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The map label for this gene is pepA [H]

Identifier: 119716533

GI number: 119716533

Start: 2455931

End: 2457424

Strand: Reverse

Name: pepA [H]

Synonym: Noca_2306

Alternate gene names: 119716533

Gene position: 2457424-2455931 (Counterclockwise)

Preceding gene: 119716541

Following gene: 119716531

Centisome position: 49.29

GC content: 74.03

Gene sequence:

>1494_bases
ATGCGCAGCGCCAGCCCCGCCAAGACCCGCAGCGACGCCGTCGTGGTGGGGGTCGTCCAAGGCGCCAAGGGGCCGACCCT
CGCCGACGGCGGCGAGGACGTCGCCTCCGCCTACGGCCGCAAGCTGCGCCCCCTGCTCGCCACGCTCGGGGTGACCGGCA
AGGCGGGCGAGGTCGCCAAGGTCCCGACCAGCGGCGCGATCACCTCCCCGCTGCTGGTGCTGGTCGGGCTCGGCGCGACC
CCCGACACCGAGGCGGTACGCCGGGGCGCGGGCGTCGCGGCTCGCGCGGTCACCAACGCCGCCTCGGTCGCGATCGCACT
GCCCGCCGGGACGCCCGAGCTGGTCCGCGCCGTGACCGAGGGCTACGAGCTCGGGGGCTACACGTTCACGACGTACAAGA
AGCCGGCCGCGGAGGCGAAGGGCGCACCGGCCGACGTGGTCCTGCTCAGCGGCGCCGCGCGCAAGAAGGACGTGGTAGCC
GCGTTCGAGCAGGCGCGGATCGTCTCCGCCGCCGTCGCGGCGACCCGGGACTGGGTCAACACGCCGCCCGGCGACCTGAC
CCCGCCCGCCTTCGCCGACACCGTCGCCGAGGCGACCAAGGCACTCACCAAGGGGCGCGGCGCCCCGAAGGTGTCCATCC
GGGTCCTCGACGAGAAGGAGCTCGCCGAGCTCGGCTGCGGCGGCATCCTCGGCGTCGGTGCCGGCTCGTCGGCGCCGCCG
CGGCTGGTCGAGCTGAGCTATGCGCCGAAGGGCGCCAAGCACCACCTTGCGCTCGTCGGCAAGGGCATCACCTTCGACTC
CGGCGGGCTGACCATCAAGCCGGCGCAGAGCATGAGCGAGATGAAGTCGGACATGGCCGGCGCCGCTGCGGTCGTCCAGG
CGACGTTCGCGATCGCCCGGCTGGGCCTGCCCGTGCAGGTGTCGACGTACGCGCCGATGGCGGAGAACATGCTGTCGGGC
TCGGCGACCCGGCCCGGCGACGTCTTGTCGATGTACGGCGGCACCACGGTCGAGGTGCTCAACACCGACGCCGAGGGCCG
CCTGGTGCTCGCCGACGCCCTGGTCCGCGCGACCGAGGTGAAGCCGGACGTGATCATCGACGTCGCCACCCTGACCGGCC
ACATGGTCGTCGCCTTGGGCGACCGGGTCAGCGGCGTGCTCGGGTCGACCGACGTCGTCGACGACGTGCTCGCGGCCGCC
GGCACGGCCGGCGAGGCGATGTGGCCGATGCCGATCCCGGAGTCGATGCGCGAGCGGATCACCTCCAGCAAGATCGCCGA
CCTCGCCCAGCACGACTGGACCCGGTGGGGCGGCGGGCTGTTCGCCGCGGCGTTCCTGCGCGAGTTCACCGGGGGCCTGC
CCTGGGCGCACCTCGACATCGCCGGGCCGTCGTTCAACTCCGGCGGCGCCTGGGGGCACGTCACCGCCGGCGGCACCGGT
GTCGCCGTCGCCACCCTGGTCGACTACGCCCGGGCACTGTCCGAGCAGAAGTAG

Upstream 100 bases:

>100_bases
GCGTGGAGCGGGGAGCGCAGCTCCTGTTCGTGGAGGTCCACCATGGCCGCGAACCTACCGCAGCACCCCGGACTATCCTG
CCCCGGTGACGTCGTACACC

Downstream 100 bases:

>100_bases
GCGGGCGGGTTCAGAGCCCGCCCTCGAGCTTCTTGCGCCGGTTGTAGTCCCGCATCCGCTGCGGGATGCCGACGACCGCG
GCGTCGTAGGAGGGGATCTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MRSASPAKTRSDAVVVGVVQGAKGPTLADGGEDVASAYGRKLRPLLATLGVTGKAGEVAKVPTSGAITSPLLVLVGLGAT
PDTEAVRRGAGVAARAVTNAASVAIALPAGTPELVRAVTEGYELGGYTFTTYKKPAAEAKGAPADVVLLSGAARKKDVVA
AFEQARIVSAAVAATRDWVNTPPGDLTPPAFADTVAEATKALTKGRGAPKVSIRVLDEKELAELGCGGILGVGAGSSAPP
RLVELSYAPKGAKHHLALVGKGITFDSGGLTIKPAQSMSEMKSDMAGAAAVVQATFAIARLGLPVQVSTYAPMAENMLSG
SATRPGDVLSMYGGTTVEVLNTDAEGRLVLADALVRATEVKPDVIIDVATLTGHMVVALGDRVSGVLGSTDVVDDVLAAA
GTAGEAMWPMPIPESMRERITSSKIADLAQHDWTRWGGGLFAAAFLREFTGGLPWAHLDIAGPSFNSGGAWGHVTAGGTG
VAVATLVDYARALSEQK

Sequences:

>Translated_497_residues
MRSASPAKTRSDAVVVGVVQGAKGPTLADGGEDVASAYGRKLRPLLATLGVTGKAGEVAKVPTSGAITSPLLVLVGLGAT
PDTEAVRRGAGVAARAVTNAASVAIALPAGTPELVRAVTEGYELGGYTFTTYKKPAAEAKGAPADVVLLSGAARKKDVVA
AFEQARIVSAAVAATRDWVNTPPGDLTPPAFADTVAEATKALTKGRGAPKVSIRVLDEKELAELGCGGILGVGAGSSAPP
RLVELSYAPKGAKHHLALVGKGITFDSGGLTIKPAQSMSEMKSDMAGAAAVVQATFAIARLGLPVQVSTYAPMAENMLSG
SATRPGDVLSMYGGTTVEVLNTDAEGRLVLADALVRATEVKPDVIIDVATLTGHMVVALGDRVSGVLGSTDVVDDVLAAA
GTAGEAMWPMPIPESMRERITSSKIADLAQHDWTRWGGGLFAAAFLREFTGGLPWAHLDIAGPSFNSGGAWGHVTAGGTG
VAVATLVDYARALSEQK
>Mature_497_residues
MRSASPAKTRSDAVVVGVVQGAKGPTLADGGEDVASAYGRKLRPLLATLGVTGKAGEVAKVPTSGAITSPLLVLVGLGAT
PDTEAVRRGAGVAARAVTNAASVAIALPAGTPELVRAVTEGYELGGYTFTTYKKPAAEAKGAPADVVLLSGAARKKDVVA
AFEQARIVSAAVAATRDWVNTPPGDLTPPAFADTVAEATKALTKGRGAPKVSIRVLDEKELAELGCGGILGVGAGSSAPP
RLVELSYAPKGAKHHLALVGKGITFDSGGLTIKPAQSMSEMKSDMAGAAAVVQATFAIARLGLPVQVSTYAPMAENMLSG
SATRPGDVLSMYGGTTVEVLNTDAEGRLVLADALVRATEVKPDVIIDVATLTGHMVVALGDRVSGVLGSTDVVDDVLAAA
GTAGEAMWPMPIPESMRERITSSKIADLAQHDWTRWGGGLFAAAFLREFTGGLPWAHLDIAGPSFNSGGAWGHVTAGGTG
VAVATLVDYARALSEQK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=516, Percent_Identity=31.9767441860465, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=36.3924050632911, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1790710, Length=504, Percent_Identity=32.3412698412698, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082123, Length=322, Percent_Identity=38.1987577639752, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=306, Percent_Identity=36.6013071895425, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=345, Percent_Identity=27.536231884058, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24661038, Length=480, Percent_Identity=30, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21355725, Length=412, Percent_Identity=31.0679611650485, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221379063, Length=300, Percent_Identity=36.6666666666667, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221379062, Length=300, Percent_Identity=36.6666666666667, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21357381, Length=300, Percent_Identity=36.6666666666667, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129969, Length=486, Percent_Identity=28.6008230452675, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662227, Length=479, Percent_Identity=26.7223382045929, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922386, Length=473, Percent_Identity=28.5412262156448, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21355645, Length=510, Percent_Identity=25.4901960784314, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24662223, Length=510, Percent_Identity=25.4901960784314, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129963, Length=474, Percent_Identity=27.4261603375527, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077148, Length=294, Percent_Identity=31.2925170068027, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20130057, Length=294, Percent_Identity=31.2925170068027, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646701, Length=235, Percent_Identity=30.6382978723404, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646703, Length=235, Percent_Identity=30.6382978723404, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358201, Length=235, Percent_Identity=30.6382978723404, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50359; Mature: 50359

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSASPAKTRSDAVVVGVVQGAKGPTLADGGEDVASAYGRKLRPLLATLGVTGKAGEVAK
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VPTSGAITSPLLVLVGLGATPDTEAVRRGAGVAARAVTNAASVAIALPAGTPELVRAVTE
CCCCCCHHHHHHHEEECCCCCCHHHHHHCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHC
GYELGGYTFTTYKKPAAEAKGAPADVVLLSGAARKKDVVAAFEQARIVSAAVAATRDWVN
CCCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPGDLTPPAFADTVAEATKALTKGRGAPKVSIRVLDEKELAELGCGGILGVGAGSSAPP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHCCCCEEEECCCCCCCC
RLVELSYAPKGAKHHLALVGKGITFDSGGLTIKPAQSMSEMKSDMAGAAAVVQATFAIAR
CEEEEECCCCCCCCEEEEEECCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPVQVSTYAPMAENMLSGSATRPGDVLSMYGGTTVEVLNTDAEGRLVLADALVRATEV
CCCCEEECCCCHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCEEHHHHHHHHHCC
KPDVIIDVATLTGHMVVALGDRVSGVLGSTDVVDDVLAAAGTAGEAMWPMPIPESMRERI
CCCEEEEEEHHCCCEEEEECCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
TSSKIADLAQHDWTRWGGGLFAAAFLREFTGGLPWAHLDIAGPSFNSGGAWGHVTAGGTG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCH
VAVATLVDYARALSEQK
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSASPAKTRSDAVVVGVVQGAKGPTLADGGEDVASAYGRKLRPLLATLGVTGKAGEVAK
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VPTSGAITSPLLVLVGLGATPDTEAVRRGAGVAARAVTNAASVAIALPAGTPELVRAVTE
CCCCCCHHHHHHHEEECCCCCCHHHHHHCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHC
GYELGGYTFTTYKKPAAEAKGAPADVVLLSGAARKKDVVAAFEQARIVSAAVAATRDWVN
CCCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPGDLTPPAFADTVAEATKALTKGRGAPKVSIRVLDEKELAELGCGGILGVGAGSSAPP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHCCCCEEEECCCCCCCC
RLVELSYAPKGAKHHLALVGKGITFDSGGLTIKPAQSMSEMKSDMAGAAAVVQATFAIAR
CEEEEECCCCCCCCEEEEEECCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPVQVSTYAPMAENMLSGSATRPGDVLSMYGGTTVEVLNTDAEGRLVLADALVRATEV
CCCCEEECCCCHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCEEHHHHHHHHHCC
KPDVIIDVATLTGHMVVALGDRVSGVLGSTDVVDDVLAAAGTAGEAMWPMPIPESMRERI
CCCEEEEEEHHCCCEEEEECCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
TSSKIADLAQHDWTRWGGGLFAAAFLREFTGGLPWAHLDIAGPSFNSGGAWGHVTAGGTG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCH
VAVATLVDYARALSEQK
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA