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The map label for this gene is copA [H]

Identifier: 119717149

GI number: 119717149

Start: 3106450

End: 3108060

Strand: Reverse

Name: copA [H]

Synonym: Noca_2925

Alternate gene names: 119717149

Gene position: 3108060-3106450 (Counterclockwise)

Preceding gene: 119717150

Following gene: 119717146

Centisome position: 62.34

GC content: 70.02

Gene sequence:

>1611_bases
ATGACGGTCGACCGGCGAGATCAGGGGCGCGTGGCGAGCAGGGTCGGACGACGCAGCGTCCTCTTCGGGGCCGGCGGCCT
CGGGGTGCTCGCCGCCGGCGGGATCGGCATCCTCAAGGCGACCGGCGGGCCGTCCTCGGGGGACGCGGTCGACGCCGGCT
CTGCGGCGGTGCGTCGCGCAGAGGCGGAGCGCCGTCCGGCAGGCCAGCGAACGGTGACCGCCGACCTCCGGGTGCAGAGC
GCCACGGTGTCCCTCGGTGGCCTGGTGGTGCCCACCTGGGCGTACGGAGACTCCGTGCCCGGGCCGCTGATCCGGGCCAC
GGCGGGTGACCTGTTGAAGGTGAACGTCGACAACGCGCTCGGCTCGGAGACGAGTGTCCACTGGCACGGCATCGCGTTGC
GCAATGACATGGACGGCGTGCCCGGCATCACCCAGCGTCCCATCGCGGCGGGGTCGCGGTTCACCTATGAGTTCACCGTT
CCTGACCCCGGGACCTACTTCTACCACCCCCACACCGGCGTGCAGCTGGACCGCGGACTGTACGGCGTGCTCGTCGTCGA
CGACCCGGCCGAGCCGGGTGCCTACGACCAGGAGTGGGTCGTGGTGCTCGACGACTGGGTCGACGGCACCGGCACCACCC
CTGACGCAATCCTGGAGGAACTGCTGGCCACCACCGGGTCGTCCGGCATGGACGGCATGGACGGCATGGACGGCATGGAC
GGCATGGACGGCATGGACGGCATGGACGGCATGGACGGCATGGACGGCATGGAGGGGATGCACGGGATGCCGGGCATGGG
TGAAGCCATGCAATCGCCCCTGCTCGGCGGGGCGGGCGACGTCACCTACCCGCACTACCTCGTCAATGGTCGGACGCCCG
GGGCGCCGGCAACCTTGACTGGAGAGCCCGGGCAGCGAGTCCGGATCCGGATCATCAACGCCGGCTCCGACACCGCCTTC
CGGCTTGCGATCGGGGGACATCGGCTGACCGTCACCCACAGCGACGGCTTCCCGGTCCAGGAACAGGCCACGGACGCACT
GCTGATCGGGATGGGCGAGCGGTACGACGTCGTGGTCACCCTTGCCGACGGCGCCTTTCCGCTGGTCGCCTCCGCCGAGG
GCAAGGCGGGTCAGGGTCTCGCGGTGGTGCGGACCGGCAGCGGGCGGGCGCCACGCGGAGACGTCCGCGTTGCGGAGCTC
GACGGCCAGGTCCTGCTCGGCACCGACCTGGTTGCGACAGAGGCTTCCCGGCTGCCGAGCAGGGAGGTGGACCGGAGTAT
CGACCTCGTTCTCGGTGGCACCATGGCACCGTATCGATGGACGATCAACGGCGAGGTGTTCCCCGACGCACGCCCGCTGG
AGGTCGTCGAGGGCGAACGCATCCGGCTGCGCTTCGAGAACCGCACCATGATGTTCCACCCCATGCACCTGCACGGCCAT
ACCTATGGGCAGGTCCGCGGCGGCGCCCGCAAGGACACCACGATCGTGCGGCCGATGCAGACCGTCGAGGTCGACTTCGA
CGCCACGAACCCGGGGCAGTGGGCGGCACACTGCCACAACATCTATCACGCCGAGTCCGGAATGATGACGACCGTCTCCT
ACCGGACCTGA

Upstream 100 bases:

>100_bases
ACGATCCGCTGGCGATCCTGGACGGGCGATTCGCCCATGGCGAGATCGACGCGGCGGAGTACAGCGCTCGACGCGGCACG
CTGCTGGGCGCGGTTGATCG

Downstream 100 bases:

>100_bases
CGGCTTGCGCACGAGCTGCCGCGTAGCGATCCGAGCACGGATCCAGCGACCCGCCGGTCAGCTGATGAACCAACGTGGTC
GTGAAGCCGATCCCCAGGCG

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MTVDRRDQGRVASRVGRRSVLFGAGGLGVLAAGGIGILKATGGPSSGDAVDAGSAAVRRAEAERRPAGQRTVTADLRVQS
ATVSLGGLVVPTWAYGDSVPGPLIRATAGDLLKVNVDNALGSETSVHWHGIALRNDMDGVPGITQRPIAAGSRFTYEFTV
PDPGTYFYHPHTGVQLDRGLYGVLVVDDPAEPGAYDQEWVVVLDDWVDGTGTTPDAILEELLATTGSSGMDGMDGMDGMD
GMDGMDGMDGMDGMDGMEGMHGMPGMGEAMQSPLLGGAGDVTYPHYLVNGRTPGAPATLTGEPGQRVRIRIINAGSDTAF
RLAIGGHRLTVTHSDGFPVQEQATDALLIGMGERYDVVVTLADGAFPLVASAEGKAGQGLAVVRTGSGRAPRGDVRVAEL
DGQVLLGTDLVATEASRLPSREVDRSIDLVLGGTMAPYRWTINGEVFPDARPLEVVEGERIRLRFENRTMMFHPMHLHGH
TYGQVRGGARKDTTIVRPMQTVEVDFDATNPGQWAAHCHNIYHAESGMMTTVSYRT

Sequences:

>Translated_536_residues
MTVDRRDQGRVASRVGRRSVLFGAGGLGVLAAGGIGILKATGGPSSGDAVDAGSAAVRRAEAERRPAGQRTVTADLRVQS
ATVSLGGLVVPTWAYGDSVPGPLIRATAGDLLKVNVDNALGSETSVHWHGIALRNDMDGVPGITQRPIAAGSRFTYEFTV
PDPGTYFYHPHTGVQLDRGLYGVLVVDDPAEPGAYDQEWVVVLDDWVDGTGTTPDAILEELLATTGSSGMDGMDGMDGMD
GMDGMDGMDGMDGMDGMEGMHGMPGMGEAMQSPLLGGAGDVTYPHYLVNGRTPGAPATLTGEPGQRVRIRIINAGSDTAF
RLAIGGHRLTVTHSDGFPVQEQATDALLIGMGERYDVVVTLADGAFPLVASAEGKAGQGLAVVRTGSGRAPRGDVRVAEL
DGQVLLGTDLVATEASRLPSREVDRSIDLVLGGTMAPYRWTINGEVFPDARPLEVVEGERIRLRFENRTMMFHPMHLHGH
TYGQVRGGARKDTTIVRPMQTVEVDFDATNPGQWAAHCHNIYHAESGMMTTVSYRT
>Mature_535_residues
TVDRRDQGRVASRVGRRSVLFGAGGLGVLAAGGIGILKATGGPSSGDAVDAGSAAVRRAEAERRPAGQRTVTADLRVQSA
TVSLGGLVVPTWAYGDSVPGPLIRATAGDLLKVNVDNALGSETSVHWHGIALRNDMDGVPGITQRPIAAGSRFTYEFTVP
DPGTYFYHPHTGVQLDRGLYGVLVVDDPAEPGAYDQEWVVVLDDWVDGTGTTPDAILEELLATTGSSGMDGMDGMDGMDG
MDGMDGMDGMDGMDGMEGMHGMPGMGEAMQSPLLGGAGDVTYPHYLVNGRTPGAPATLTGEPGQRVRIRIINAGSDTAFR
LAIGGHRLTVTHSDGFPVQEQATDALLIGMGERYDVVVTLADGAFPLVASAEGKAGQGLAVVRTGSGRAPRGDVRVAELD
GQVLLGTDLVATEASRLPSREVDRSIDLVLGGTMAPYRWTINGEVFPDARPLEVVEGERIRLRFENRTMMFHPMHLHGHT
YGQVRGGARKDTTIVRPMQTVEVDFDATNPGQWAAHCHNIYHAESGMMTTVSYRT

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=162, Percent_Identity=30.8641975308642, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539950, Length=279, Percent_Identity=27.2401433691756, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320714, Length=504, Percent_Identity=21.2301587301587, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321067, Length=273, Percent_Identity=25.2747252747253, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323703, Length=114, Percent_Identity=39.4736842105263, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330000, Length=301, Percent_Identity=30.8970099667774, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585842, Length=308, Percent_Identity=30.5194805194805, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221329998, Length=301, Percent_Identity=30.8970099667774, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360167, Length=308, Percent_Identity=30.5194805194805, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574104, Length=125, Percent_Identity=43.2, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24650186, Length=343, Percent_Identity=24.198250728863, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859919, Length=119, Percent_Identity=42.0168067226891, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 56644; Mature: 56512

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDRRDQGRVASRVGRRSVLFGAGGLGVLAAGGIGILKATGGPSSGDAVDAGSAAVRRA
CCCCCCCCCHHHHHCCCCEEEEECCCHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHH
EAERRPAGQRTVTADLRVQSATVSLGGLVVPTWAYGDSVPGPLIRATAGDLLKVNVDNAL
HHHCCCCCCEEEEEEEEEEEEEEEECCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCC
GSETSVHWHGIALRNDMDGVPGITQRPIAAGSRFTYEFTVPDPGTYFYHPHTGVQLDRGL
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCCCCEECCCE
YGVLVVDDPAEPGAYDQEWVVVLDDWVDGTGTTPDAILEELLATTGSSGMDGMDGMDGMD
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDGMDGMDGMDGMDGMEGMHGMPGMGEAMQSPLLGGAGDVTYPHYLVNGRTPGAPATLT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEE
GEPGQRVRIRIINAGSDTAFRLAIGGHRLTVTHSDGFPVQEQATDALLIGMGERYDVVVT
CCCCCEEEEEEEECCCCCEEEEEECCEEEEEEECCCCCCHHHCCCEEEEECCCCEEEEEE
LADGAFPLVASAEGKAGQGLAVVRTGSGRAPRGDVRVAELDGQVLLGTDLVATEASRLPS
EECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCEEEHHHHHCCC
REVDRSIDLVLGGTMAPYRWTINGEVFPDARPLEVVEGERIRLRFENRTMMFHPMHLHGH
HHHCCEEEEEECCCCCCEEEEECCEECCCCCCEEEECCCEEEEEECCCEEEEEEEEECCC
TYGQVRGGARKDTTIVRPMQTVEVDFDATNPGQWAAHCHNIYHAESGMMTTVSYRT
CCEEECCCCCCCCEEECCEEEEEEEECCCCCCHHHHHHHHEEECCCCCEEEEEECC
>Mature Secondary Structure 
TVDRRDQGRVASRVGRRSVLFGAGGLGVLAAGGIGILKATGGPSSGDAVDAGSAAVRRA
CCCCCCCCHHHHHCCCCEEEEECCCHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHH
EAERRPAGQRTVTADLRVQSATVSLGGLVVPTWAYGDSVPGPLIRATAGDLLKVNVDNAL
HHHCCCCCCEEEEEEEEEEEEEEEECCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCC
GSETSVHWHGIALRNDMDGVPGITQRPIAAGSRFTYEFTVPDPGTYFYHPHTGVQLDRGL
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCCCCEECCCE
YGVLVVDDPAEPGAYDQEWVVVLDDWVDGTGTTPDAILEELLATTGSSGMDGMDGMDGMD
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDGMDGMDGMDGMDGMEGMHGMPGMGEAMQSPLLGGAGDVTYPHYLVNGRTPGAPATLT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEE
GEPGQRVRIRIINAGSDTAFRLAIGGHRLTVTHSDGFPVQEQATDALLIGMGERYDVVVT
CCCCCEEEEEEEECCCCCEEEEEECCEEEEEEECCCCCCHHHCCCEEEEECCCCEEEEEE
LADGAFPLVASAEGKAGQGLAVVRTGSGRAPRGDVRVAELDGQVLLGTDLVATEASRLPS
EECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCEEEHHHHHCCC
REVDRSIDLVLGGTMAPYRWTINGEVFPDARPLEVVEGERIRLRFENRTMMFHPMHLHGH
HHHCCEEEEEECCCCCCEEEEECCEECCCCCCEEEECCCEEEEEECCCEEEEEEEEECCC
TYGQVRGGARKDTTIVRPMQTVEVDFDATNPGQWAAHCHNIYHAESGMMTTVSYRT
CCEEECCCCCCCCEEECCEEEEEEEECCCCCCHHHHHHHHEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]