAATELGFAK
VENN

Sequences:

>Translated_484_residues
MTQTEKYRQLRTMIPEMRRVRRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIADNAVTERLGSLGARIFIGHGADNVSGV
DVVVVSTAIKHDNPEIAAAKEKRIPIVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGQAERDPTFVIGGLLNSA
GTNARLGSSRYLIAEADESDASFLHLQPMVTVVTNIEADHMDTYGGDFEKLKSTFVDFMHNLPFYGVAVVCVDDPVVREL
IPRIGRQVVTYGFSDDADVQALNFVQEGHSCRFTVRRKGKDDLSLKVNLPGQHNVLNSLAAIAVATEDDIEDEAIVKALA
EFQGIGRRFQHLGKFATPNGEVMLVDDYGHHPSEVLATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDKL
VLLEVYAAGETPIPGADGRALCRSIRQRGQLEPIFVASPEQLTSVLPDVLADGDLLLCQGAGNIGALSRELAATELGFAK
VENN
>Mature_483_residues
TQTEKYRQLRTMIPEMRRVRRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIADNAVTERLGSLGARIFIGHGADNVSGVD
VVVVSTAIKHDNPEIAAAKEKRIPIVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGQAERDPTFVIGGLLNSAG
TNARLGSSRYLIAEADESDASFLHLQPMVTVVTNIEADHMDTYGGDFEKLKSTFVDFMHNLPFYGVAVVCVDDPVVRELI
PRIGRQVVTYGFSDDADVQALNFVQEGHSCRFTVRRKGKDDLSLKVNLPGQHNVLNSLAAIAVATEDDIEDEAIVKALAE
FQGIGRRFQHLGKFATPNGEVMLVDDYGHHPSEVLATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDKLV
LLEVYAAGETPIPGADGRALCRSIRQRGQLEPIFVASPEQLTSVLPDVLADGDLLLCQGAGNIGALSRELAATELGFAKV
ENN

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=64.9269311064718, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=29.3670886075949, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SHEAM (A1S2G0)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926236.1
- ProteinModelPortal:   A1S2G0
- SMR:   A1S2G0
- STRING:   A1S2G0
- GeneID:   4602611
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0355
- NMPDR:   fig|326297.7.peg.336
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1S2G0
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52707; Mature: 52575

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTEKYRQLRTMIPEMRRVRRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIADNAVTER
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCEECCCCHHHHHHHHH
LGSLGARIFIGHGADNVSGVDVVVVSTAIKHDNPEIAAAKEKRIPIVRRAEMLAELMRYR
HHCCCCEEEEECCCCCCCCCEEEEEEEHHHCCCCCEECCHHHCCCHHHHHHHHHHHHHHH
HGVAVAGTHGKTTTTSLIASIYGQAERDPTFVIGGLLNSAGTNARLGSSRYLIAEADESD
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVTVVTNIEADHMDTYGGDFEKLKSTFVDFMHNLPFYGVAVVCVDDPVVREL
CCEEEECHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
IPRIGRQVVTYGFSDDADVQALNFVQEGHSCRFTVRRKGKDDLSLKVNLPGQHNVLNSLA
HHHHCHHEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHH
AIAVATEDDIEDEAIVKALAEFQGIGRRFQHLGKFATPNGEVMLVDDYGHHPSEVLATIK
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDKLVLLEVYAAGETPIPGADGRA
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEHHEEECCCCCCCCCCHHH
LCRSIRQRGQLEPIFVASPEQLTSVLPDVLADGDLLLCQGAGNIGALSRELAATELGFAK
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEE
VENN
ECCC
>Mature Secondary Structure 
TQTEKYRQLRTMIPEMRRVRRIHFVGIGGAGMGGIAEVLVNEGYQVSGSDIADNAVTER
CCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCEECCCCHHHHHHHHH
LGSLGARIFIGHGADNVSGVDVVVVSTAIKHDNPEIAAAKEKRIPIVRRAEMLAELMRYR
HHCCCCEEEEECCCCCCCCCEEEEEEEHHHCCCCCEECCHHHCCCHHHHHHHHHHHHHHH
HGVAVAGTHGKTTTTSLIASIYGQAERDPTFVIGGLLNSAGTNARLGSSRYLIAEADESD
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCC
ASFLHLQPMVTVVTNIEADHMDTYGGDFEKLKSTFVDFMHNLPFYGVAVVCVDDPVVREL
CCEEEECHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
IPRIGRQVVTYGFSDDADVQALNFVQEGHSCRFTVRRKGKDDLSLKVNLPGQHNVLNSLA
HHHHCHHEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHH
AIAVATEDDIEDEAIVKALAEFQGIGRRFQHLGKFATPNGEVMLVDDYGHHPSEVLATIK
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHH
AARAGWPDKRLVMAYQPHRYTRTRDLYEDFVEVLSQVDKLVLLEVYAAGETPIPGADGRA
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEHHEEECCCCCCCCCCHHH
LCRSIRQRGQLEPIFVASPEQLTSVLPDVLADGDLLLCQGAGNIGALSRELAATELGFAK
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEE
VENN
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA