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The map label for this gene is pyrB [H]

Identifier: 119715274

GI number: 119715274

Start: 1087473

End: 1088348

Strand: Reverse

Name: pyrB [H]

Synonym: Noca_1033

Alternate gene names: 119715274

Gene position: 1088348-1087473 (Counterclockwise)

Preceding gene: 119715275

Following gene: 119715273

Centisome position: 21.83

GC content: 63.93

Gene sequence:

>876_bases
GTGAAGCAGCACCTGCTCTCGATCGACGACCTCGCGATCGACGCCGTGGACGCTCTGTTCGTCCGCGCGCAGGAGCTCTC
TGGAGGGCCGGGCTTTCGAGCGCCCGTTCGCCACGCGGCATTGTTGTTCTTCGAGACGTCCTTGCGGACTCGGACCGGCT
TTGTCTCCGCGGCGCACCGACTCGGGTGGCCGACGCCGATCGAGGTTCTTGAGCGGCGGGCAAGTGCATCCTCCATGCCC
GAGAGCTTGCGCGACACTGTTGGAGTCGTGTCGGCGTACTTCGACACTCTCATCGTTCGGCACGATGGCGCCATTGCTGA
TGTCGTGCCGCTGGTTCGCCAGGGAACGGTCGTCATCAACGCAGGCGATCGTGGGCCGAGCTCTGAGCACCCCACCCAAG
CTCTCATCGACGTCTTCGCGATGAGCCAACTCGTCGGTGAGATTCAGGACCTCAGCATCGTTGTCGCTGGCGATCTCCGA
ATGCGTGCGGCACGCAGTCTGCTGAATCTGCTGGCTCGCAGACCGCCAAGGGGCCTCGTGCTGGTCACAGATCCGGCGCT
CACTGAGGGTCTCGAGCTCCCTGTCGCGCTCCGAGAGGCCCCAATGGTTGACAGCTACGACGATCTCGAGCGCATTGACG
CGCTCCATGCCATCGGGATCCCAAACGGCAGCGTCGAGGAGAACGTGCGCAGTAGGCTGCGCGTCGATGCACGAGTACTC
GCCCGCCTGAGCGCTCGAGGCAAGGTGTTCTCGCCCATGCCGGTCATCGACGAAGTCGATCGCGACATTCGGGGCGACCC
GCGCCTTGCTTTCCTGGAGCAAAGCGCCCTTGCGCTTCCGGTACGGATGGCCGTTCTGGAGTCATTCACCTTGTAG

Upstream 100 bases:

>100_bases
CATACCTCGGTCCAACCTGCGATCCCTGCACCCACAACACGCTTACGTTCGCACTAGGTGGCAAGCACGCTCACACGCCG
AATCTGCTGACGGGAGCGGC

Downstream 100 bases:

>100_bases
GCCCGGCTCTGGGAACAGTTACTCTTTTGTGCCGATCAACATTTTCGACGACCAGTCCGGGAGCGGCAATCCTCCGCAGC
TCTCCCCTGCTGCCACGACG

Product: aspartate carbamoyltransferase

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKQHLLSIDDLAIDAVDALFVRAQELSGGPGFRAPVRHAALLFFETSLRTRTGFVSAAHRLGWPTPIEVLERRASASSMP
ESLRDTVGVVSAYFDTLIVRHDGAIADVVPLVRQGTVVINAGDRGPSSEHPTQALIDVFAMSQLVGEIQDLSIVVAGDLR
MRAARSLLNLLARRPPRGLVLVTDPALTEGLELPVALREAPMVDSYDDLERIDALHAIGIPNGSVEENVRSRLRVDARVL
ARLSARGKVFSPMPVIDEVDRDIRGDPRLAFLEQSALALPVRMAVLESFTL

Sequences:

>Translated_291_residues
MKQHLLSIDDLAIDAVDALFVRAQELSGGPGFRAPVRHAALLFFETSLRTRTGFVSAAHRLGWPTPIEVLERRASASSMP
ESLRDTVGVVSAYFDTLIVRHDGAIADVVPLVRQGTVVINAGDRGPSSEHPTQALIDVFAMSQLVGEIQDLSIVVAGDLR
MRAARSLLNLLARRPPRGLVLVTDPALTEGLELPVALREAPMVDSYDDLERIDALHAIGIPNGSVEENVRSRLRVDARVL
ARLSARGKVFSPMPVIDEVDRDIRGDPRLAFLEQSALALPVRMAVLESFTL
>Mature_291_residues
MKQHLLSIDDLAIDAVDALFVRAQELSGGPGFRAPVRHAALLFFETSLRTRTGFVSAAHRLGWPTPIEVLERRASASSMP
ESLRDTVGVVSAYFDTLIVRHDGAIADVVPLVRQGTVVINAGDRGPSSEHPTQALIDVFAMSQLVGEIQDLSIVVAGDLR
MRAARSLLNLLARRPPRGLVLVTDPALTEGLELPVALREAPMVDSYDDLERIDALHAIGIPNGSVEENVRSRLRVDARVL
ARLSARGKVFSPMPVIDEVDRDIRGDPRLAFLEQSALALPVRMAVLESFTL

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=314, Percent_Identity=28.343949044586, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI2367364, Length=300, Percent_Identity=28.3333333333333, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=277, Percent_Identity=29.2418772563177, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322331, Length=307, Percent_Identity=29.3159609120521, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642586, Length=305, Percent_Identity=30.4918032786885, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 31656; Mature: 31656

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHLLSIDDLAIDAVDALFVRAQELSGGPGFRAPVRHAALLFFETSLRTRTGFVSAAHR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGWPTPIEVLERRASASSMPESLRDTVGVVSAYFDTLIVRHDGAIADVVPLVRQGTVVIN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEE
AGDRGPSSEHPTQALIDVFAMSQLVGEIQDLSIVVAGDLRMRAARSLLNLLARRPPRGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCEE
LVTDPALTEGLELPVALREAPMVDSYDDLERIDALHAIGIPNGSVEENVRSRLRVDARVL
EEECCHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ARLSARGKVFSPMPVIDEVDRDIRGDPRLAFLEQSALALPVRMAVLESFTL
HHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQHLLSIDDLAIDAVDALFVRAQELSGGPGFRAPVRHAALLFFETSLRTRTGFVSAAHR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGWPTPIEVLERRASASSMPESLRDTVGVVSAYFDTLIVRHDGAIADVVPLVRQGTVVIN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEE
AGDRGPSSEHPTQALIDVFAMSQLVGEIQDLSIVVAGDLRMRAARSLLNLLARRPPRGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCEE
LVTDPALTEGLELPVALREAPMVDSYDDLERIDALHAIGIPNGSVEENVRSRLRVDARVL
EEECCHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ARLSARGKVFSPMPVIDEVDRDIRGDPRLAFLEQSALALPVRMAVLESFTL
HHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]