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The map label for this gene is hemH [H]

Identifier: 119717137

GI number: 119717137

Start: 3093357

End: 3094457

Strand: Reverse

Name: hemH [H]

Synonym: Noca_2913

Alternate gene names: 119717137

Gene position: 3094457-3093357 (Counterclockwise)

Preceding gene: 119717139

Following gene: 119717136

Centisome position: 62.06

GC content: 74.11

Gene sequence:

>1101_bases
ATGACCCCCGACCCCAGCCCGTACGACGCCGTCCTGCTGGTGTCCTTCGGCGGACCCGAACGCCCCGAGGACGTGGTGCC
GTTCCTCGAGAACGTGACCCGCGGCCGCGGCATCCCGCGCGAGCGGCTGGAGGAGGTCGGGCAGCACTACTACGAGTTCG
GTGGGCGGTCCCCGATCAACGACCAGAACCGGGCGTTCCTCGCCGCGCTGCGCGACGACCTCGCCGGCGCCGGGCTGGAC
CTCCCGGTCTACTGGGGCAACCGCAACTGGGACCCGCTCCTCGCCGACACGATCCGCGAGATGGCCGCCGACGGCATCAC
CCGCGCCGCGTGCTTCGTCACCAGCGCGTACGCGTCGTACTCCAGCTGCCGGCAGTACCGCGAGAACCTCTACGACGCGG
TCGCCGCCCTGGGGGAGGACCTCGAGGACGCGCCGGTGCTGGACAAGCTGCGGCACCCGTTCAACCACCCGGGCTTCGTC
GAGCCGATGGTCGACGCCACCCTCGCCGCGCTCGCGGACCTGCCCGAGCAGGTCCGCGAGGAGGCGCACCTGGTGTTCGT
GACCCACTCGCTGCCGGAGGCGATGAACGCCGCCAGCGGGCCGGAGGGCGGGGCCTACGTCGACCAGCACCTCAGCGTCG
CCGACGAGATCGTCGAGCGCGTACGCCAGGAGACCGGCCACCGGCATCGGCACGCGCTGGTGTACTGCTCGCGGTCCGGT
GCCCCGCACGTCCCGTGGCTCGAGCCGGACGTCAACGACCACCTCGAGCGGCTGCACCAGGACGGCGCGCCGGCGGTGGT
GCTGGTCCCGATCGGCTTCGTGTCCGACCACATGGAGGTGGTCTACGACCTCGACGTCGAGGCGATGCGCACGGCGGCCC
GGCTCGGCCTGCCCACCACCCGCGCGGCGACGGTGGGGATCGACCCGCGGTTCGTCGCGGCGGTGCGCGACCTGGTGCTC
GAGCGGGCCGCGGTCGAGCGGGGCGAGGACGTGGTGCGCGCCAGCGTCGGCCGCTGGCCGGCCTGCTGGGACCGGTGCCC
GGCGGGCTGCTGCGCGAACCCGCGCGCCGAGCGGCCGGCACTCGCGGGCGCCGACTCGTGA

Upstream 100 bases:

>100_bases
CCGCGAGGATCCGGCGGTAGGACGTGAGCATCGTCTCGAGCCTAGGGCTGGGGGACCGCCGCCCACGAATCGTTATCGGC
GGCTCCCTACGATGAGTCGC

Downstream 100 bases:

>100_bases
CCACCCTGCCGTCGCACGCTGAGCCGTCCAACGCTGGGCCGTCCAACGCCGACCTGGCCGACCTGGCGCTCGAGGTGGCG
CGGGAGGCGGCCGAGCTGGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTPDPSPYDAVLLVSFGGPERPEDVVPFLENVTRGRGIPRERLEEVGQHYYEFGGRSPINDQNRAFLAALRDDLAGAGLD
LPVYWGNRNWDPLLADTIREMAADGITRAACFVTSAYASYSSCRQYRENLYDAVAALGEDLEDAPVLDKLRHPFNHPGFV
EPMVDATLAALADLPEQVREEAHLVFVTHSLPEAMNAASGPEGGAYVDQHLSVADEIVERVRQETGHRHRHALVYCSRSG
APHVPWLEPDVNDHLERLHQDGAPAVVLVPIGFVSDHMEVVYDLDVEAMRTAARLGLPTTRAATVGIDPRFVAAVRDLVL
ERAAVERGEDVVRASVGRWPACWDRCPAGCCANPRAERPALAGADS

Sequences:

>Translated_366_residues
MTPDPSPYDAVLLVSFGGPERPEDVVPFLENVTRGRGIPRERLEEVGQHYYEFGGRSPINDQNRAFLAALRDDLAGAGLD
LPVYWGNRNWDPLLADTIREMAADGITRAACFVTSAYASYSSCRQYRENLYDAVAALGEDLEDAPVLDKLRHPFNHPGFV
EPMVDATLAALADLPEQVREEAHLVFVTHSLPEAMNAASGPEGGAYVDQHLSVADEIVERVRQETGHRHRHALVYCSRSG
APHVPWLEPDVNDHLERLHQDGAPAVVLVPIGFVSDHMEVVYDLDVEAMRTAARLGLPTTRAATVGIDPRFVAAVRDLVL
ERAAVERGEDVVRASVGRWPACWDRCPAGCCANPRAERPALAGADS
>Mature_365_residues
TPDPSPYDAVLLVSFGGPERPEDVVPFLENVTRGRGIPRERLEEVGQHYYEFGGRSPINDQNRAFLAALRDDLAGAGLDL
PVYWGNRNWDPLLADTIREMAADGITRAACFVTSAYASYSSCRQYRENLYDAVAALGEDLEDAPVLDKLRHPFNHPGFVE
PMVDATLAALADLPEQVREEAHLVFVTHSLPEAMNAASGPEGGAYVDQHLSVADEIVERVRQETGHRHRHALVYCSRSGA
PHVPWLEPDVNDHLERLHQDGAPAVVLVPIGFVSDHMEVVYDLDVEAMRTAARLGLPTTRAATVGIDPRFVAAVRDLVLE
RAAVERGEDVVRASVGRWPACWDRCPAGCCANPRAERPALAGADS

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=335, Percent_Identity=27.1641791044776, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI60499025, Length=335, Percent_Identity=27.1641791044776, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324750, Length=331, Percent_Identity=24.4712990936556, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17864156, Length=378, Percent_Identity=25.9259259259259, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45552018, Length=205, Percent_Identity=28.2926829268293, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40109; Mature: 39978

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDPSPYDAVLLVSFGGPERPEDVVPFLENVTRGRGIPRERLEEVGQHYYEFGGRSPIN
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
DQNRAFLAALRDDLAGAGLDLPVYWGNRNWDPLLADTIREMAADGITRAACFVTSAYASY
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SSCRQYRENLYDAVAALGEDLEDAPVLDKLRHPFNHPGFVEPMVDATLAALADLPEQVRE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAHLVFVTHSLPEAMNAASGPEGGAYVDQHLSVADEIVERVRQETGHRHRHALVYCSRSG
CCEEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
APHVPWLEPDVNDHLERLHQDGAPAVVLVPIGFVSDHMEVVYDLDVEAMRTAARLGLPTT
CCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RAATVGIDPRFVAAVRDLVLERAAVERGEDVVRASVGRWPACWDRCPAGCCANPRAERPA
CCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCC
LAGADS
CCCCCC
>Mature Secondary Structure 
TPDPSPYDAVLLVSFGGPERPEDVVPFLENVTRGRGIPRERLEEVGQHYYEFGGRSPIN
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
DQNRAFLAALRDDLAGAGLDLPVYWGNRNWDPLLADTIREMAADGITRAACFVTSAYASY
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SSCRQYRENLYDAVAALGEDLEDAPVLDKLRHPFNHPGFVEPMVDATLAALADLPEQVRE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAHLVFVTHSLPEAMNAASGPEGGAYVDQHLSVADEIVERVRQETGHRHRHALVYCSRSG
CCEEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
APHVPWLEPDVNDHLERLHQDGAPAVVLVPIGFVSDHMEVVYDLDVEAMRTAARLGLPTT
CCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RAATVGIDPRFVAAVRDLVLERAAVERGEDVVRASVGRWPACWDRCPAGCCANPRAERPA
CCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCC
LAGADS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA