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The map label for this gene is nei [C]

Identifier: 119716555

GI number: 119716555

Start: 2482043

End: 2482849

Strand: Reverse

Name: nei [C]

Synonym: Noca_2328

Alternate gene names: 119716555

Gene position: 2482849-2482043 (Counterclockwise)

Preceding gene: 119716556

Following gene: 119716550

Centisome position: 49.8

GC content: 74.47

Gene sequence:

>807_bases
GTGCCTGAGGGCGACGCCGTGTGGCGCACCGCCGAGCGCCTGCGCCGGGCGCTCGACGGGCAGCGGCTGGTGCGCACCGA
CCTCCGCGTCCCGCAGCACGCCACCACCGACCTCTCGGGCGGCACGGTCCTCGAGACCGTCTCCCGCGGCAAGCACCTGC
TCACCCGGATCAACACCCACTCCGACCACGGGGCCGAGGACTGGACGCTGCACACCCACCTGAAGATGGAGGGTTCGTGG
CGCGTCTACCGCGCCGGCGAGCGCTGGACCAAGCCCGCCCACCTGGCCCGGGTGGTGCTCGACGTCGGCGGCCGCAGCGC
CGTCGGCTTCCAGCTCGGCGTGGTGGACCTGCTGCCCCGCGAGCGTGAGGACGAGGTCGTCGGGCACCTGGGTCCGGACC
TGCTCGGCCCGGACTGGGACGCCGAGGAGGCGGTCCGCCGGCTCACCGCCGACCCGACCCGACCGCTCGGCGAGGCCCTG
CTGGACCAGCGCAACCTCGCCGGGATCGGGACGATCTACCGCAGCGAGCTGTGCTTCCTCACCGGCTACGACCCGCGCGA
CCCGCTCGCCGTGGTCGCCGACCCGCTCCGGATGGTCCGGCTGGCGCGCTCGATGCTCGACCAGAACCGCCACCAGGCCC
AGATCTGCACCACCGGCGACAAGCGCCGGGGCCGCAGCCTCTGGGTCTACGGGCGCTCCGGCGAGCGCTGCCTGCGGTGC
GGCACGACGATCGTGCACGACCAGCTCGGTCAGCCGGGGCGCGAGCGAATCGCCTACTGGTGCCCGTCCTGCCAGCCACG
CCGCTAG

Upstream 100 bases:

>100_bases
GAGCAGCTGCTCGGCTCCGGTTCGACACCGCTGCGCGCGGCGCTCCAGGCCGCCGGGTTCGTCGCGACCCCGAAGGGGCT
GCGGCTGCGGGCGGCCGCCG

Downstream 100 bases:

>100_bases
CGACTACCGCAGGCCCAGCCCCTCGATCCGGACCGGCTTGCCGCTCAGCGTCCGGATCGTCAGCCGGCCGCTGGTCGGGT
GCGACAGGGTCGCCACGGGG

Product: formamidopyrimidine-DNA glycolase

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase SCO5760; Putative AP lyase SCO5760 [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPEGDAVWRTAERLRRALDGQRLVRTDLRVPQHATTDLSGGTVLETVSRGKHLLTRINTHSDHGAEDWTLHTHLKMEGSW
RVYRAGERWTKPAHLARVVLDVGGRSAVGFQLGVVDLLPREREDEVVGHLGPDLLGPDWDAEEAVRRLTADPTRPLGEAL
LDQRNLAGIGTIYRSELCFLTGYDPRDPLAVVADPLRMVRLARSMLDQNRHQAQICTTGDKRRGRSLWVYGRSGERCLRC
GTTIVHDQLGQPGRERIAYWCPSCQPRR

Sequences:

>Translated_268_residues
MPEGDAVWRTAERLRRALDGQRLVRTDLRVPQHATTDLSGGTVLETVSRGKHLLTRINTHSDHGAEDWTLHTHLKMEGSW
RVYRAGERWTKPAHLARVVLDVGGRSAVGFQLGVVDLLPREREDEVVGHLGPDLLGPDWDAEEAVRRLTADPTRPLGEAL
LDQRNLAGIGTIYRSELCFLTGYDPRDPLAVVADPLRMVRLARSMLDQNRHQAQICTTGDKRRGRSLWVYGRSGERCLRC
GTTIVHDQLGQPGRERIAYWCPSCQPRR
>Mature_267_residues
PEGDAVWRTAERLRRALDGQRLVRTDLRVPQHATTDLSGGTVLETVSRGKHLLTRINTHSDHGAEDWTLHTHLKMEGSWR
VYRAGERWTKPAHLARVVLDVGGRSAVGFQLGVVDLLPREREDEVVGHLGPDLLGPDWDAEEAVRRLTADPTRPLGEALL
DQRNLAGIGTIYRSELCFLTGYDPRDPLAVVADPLRMVRLARSMLDQNRHQAQICTTGDKRRGRSLWVYGRSGERCLRCG
TTIVHDQLGQPGRERIAYWCPSCQPRR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1786932, Length=283, Percent_Identity=29.3286219081272, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 30213; Mature: 30082

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGDAVWRTAERLRRALDGQRLVRTDLRVPQHATTDLSGGTVLETVSRGKHLLTRINTH
CCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
SDHGAEDWTLHTHLKMEGSWRVYRAGERWTKPAHLARVVLDVGGRSAVGFQLGVVDLLPR
CCCCCCCEEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEECHHHHCCC
EREDEVVGHLGPDLLGPDWDAEEAVRRLTADPTRPLGEALLDQRNLAGIGTIYRSELCFL
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCEEEE
TGYDPRDPLAVVADPLRMVRLARSMLDQNRHQAQICTTGDKRRGRSLWVYGRSGERCLRC
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHH
GTTIVHDQLGQPGRERIAYWCPSCQPRR
CCHHHHHHCCCCHHHHHEEECCCCCCCC
>Mature Secondary Structure 
PEGDAVWRTAERLRRALDGQRLVRTDLRVPQHATTDLSGGTVLETVSRGKHLLTRINTH
CCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
SDHGAEDWTLHTHLKMEGSWRVYRAGERWTKPAHLARVVLDVGGRSAVGFQLGVVDLLPR
CCCCCCCEEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEECHHHHCCC
EREDEVVGHLGPDLLGPDWDAEEAVRRLTADPTRPLGEALLDQRNLAGIGTIYRSELCFL
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCEEEE
TGYDPRDPLAVVADPLRMVRLARSMLDQNRHQAQICTTGDKRRGRSLWVYGRSGERCLRC
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHH
GTTIVHDQLGQPGRERIAYWCPSCQPRR
CCHHHHHHCCCCHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]