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The map label for this gene is cytR [H]

Identifier: 119773435

GI number: 119773435

Start: 352411

End: 353418

Strand: Direct

Name: cytR [H]

Synonym: Sama_0294

Alternate gene names: 119773435

Gene position: 352411-353418 (Clockwise)

Preceding gene: 119773428

Following gene: 119773436

Centisome position: 8.18

GC content: 52.88

Gene sequence:

>1008_bases
ATGACCAATATTAAGAAGGTAAGTGAACTGGCGGGTGTCTCCACCGCGACTGTTTCAAGGACGCTGAAAAGCCCGGAAAG
AGTCAGTGAGCAAACCCGTGCCAAGGTCATGCAGGCAGTAAAGCAAGCCGGATATCGTCCAAATTGGATGGCCACCAGTG
TTAAAACTGGCAAGTCCAATGCCATAGTGGTGTTGGTCCCCAACCTGGTTAACCCATTCTTTATGCGGATTATCGAAGGG
ATAGAGCAGGCGGCTCAGGAGAAAGGCTATTGCGTGCTGCTCGGCGACACCCAGGGGCTGCAGGCCCGGGAGCATGAGTA
TGCCAGCATGGTGCTCACCAACAGGGCCGATGGTCTTATTCAGCTGGACCATTCATTTCCTTTTTCTGATAACGATGCTG
ATCTGGCAGCCACAATCCCCATGGTCAGTGTCTGTGAACGTATCGAGGGGGATCGCAAATACCCCTTTATTGAGCTCGAC
AACCACGCCGCAGGCAGGGCCCTGGCCCATCATCTGATAGGCTTTGGACACAAACATTTCGGGATTATTGCCGGTCAGCG
CCGCAGCCAAATACACCATGATCGCCTGACGGGCATTATGAGTGTGCTTCAGGGTGAGGGTATTGATTTTAAAGAAGATA
TGCTGGTTGGTAGTAGCTACAGCATAGAGACGGGTATCGAAGGGGCGAGGGAGCTTCTCAGCCGAAATCCGCGCCCGAGC
GCGATTTTTTGCTTCAACGATGATATCGCCATCGGTGCTATGTTTGAAATCAAGTCCCAGGGGCTGAAGATCCCCGATGA
TATCTCTGTCACCGGCTTTGATAACGTCAAGGTGTCGGCTTATATGGACCCGCCTTTGACCACCATAGACCAGCCTGCCT
ACGAGATGGGACGCAATGCCGTTGAGGTATTGGTGCAACAAATCAACCGCCTTCCCCTGGCGCGCTCCCGGGTGATTATG
CCATTCCATTTATTGGAGCGTGGCAGCACGGGCCCCCTTAAAATTTAG

Upstream 100 bases:

>100_bases
AAATGCGAATTTGTTTTATGATTGTTACCGTAAAAAGTTAACTGCTTGCAATGATTTATCACAGGCCGGATGGCATATTC
ATCAGGAAATTCAATACTTA

Downstream 100 bases:

>100_bases
ATCTAATCTTCTGTCTTTAAAATAAAACATTAATTCTTTCATCCGCTTTCGGTGCGCGCGGCAGTAATATTTTATGCTGC
GCGGCACGTCATTTCTGTTA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTNIKKVSELAGVSTATVSRTLKSPERVSEQTRAKVMQAVKQAGYRPNWMATSVKTGKSNAIVVLVPNLVNPFFMRIIEG
IEQAAQEKGYCVLLGDTQGLQAREHEYASMVLTNRADGLIQLDHSFPFSDNDADLAATIPMVSVCERIEGDRKYPFIELD
NHAAGRALAHHLIGFGHKHFGIIAGQRRSQIHHDRLTGIMSVLQGEGIDFKEDMLVGSSYSIETGIEGARELLSRNPRPS
AIFCFNDDIAIGAMFEIKSQGLKIPDDISVTGFDNVKVSAYMDPPLTTIDQPAYEMGRNAVEVLVQQINRLPLARSRVIM
PFHLLERGSTGPLKI

Sequences:

>Translated_335_residues
MTNIKKVSELAGVSTATVSRTLKSPERVSEQTRAKVMQAVKQAGYRPNWMATSVKTGKSNAIVVLVPNLVNPFFMRIIEG
IEQAAQEKGYCVLLGDTQGLQAREHEYASMVLTNRADGLIQLDHSFPFSDNDADLAATIPMVSVCERIEGDRKYPFIELD
NHAAGRALAHHLIGFGHKHFGIIAGQRRSQIHHDRLTGIMSVLQGEGIDFKEDMLVGSSYSIETGIEGARELLSRNPRPS
AIFCFNDDIAIGAMFEIKSQGLKIPDDISVTGFDNVKVSAYMDPPLTTIDQPAYEMGRNAVEVLVQQINRLPLARSRVIM
PFHLLERGSTGPLKI
>Mature_334_residues
TNIKKVSELAGVSTATVSRTLKSPERVSEQTRAKVMQAVKQAGYRPNWMATSVKTGKSNAIVVLVPNLVNPFFMRIIEGI
EQAAQEKGYCVLLGDTQGLQAREHEYASMVLTNRADGLIQLDHSFPFSDNDADLAATIPMVSVCERIEGDRKYPFIELDN
HAAGRALAHHLIGFGHKHFGIIAGQRRSQIHHDRLTGIMSVLQGEGIDFKEDMLVGSSYSIETGIEGARELLSRNPRPSA
IFCFNDDIAIGAMFEIKSQGLKIPDDISVTGFDNVKVSAYMDPPLTTIDQPAYEMGRNAVEVLVQQINRLPLARSRVIMP
FHLLERGSTGPLKI

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=331, Percent_Identity=36.2537764350453, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=31.7220543806647, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787948, Length=343, Percent_Identity=32.6530612244898, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1788474, Length=307, Percent_Identity=31.5960912052117, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=30.7443365695793, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789202, Length=317, Percent_Identity=31.8611987381703, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789068, Length=300, Percent_Identity=30, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=28.0373831775701, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1790715, Length=306, Percent_Identity=26.1437908496732, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1787906, Length=336, Percent_Identity=27.0833333333333, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786540, Length=342, Percent_Identity=28.9473684210526, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789456, Length=343, Percent_Identity=24.7813411078717, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786268, Length=313, Percent_Identity=21.405750798722, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=20.440251572327, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36915; Mature: 36784

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIKKVSELAGVSTATVSRTLKSPERVSEQTRAKVMQAVKQAGYRPNWMATSVKTGKSN
CCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
AIVVLVPNLVNPFFMRIIEGIEQAAQEKGYCVLLGDTQGLQAREHEYASMVLTNRADGLI
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCCEE
QLDHSFPFSDNDADLAATIPMVSVCERIEGDRKYPFIELDNHAAGRALAHHLIGFGHKHF
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHH
GIIAGQRRSQIHHDRLTGIMSVLQGEGIDFKEDMLVGSSYSIETGIEGARELLSRNPRPS
EEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCCC
AIFCFNDDIAIGAMFEIKSQGLKIPDDISVTGFDNVKVSAYMDPPLTTIDQPAYEMGRNA
EEEEECCCEEEEEEEEEHHCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHHHCHHH
VEVLVQQINRLPLARSRVIMPFHLLERGSTGPLKI
HHHHHHHHHCCCCCCCCEECHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TNIKKVSELAGVSTATVSRTLKSPERVSEQTRAKVMQAVKQAGYRPNWMATSVKTGKSN
CCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
AIVVLVPNLVNPFFMRIIEGIEQAAQEKGYCVLLGDTQGLQAREHEYASMVLTNRADGLI
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCCEE
QLDHSFPFSDNDADLAATIPMVSVCERIEGDRKYPFIELDNHAAGRALAHHLIGFGHKHF
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHH
GIIAGQRRSQIHHDRLTGIMSVLQGEGIDFKEDMLVGSSYSIETGIEGARELLSRNPRPS
EEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCCC
AIFCFNDDIAIGAMFEIKSQGLKIPDDISVTGFDNVKVSAYMDPPLTTIDQPAYEMGRNA
EEEEECCCEEEEEEEEEHHCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHHHCHHH
VEVLVQQINRLPLARSRVIMPFHLLERGSTGPLKI
HHHHHHHHHCCCCCCCCEECHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]