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The map label for this gene is cobD [H]

Identifier: 119717109

GI number: 119717109

Start: 3066622

End: 3067497

Strand: Reverse

Name: cobD [H]

Synonym: Noca_2885

Alternate gene names: 119717109

Gene position: 3067497-3066622 (Counterclockwise)

Preceding gene: 119717110

Following gene: 119717108

Centisome position: 61.52

GC content: 72.6

Gene sequence:

>876_bases
ATGCTCGGCGACCCCGCACACCGCCATCCCGTCGCCGGTTTCGGCCACGTCGCGCGCGCGGTCGAGGAGAGCGTGTACGG
CGACTCCCGCGCGCGCGGTGTGCTTCATGCCGCCGTACTGGTCGGTGGAGCCGGGGTCCTCGGCGTCGTCGCCGAGAAGG
CTGCTCGCACGCCGATCGCTCGATCAGCGGTAACCGCCGTCGTGACGTGGGCCGTGCTGGGTGGGCGGACGCTGGAACGT
GAAGCATCCGCCGTCCACGTCCTGCTGGCCGCCGGCGACCTGCCGGGGGCACGGGTCCAGGTGAAGCGGCTCGTCGGTCG
CGACACGGAGCGGCTCGACGAGTCCGAGGTCGCGCGGGCCGTCGTGGAGTCGGTCGCCGAGAACAGCTCCGACGCCGTCG
TCGCCCCGCTCGTATGGGGCGCACTGCTGGGCCCTGCAGGCCTACTGGGCTATCGCGCTGCGAACACCCTCGACGCGATG
GTGGGCCACCACAACATGCGCTACGAGAACTTCGGGTGGGCCAGCGCGCGGCTCGACGACCTCGTGAATCTCCCGGGGGC
ACGACTAGCCGGGCTCCTCACCGTGGCGCTGGGTGGAAACCCCCGCAGGGCGATCACCGACTGGCGTCGCGACGCGGCTG
CCCACCCCAGCCCCAACGCCGGAGTCGTCGAGTCGACCTTCGCGGGGTCGCTCGGGATCCGTCTCGGTGGCACGAACACC
TACGACGGCGACCGGGTCGAGCACCGCGCCGTGATGGGCGACGGGCGCGCGGTCGAGCCTCGTGACATCGCAACCGCCGT
TCGGCTCGGCGCGCGTGTCGGGGCGGGCGCGGCTCTCGTGGCGGCCGCAGTCGCCGTACTCCGGAGATCGCGATGA

Upstream 100 bases:

>100_bases
GCGCTCCTCAGCAGCGTGGCGCTGCTCGAGGAGCTCACGACCTGATGCGGCCATGAAGGCGCGTGCCGCCGGGCTCCTGC
TCGGCTACGCAGCCGACCGG

Downstream 100 bases:

>100_bases
GCGTCGTGCTCGTCGGCATGTCCGTCAGCGACGTCGATCGTCGTGACCATCTGTTCACGTGCGCGCGGCCCTTGGGCGGC
ACCGTCGCGTTCCTGCAGAT

Product: adenosylcobinamide-phosphate synthase

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLGDPAHRHPVAGFGHVARAVEESVYGDSRARGVLHAAVLVGGAGVLGVVAEKAARTPIARSAVTAVVTWAVLGGRTLER
EASAVHVLLAAGDLPGARVQVKRLVGRDTERLDESEVARAVVESVAENSSDAVVAPLVWGALLGPAGLLGYRAANTLDAM
VGHHNMRYENFGWASARLDDLVNLPGARLAGLLTVALGGNPRRAITDWRRDAAAHPSPNAGVVESTFAGSLGIRLGGTNT
YDGDRVEHRAVMGDGRAVEPRDIATAVRLGARVGAGAALVAAAVAVLRRSR

Sequences:

>Translated_291_residues
MLGDPAHRHPVAGFGHVARAVEESVYGDSRARGVLHAAVLVGGAGVLGVVAEKAARTPIARSAVTAVVTWAVLGGRTLER
EASAVHVLLAAGDLPGARVQVKRLVGRDTERLDESEVARAVVESVAENSSDAVVAPLVWGALLGPAGLLGYRAANTLDAM
VGHHNMRYENFGWASARLDDLVNLPGARLAGLLTVALGGNPRRAITDWRRDAAAHPSPNAGVVESTFAGSLGIRLGGTNT
YDGDRVEHRAVMGDGRAVEPRDIATAVRLGARVGAGAALVAAAVAVLRRSR
>Mature_291_residues
MLGDPAHRHPVAGFGHVARAVEESVYGDSRARGVLHAAVLVGGAGVLGVVAEKAARTPIARSAVTAVVTWAVLGGRTLER
EASAVHVLLAAGDLPGARVQVKRLVGRDTERLDESEVARAVVESVAENSSDAVVAPLVWGALLGPAGLLGYRAANTLDAM
VGHHNMRYENFGWASARLDDLVNLPGARLAGLLTVALGGNPRRAITDWRRDAAAHPSPNAGVVESTFAGSLGIRLGGTNT
YDGDRVEHRAVMGDGRAVEPRDIATAVRLGARVGAGAALVAAAVAVLRRSR

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 30068; Mature: 30068

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGDPAHRHPVAGFGHVARAVEESVYGDSRARGVLHAAVLVGGAGVLGVVAEKAARTPIA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHH
RSAVTAVVTWAVLGGRTLEREASAVHVLLAAGDLPGARVQVKRLVGRDTERLDESEVARA
HHHHHHHHHHHHHCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCHHHCCHHHHHHH
VVESVAENSSDAVVAPLVWGALLGPAGLLGYRAANTLDAMVGHHNMRYENFGWASARLDD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LVNLPGARLAGLLTVALGGNPRRAITDWRRDAAAHPSPNAGVVESTFAGSLGIRLGGTNT
HHCCCCHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEECCCCC
YDGDRVEHRAVMGDGRAVEPRDIATAVRLGARVGAGAALVAAAVAVLRRSR
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLGDPAHRHPVAGFGHVARAVEESVYGDSRARGVLHAAVLVGGAGVLGVVAEKAARTPIA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHH
RSAVTAVVTWAVLGGRTLEREASAVHVLLAAGDLPGARVQVKRLVGRDTERLDESEVARA
HHHHHHHHHHHHHCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCHHHCCHHHHHHH
VVESVAENSSDAVVAPLVWGALLGPAGLLGYRAANTLDAMVGHHNMRYENFGWASARLDD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LVNLPGARLAGLLTVALGGNPRRAITDWRRDAAAHPSPNAGVVESTFAGSLGIRLGGTNT
HHCCCCHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEECCCCC
YDGDRVEHRAVMGDGRAVEPRDIATAVRLGARVGAGAALVAAAVAVLRRSR
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]