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The map label for this gene is msrA [H]

Identifier: 119715219

GI number: 119715219

Start: 1022550

End: 1023194

Strand: Reverse

Name: msrA [H]

Synonym: Noca_0974

Alternate gene names: 119715219

Gene position: 1023194-1022550 (Counterclockwise)

Preceding gene: 119715224

Following gene: 119715217

Centisome position: 20.52

GC content: 70.54

Gene sequence:

>645_bases
GTGTTCCTCACCCGCAAGGCCCAGCTGGTCACCCCCGACCAGGCCCTTCCCGGCCGCAGCGAGCGCACCTTCGCGCTCCC
GGAGCGGCACCGCGTCCTGGACGCGCCGGTCTTCACCGAGGAGATCCCTGCGGGCTACGAGGTCGCGCTGTTCGGCCTGG
GCTGCTTCTGGGGCGCCGAGGAGATCTACTGGCAGGTCCCCGGCGTGTGGTCCACCTCGGTCGGCTACGCCGGCGGCACG
ACCCCGAACCCGTCGTACGAGGAGGTCTGCACCGGCGCGACCAACCACACCGAGGCCGTGCGGATCGTCTTCGACCCGGC
GCGGGTCTCCTTCGCCGACCTGGTCAAGACGTTCTTCGAGGTGCACGACCCGACCCAGGGCTTCCGCCAGGGCAACGACG
TCGGCACCCAGTACCGCTCCGCGATCTACTTCACCACCCCGGAGCAGGAGCGGGTCGCCCGCGAGCTCACCGAGGTGTAC
GGCGCGGAGCTGCGCCGCCGCCGCCTCGGGGACGTCACCACCGAGATCCGCGAGGCCCCGACGTACTACTACGCCGAGGA
CGTGCACCAGCAGTACCTCGCGAAGAACCCCAACGGCTACCGCTGCCACGCGAACACCGGGATCAAGTTCCCCGAGACCG
CCTGA

Upstream 100 bases:

>100_bases
ACCCGCGATGCCTACTGCGCGGAGCACGGCTGACCGGGAACGCCACGGACTCGGCCGGTGTTGGAGACTGTGGATCGTCA
CTCCGACAGAAGGAGAGCCC

Downstream 100 bases:

>100_bases
CCTGCAGCGACGGGCCCCGCCGCCGGCGCGGGCCACGCGCAGCCGCTCACGGGTACGCCGACCCGGTCACCCGCTCTCGG
AGGGGCCGAGCTCGCTGACC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MFLTRKAQLVTPDQALPGRSERTFALPERHRVLDAPVFTEEIPAGYEVALFGLGCFWGAEEIYWQVPGVWSTSVGYAGGT
TPNPSYEEVCTGATNHTEAVRIVFDPARVSFADLVKTFFEVHDPTQGFRQGNDVGTQYRSAIYFTTPEQERVARELTEVY
GAELRRRRLGDVTTEIREAPTYYYAEDVHQQYLAKNPNGYRCHANTGIKFPETA

Sequences:

>Translated_214_residues
MFLTRKAQLVTPDQALPGRSERTFALPERHRVLDAPVFTEEIPAGYEVALFGLGCFWGAEEIYWQVPGVWSTSVGYAGGT
TPNPSYEEVCTGATNHTEAVRIVFDPARVSFADLVKTFFEVHDPTQGFRQGNDVGTQYRSAIYFTTPEQERVARELTEVY
GAELRRRRLGDVTTEIREAPTYYYAEDVHQQYLAKNPNGYRCHANTGIKFPETA
>Mature_214_residues
MFLTRKAQLVTPDQALPGRSERTFALPERHRVLDAPVFTEEIPAGYEVALFGLGCFWGAEEIYWQVPGVWSTSVGYAGGT
TPNPSYEEVCTGATNHTEAVRIVFDPARVSFADLVKTFFEVHDPTQGFRQGNDVGTQYRSAIYFTTPEQERVARELTEVY
GAELRRRRLGDVTTEIREAPTYYYAEDVHQQYLAKNPNGYRCHANTGIKFPETA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=205, Percent_Identity=51.219512195122, Blast_Score=218, Evalue=3e-57,
Organism=Homo sapiens, GI208609995, Length=185, Percent_Identity=52.4324324324324, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI208609993, Length=205, Percent_Identity=39.0243902439024, Blast_Score=138, Evalue=3e-33,
Organism=Escherichia coli, GI1790665, Length=198, Percent_Identity=52.5252525252525, Blast_Score=204, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=37.6712328767123, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=168, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=34.3373493975904, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=34.9397590361446, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553131, Length=162, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24154; Mature: 24154

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLTRKAQLVTPDQALPGRSERTFALPERHRVLDAPVFTEEIPAGYEVALFGLGCFWGAE
CCCCCCCEEECCCCCCCCCCCCEEECCHHHHEECCCCCHHHCCCCCEEEEEEHHHHHCCC
EIYWQVPGVWSTSVGYAGGTTPNPSYEEVCTGATNHTEAVRIVFDPARVSFADLVKTFFE
CEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VHDPTQGFRQGNDVGTQYRSAIYFTTPEQERVARELTEVYGAELRRRRLGDVTTEIREAP
HCCCHHHHHCCCHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TYYYAEDVHQQYLAKNPNGYRCHANTGIKFPETA
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MFLTRKAQLVTPDQALPGRSERTFALPERHRVLDAPVFTEEIPAGYEVALFGLGCFWGAE
CCCCCCCEEECCCCCCCCCCCCEEECCHHHHEECCCCCHHHCCCCCEEEEEEHHHHHCCC
EIYWQVPGVWSTSVGYAGGTTPNPSYEEVCTGATNHTEAVRIVFDPARVSFADLVKTFFE
CEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VHDPTQGFRQGNDVGTQYRSAIYFTTPEQERVARELTEVYGAELRRRRLGDVTTEIREAP
HCCCHHHHHCCCHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TYYYAEDVHQQYLAKNPNGYRCHANTGIKFPETA
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA