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The map label for this gene is tdcB [H]

Identifier: 119715223

GI number: 119715223

Start: 1028088

End: 1029302

Strand: Direct

Name: tdcB [H]

Synonym: Noca_0979

Alternate gene names: 119715223

Gene position: 1028088-1029302 (Clockwise)

Preceding gene: 119715222

Following gene: 119715225

Centisome position: 20.62

GC content: 74.16

Gene sequence:

>1215_bases
ATGACTGAGGTCCCGACGGTCGGGCTGGCCGACATCGAGGAGGCCCGCCGGGTCCTGGCCGGCGTCGCGATCCAGACCCC
GATGGAGGAGTCCCGCTGGCTCTCGGCGATCGCCGGCGGGCCGGTGTGGCTCAAGTGCGAGAACCTCCAGCGCACCGGGT
CCTTCAAGCCCCGCGGCGCCTACGTGCGCATCTCCCGGCTCACCCCCGAGGAGCGGGCCCGCGGGGTCGTGGCGGCCTCG
GCGGGCAACCACGCGCAGGGCGTGGCGCTGGCCGCGCAGCTGCTCGGCATCAAGGCCACCGTCTTCATGCCCGAGGGGGC
GCCGATCCCCAAGGAGAAGGCGACCCGCGGGTACGGCGCGGAGGTGCTCTTCCACGGCCGGTACCTCGAGGACGCGCTGG
CCGAGGCGACCGTGTTCGCCGAGCGCACCGGCGCGGTGCTGATCCACCCCTTCGACCACGCCGACGTCGTCGCCGGCCAG
GGCACGGCCGGCCTCGAGATCCTCGAGCAGGCGCCCGACCTGCAGACGGTGCTGGTCCCCACCGGCGGTGGTGGGCTGCT
GGCGGGGGTCGCGATCGCGGTGAAGGCGCGGCGCCCCGACGTCCGGGTGATCGGGGTGCAGGCGGCCGGCGCCGCGGCGT
ACCCCGGCTCGCTCGCCGAGGGGCACCCCGTCGCCCTGACCTCGATGAAGACGATGGCCGACGGCATCGCCGTGGGCCTC
CCGGGGCAGGTCACCTTCGCGGCGGTGCGCGACCACGTCGACGAGATCGTCACGGTCTCCGAGAACTCGCTGTCCCGCTC
GGTGCTGGCCGTGCTGGAGCGCGCGAAGATGCTGGTCGAGCCCGCCGGAGCGGCCGCGGTCGCCGCCGTGCTGGACCGGC
CGGACATCTTCGCGACCCCCGCGGTGGTCGTGCTCTCGGGCGGCAACATCGACCCCCTGCTGCTCGGCAAGGTGATCCGG
CACGGCATGGCGGCCGCCGGCCGCTACCTGAACCTACGGGTCTGCATCCCCGACCTGCCGGGCGGGCTCGCGCAGCTGCT
CACCGACATCTCCGCGGTCGGAGCGAACGTGCTCGAGGTCGCGCACGAGCGGATCTCACCCACGCTGAACCTCGACGAGG
TCGAGGTGCACGTCCAGCTCGAGACCCGCGGGGAGCCGCACACCGCGCAGGTGCTGGCGCGCCTGCGCGAGCGCGGCTAC
CGCGTGTACGAGTAG

Upstream 100 bases:

>100_bases
GTCAGCACCGACATCGGGGAGGACGACCCGGTCGAGGAGCTCGAGGAGGACTACGAGGAGATGGGCGCGTCCGCGGACGT
CCCGGAGGAGGACGGGCGTG

Downstream 100 bases:

>100_bases
CCGAGGTCGCTCACCCCTCGTAGGGGACGGCGTCGACGATGACGACCTGGAGCTCCTTGCCGTTGGGCGCGAGGTAGCTG
ACGGTGTCGCCCTTCGCCTT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTEVPTVGLADIEEARRVLAGVAIQTPMEESRWLSAIAGGPVWLKCENLQRTGSFKPRGAYVRISRLTPEERARGVVAAS
AGNHAQGVALAAQLLGIKATVFMPEGAPIPKEKATRGYGAEVLFHGRYLEDALAEATVFAERTGAVLIHPFDHADVVAGQ
GTAGLEILEQAPDLQTVLVPTGGGGLLAGVAIAVKARRPDVRVIGVQAAGAAAYPGSLAEGHPVALTSMKTMADGIAVGL
PGQVTFAAVRDHVDEIVTVSENSLSRSVLAVLERAKMLVEPAGAAAVAAVLDRPDIFATPAVVVLSGGNIDPLLLGKVIR
HGMAAAGRYLNLRVCIPDLPGGLAQLLTDISAVGANVLEVAHERISPTLNLDEVEVHVQLETRGEPHTAQVLARLRERGY
RVYE

Sequences:

>Translated_404_residues
MTEVPTVGLADIEEARRVLAGVAIQTPMEESRWLSAIAGGPVWLKCENLQRTGSFKPRGAYVRISRLTPEERARGVVAAS
AGNHAQGVALAAQLLGIKATVFMPEGAPIPKEKATRGYGAEVLFHGRYLEDALAEATVFAERTGAVLIHPFDHADVVAGQ
GTAGLEILEQAPDLQTVLVPTGGGGLLAGVAIAVKARRPDVRVIGVQAAGAAAYPGSLAEGHPVALTSMKTMADGIAVGL
PGQVTFAAVRDHVDEIVTVSENSLSRSVLAVLERAKMLVEPAGAAAVAAVLDRPDIFATPAVVVLSGGNIDPLLLGKVIR
HGMAAAGRYLNLRVCIPDLPGGLAQLLTDISAVGANVLEVAHERISPTLNLDEVEVHVQLETRGEPHTAQVLARLRERGY
RVYE
>Mature_403_residues
TEVPTVGLADIEEARRVLAGVAIQTPMEESRWLSAIAGGPVWLKCENLQRTGSFKPRGAYVRISRLTPEERARGVVAASA
GNHAQGVALAAQLLGIKATVFMPEGAPIPKEKATRGYGAEVLFHGRYLEDALAEATVFAERTGAVLIHPFDHADVVAGQG
TAGLEILEQAPDLQTVLVPTGGGGLLAGVAIAVKARRPDVRVIGVQAAGAAAYPGSLAEGHPVALTSMKTMADGIAVGLP
GQVTFAAVRDHVDEIVTVSENSLSRSVLAVLERAKMLVEPAGAAAVAAVLDRPDIFATPAVVVLSGGNIDPLLLGKVIRH
GMAAAGRYLNLRVCIPDLPGGLAQLLTDISAVGANVLEVAHERISPTLNLDEVEVHVQLETRGEPHTAQVLARLRERGYR
VYE

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=37.5796178343949, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI19923959, Length=304, Percent_Identity=31.5789473684211, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33469958, Length=276, Percent_Identity=28.6231884057971, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=45.9546925566343, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=36.0526315789474, Blast_Score=188, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=38.3631713554987, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17537387, Length=391, Percent_Identity=37.8516624040921, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17508781, Length=275, Percent_Identity=31.6363636363636, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322631, Length=309, Percent_Identity=40.7766990291262, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=341, Percent_Identity=36.950146627566, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=26.2068965517241, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355833, Length=395, Percent_Identity=36.4556962025316, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24645328, Length=304, Percent_Identity=35.8552631578947, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42277; Mature: 42146

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVPTVGLADIEEARRVLAGVAIQTPMEESRWLSAIAGGPVWLKCENLQRTGSFKPRGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
YVRISRLTPEERARGVVAASAGNHAQGVALAAQLLGIKATVFMPEGAPIPKEKATRGYGA
EEEEEECCHHHHHCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHCCCCCCC
EVLFHGRYLEDALAEATVFAERTGAVLIHPFDHADVVAGQGTAGLEILEQAPDLQTVLVP
EEEEECCHHHHHHHHHHHHEECCCEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEEE
TGGGGLLAGVAIAVKARRPDVRVIGVQAAGAAAYPGSLAEGHPVALTSMKTMADGIAVGL
CCCCHHHHHEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCEEECC
PGQVTFAAVRDHVDEIVTVSENSLSRSVLAVLERAKMLVEPAGAAAVAAVLDRPDIFATP
CCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECC
AVVVLSGGNIDPLLLGKVIRHGMAAAGRYLNLRVCIPDLPGGLAQLLTDISAVGANVLEV
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AHERISPTLNLDEVEVHVQLETRGEPHTAQVLARLRERGYRVYE
HHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEVPTVGLADIEEARRVLAGVAIQTPMEESRWLSAIAGGPVWLKCENLQRTGSFKPRGA
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
YVRISRLTPEERARGVVAASAGNHAQGVALAAQLLGIKATVFMPEGAPIPKEKATRGYGA
EEEEEECCHHHHHCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHCCCCCCC
EVLFHGRYLEDALAEATVFAERTGAVLIHPFDHADVVAGQGTAGLEILEQAPDLQTVLVP
EEEEECCHHHHHHHHHHHHEECCCEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEEE
TGGGGLLAGVAIAVKARRPDVRVIGVQAAGAAAYPGSLAEGHPVALTSMKTMADGIAVGL
CCCCHHHHHEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCEEECC
PGQVTFAAVRDHVDEIVTVSENSLSRSVLAVLERAKMLVEPAGAAAVAAVLDRPDIFATP
CCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECC
AVVVLSGGNIDPLLLGKVIRHGMAAAGRYLNLRVCIPDLPGGLAQLLTDISAVGANVLEV
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AHERISPTLNLDEVEVHVQLETRGEPHTAQVLARLRERGYRVYE
HHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA