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The map label for this gene is alsR [H]

Identifier: 119715253

GI number: 119715253

Start: 1064286

End: 1065203

Strand: Reverse

Name: alsR [H]

Synonym: Noca_1012

Alternate gene names: 119715253

Gene position: 1065203-1064286 (Counterclockwise)

Preceding gene: 119715259

Following gene: 119715251

Centisome position: 21.36

GC content: 76.03

Gene sequence:

>918_bases
ATGGAGCTGCGGCACGTGCGCTACGCCCTCGCGCTGGCCGAGGAGCGACACTTCGGCCGGGCGGCCGCGCGGGTGCACGT
CGCCCAGCCGGCGCTCTCCCAGCAGGTCAAGCAGCTCGAGCGCGAGCTCGGCGTCGAGCTGTTCCGCCGCACCACGCGGC
GCGTCGAGCTCACCGAGGCCGGCCGCCGGTTCGCCGAGCATGCCCGCGGGATCCTGGCCGGAGTCGACCGGGCCCGCGAG
GACCTCGCGCTGCTCGCCTCGGGCCGGGCCGGGCGGGTCTCGGTCGGGTTCGTCGGCACCGCGACGTACGACGTGCTCCC
CCGGGTCGCCCACGAGGTGCACCGCGCGCTCCCCGACGTCGACCTGCAGCTGCGCGGCGAGTCGCTCAGCCCCCGGCTGC
TGGCCGGGCTCGCCGACCACACCTTCGACCTGGCCCTGCTGCGGCCCGATCCGCTCGGCGGCGACGGGCTGGTGGTCCGC
ACGCTGCGGGCCGAGCCGCTGGTGGCCGTCGTACCGACCGGCCACCCGCTCGCCGGACAGCGCCGCATCGACCTGGCCGA
GCTGGCCGGCGAGTCGTTCGTCGTGCACCCGTCGGCGCACCGGTCGTCCATCCACGAGCGGGTGCTCCAGGCCTGCGCCG
ACGCCGGGTTCGTGCCCACCTCGCTCCTGGAGGTGGCCGAGACCGCCACGATGGTGGTCTTCGTCGCGGCCGGCCTCGGC
GTCGCGCTGGTCCCTGAGCCGGTGCGCAGCCTCGGCCTCGAGGGGGTGTCGTACGTCGGGCTCACCGACCCGCCCACGAT
CGACCTGGCGCTGGCCGGGCGGCGGGACGAGTCCTCCCCGGCCGTGCGCAACGTCGCCGTGATCATCGAGCGGATCGTCA
CCGGGGCCGCTCAGCAGGGGGCGCGTGTCCACCTGTAA

Upstream 100 bases:

>100_bases
ACGCAGGCGTGCTCATGCTCCCGACGCTAGACCGGGTGATCTATCGGGTCCAATACTCATTGGTGCTCGATTCATCGCTA
CGGCCGATAGGATTGTGGCC

Downstream 100 bases:

>100_bases
CGCCCTGTTACCCCTTCCTCCCACCGTGCTGCAGCTGGGCCGGTGGGCAGGGTAACCGGGCGTTACAGCGAGCCGGCGCC
GTCCTCCCCCAGCACCTCCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELRHVRYALALAEERHFGRAAARVHVAQPALSQQVKQLERELGVELFRRTTRRVELTEAGRRFAEHARGILAGVDRARE
DLALLASGRAGRVSVGFVGTATYDVLPRVAHEVHRALPDVDLQLRGESLSPRLLAGLADHTFDLALLRPDPLGGDGLVVR
TLRAEPLVAVVPTGHPLAGQRRIDLAELAGESFVVHPSAHRSSIHERVLQACADAGFVPTSLLEVAETATMVVFVAAGLG
VALVPEPVRSLGLEGVSYVGLTDPPTIDLALAGRRDESSPAVRNVAVIIERIVTGAAQQGARVHL

Sequences:

>Translated_305_residues
MELRHVRYALALAEERHFGRAAARVHVAQPALSQQVKQLERELGVELFRRTTRRVELTEAGRRFAEHARGILAGVDRARE
DLALLASGRAGRVSVGFVGTATYDVLPRVAHEVHRALPDVDLQLRGESLSPRLLAGLADHTFDLALLRPDPLGGDGLVVR
TLRAEPLVAVVPTGHPLAGQRRIDLAELAGESFVVHPSAHRSSIHERVLQACADAGFVPTSLLEVAETATMVVFVAAGLG
VALVPEPVRSLGLEGVSYVGLTDPPTIDLALAGRRDESSPAVRNVAVIIERIVTGAAQQGARVHL
>Mature_305_residues
MELRHVRYALALAEERHFGRAAARVHVAQPALSQQVKQLERELGVELFRRTTRRVELTEAGRRFAEHARGILAGVDRARE
DLALLASGRAGRVSVGFVGTATYDVLPRVAHEVHRALPDVDLQLRGESLSPRLLAGLADHTFDLALLRPDPLGGDGLVVR
TLRAEPLVAVVPTGHPLAGQRRIDLAELAGESFVVHPSAHRSSIHERVLQACADAGFVPTSLLEVAETATMVVFVAAGLG
VALVPEPVRSLGLEGVSYVGLTDPPTIDLALAGRRDESSPAVRNVAVIIERIVTGAAQQGARVHL

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=36.2068965517241, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI2367136, Length=281, Percent_Identity=30.9608540925267, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=30.6666666666667, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790399, Length=271, Percent_Identity=31.3653136531365, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=27.6422764227642, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI157672245, Length=278, Percent_Identity=31.294964028777, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=31.4516129032258, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=244, Percent_Identity=27.0491803278689, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87081904, Length=229, Percent_Identity=31.0043668122271, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=29.7619047619048, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=250, Percent_Identity=27.2, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789204, Length=247, Percent_Identity=25.9109311740891, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=28.5140562248996, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787601, Length=264, Percent_Identity=26.5151515151515, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787589, Length=115, Percent_Identity=37.3913043478261, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=228, Percent_Identity=25.8771929824561, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=25.0996015936255, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32682; Mature: 32682

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHVRYALALAEERHFGRAAARVHVAQPALSQQVKQLERELGVELFRRTTRRVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
GRRFAEHARGILAGVDRAREDLALLASGRAGRVSVGFVGTATYDVLPRVAHEVHRALPDV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCC
DLQLRGESLSPRLLAGLADHTFDLALLRPDPLGGDGLVVRTLRAEPLVAVVPTGHPLAGQ
CEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
RRIDLAELAGESFVVHPSAHRSSIHERVLQACADAGFVPTSLLEVAETATMVVFVAAGLG
CCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
VALVPEPVRSLGLEGVSYVGLTDPPTIDLALAGRRDESSPAVRNVAVIIERIVTGAAQQG
EEECCHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
ARVHL
CEECC
>Mature Secondary Structure
MELRHVRYALALAEERHFGRAAARVHVAQPALSQQVKQLERELGVELFRRTTRRVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
GRRFAEHARGILAGVDRAREDLALLASGRAGRVSVGFVGTATYDVLPRVAHEVHRALPDV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCC
DLQLRGESLSPRLLAGLADHTFDLALLRPDPLGGDGLVVRTLRAEPLVAVVPTGHPLAGQ
CEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
RRIDLAELAGESFVVHPSAHRSSIHERVLQACADAGFVPTSLLEVAETATMVVFVAAGLG
CCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
VALVPEPVRSLGLEGVSYVGLTDPPTIDLALAGRRDESSPAVRNVAVIIERIVTGAAQQG
EEECCHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
ARVHL
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]