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The map label for this gene is cobS

Identifier: 119716737

GI number: 119716737

Start: 2678400

End: 2679089

Strand: Reverse

Name: cobS

Synonym: Noca_2511

Alternate gene names: 119716737

Gene position: 2679089-2678400 (Counterclockwise)

Preceding gene: 119716738

Following gene: 119716730

Centisome position: 53.73

GC content: 78.7

Gene sequence:

>690_bases
ATGCGTGACGCCTGGCGGTTCGCGGTCGGGACCCTGACCGCCCTGCCGGTGCGCCCACCGACGCGGGTGGACCGGGACAC
GGCTCGTCGCGCGATGCTGCTGGCCCCCCTCGCGGCGCTCCCCCTCGGGCTGCTCGTCGCGGCGGTCCTGGCCGCCGGGC
GGGCGGTCGAGCTGCCGCCACTCGCCGTGGGCCTGCTGGCGGTCGGTGCCCTGGCCGCGAGCTCGCGCGCGCTGCACTGG
GACGGGCTCTCCGACACGGTGGACGGCCTCGCGGCGTCGTACGACCCGGCCCGCTCCCTCGCCGTGATGCGGTCGGGCAC
CAGCGGTCCGGCCGGCGTCCTGGCGACCGTGGTCGTGGCCGGGGTGCAGGCGGCCGCCCTCGCGACGCTGCTGGACCAGC
CCCTCCTGGCGGGCGCGCTGGTCTGCCTGTCCCGGTGCGCGCTCTGGATCGTGTGCTGCACGCGGGTGCCGGCGGCGCGC
GCGGACGGCCTCGGCGCCGACGTCGCGCGCACCGTCCCCCTGCCGGTCGCGGTCCTCGGCGGCCTGCTGCTGTCGGCGGT
CGGCGGGCTGGTCGTGCTGGTGCTCGTCCGCCGCACCGTACGACGGTTCGGCGGCGTCACCGGCGACGTCATGGGTGCCG
CGGTCGAGCTGGCGCTCGCGGCCACGCTGCTCGCCTGGGCGGCGCGCTAA

Upstream 100 bases:

>100_bases
GGGCTGCGGCTCGGCGAGGGCAGCGGTGCGGTCGCGGCAGTGCCGGTGCTGCGCAGTGCGGTCGCCCTGCTGCGCGACGT
GGGCCTGCTCAGCGAGCTCG

Downstream 100 bases:

>100_bases
CGCCGCGTCCCAGAAGTTCTTGGGCGCTTCGCGCCCACATGGCACGCACCTCGCTGCGTTGCCGACGCTTGCGAGACGAG
TGGGTATGGCGGCGCGCCGG

Product: cobalamin-5'-phosphate synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRDAWRFAVGTLTALPVRPPTRVDRDTARRAMLLAPLAALPLGLLVAAVLAAGRAVELPPLAVGLLAVGALAASSRALHW
DGLSDTVDGLAASYDPARSLAVMRSGTSGPAGVLATVVVAGVQAAALATLLDQPLLAGALVCLSRCALWIVCCTRVPAAR
ADGLGADVARTVPLPVAVLGGLLLSAVGGLVVLVLVRRTVRRFGGVTGDVMGAAVELALAATLLAWAAR

Sequences:

>Translated_229_residues
MRDAWRFAVGTLTALPVRPPTRVDRDTARRAMLLAPLAALPLGLLVAAVLAAGRAVELPPLAVGLLAVGALAASSRALHW
DGLSDTVDGLAASYDPARSLAVMRSGTSGPAGVLATVVVAGVQAAALATLLDQPLLAGALVCLSRCALWIVCCTRVPAAR
ADGLGADVARTVPLPVAVLGGLLLSAVGGLVVLVLVRRTVRRFGGVTGDVMGAAVELALAATLLAWAAR
>Mature_229_residues
MRDAWRFAVGTLTALPVRPPTRVDRDTARRAMLLAPLAALPLGLLVAAVLAAGRAVELPPLAVGLLAVGALAASSRALHW
DGLSDTVDGLAASYDPARSLAVMRSGTSGPAGVLATVVVAGVQAAALATLLDQPLLAGALVCLSRCALWIVCCTRVPAAR
ADGLGADVARTVPLPVAVLGGLLLSAVGGLVVLVLVRRTVRRFGGVTGDVMGAAVELALAATLLAWAAR

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin)

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBS_NOCSJ (A1SJN0)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923702.1
- STRING:   A1SJN0
- GeneID:   4597842
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2511
- eggNOG:   COG0368
- HOGENOM:   HBG729392
- OMA:   EIMADAR
- BioCyc:   NSP35761:NOCA_2511-MONOMER
- HAMAP:   MF_00719
- InterPro:   IPR003805

Pfam domain/function: PF02654 CobS

EC number: 2.7.8.26

Molecular weight: Translated: 23053; Mature: 23053

Theoretical pI: Translated: 11.25; Mature: 11.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17746918)-; HASH(0x19051a08)-; HASH(0x18a9fc70)-; HASH(0x19314fc0)-; HASH(0x1871cf8c)-; HASH(0x19119c64)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAWRFAVGTLTALPVRPPTRVDRDTARRAMLLAPLAALPLGLLVAAVLAAGRAVELPP
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
LAVGLLAVGALAASSRALHWDGLSDTVDGLAASYDPARSLAVMRSGTSGPAGVLATVVVA
HHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHH
GVQAAALATLLDQPLLAGALVCLSRCALWIVCCTRVPAARADGLGADVARTVPLPVAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHCCHHHHHHH
GLLLSAVGGLVVLVLVRRTVRRFGGVTGDVMGAAVELALAATLLAWAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MRDAWRFAVGTLTALPVRPPTRVDRDTARRAMLLAPLAALPLGLLVAAVLAAGRAVELPP
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
LAVGLLAVGALAASSRALHWDGLSDTVDGLAASYDPARSLAVMRSGTSGPAGVLATVVVA
HHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHH
GVQAAALATLLDQPLLAGALVCLSRCALWIVCCTRVPAARADGLGADVARTVPLPVAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHCCHHHHHHH
GLLLSAVGGLVVLVLVRRTVRRFGGVTGDVMGAAVELALAATLLAWAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA